Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS Study
While Major Depressive Disorder (MDD) is primarily characterized by mood disturbances, impaired attentional control is increasingly identified as a critical feature of depression. Deep transcranial magnetic stimulation (deepTMS), a noninvasive neuromodulatory technique, can modulate neural activity...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/5760141 |
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| author | Jodie Naim-Feil John L. Bradshaw Dianne M. Sheppard Oded Rosenberg Yechiel Levkovitz Pinhas Dannon Paul B. Fitzgerald Moshe Isserles Abraham Zangen |
| author_facet | Jodie Naim-Feil John L. Bradshaw Dianne M. Sheppard Oded Rosenberg Yechiel Levkovitz Pinhas Dannon Paul B. Fitzgerald Moshe Isserles Abraham Zangen |
| author_sort | Jodie Naim-Feil |
| collection | DOAJ |
| description | While Major Depressive Disorder (MDD) is primarily characterized by mood disturbances, impaired attentional control is increasingly identified as a critical feature of depression. Deep transcranial magnetic stimulation (deepTMS), a noninvasive neuromodulatory technique, can modulate neural activity and induce neuroplasticity changes in brain regions recruited by attentional processes. This study examined whether acute and long-term high-frequency repetitive deepTMS to the dorsolateral prefrontal cortex (DLPFC) can attenuate attentional deficits associated with MDD. Twenty-one MDD patients and 26 matched control subjects (CS) were administered the Beck Depression Inventory and the Sustained Attention to Response Task (SART) at baseline. MDD patients were readministered the SART and depressive assessments following a single session (n=21) and after 4 weeks (n=13) of high-frequency (20 Hz) repetitive deepTMS applied to the DLPFC. To control for the practice effect, CS (n=26) were readministered the SART a further two times. The MDD group exhibited deficits in sustained attention and cognitive inhibition. Both acute and long-term high-frequency repetitive frontal deepTMS ameliorated sustained attention deficits in the MDD group. Improvement after acute deepTMS was related to attentional recovery after long-term deepTMS. Longer-term improvement in sustained attention was not related to antidepressant effects of deepTMS treatment. |
| format | Article |
| id | doaj-art-36f4c27f4dcb48e38324e3edd0ca1ea4 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-36f4c27f4dcb48e38324e3edd0ca1ea42025-02-03T05:44:29ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/57601415760141Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS StudyJodie Naim-Feil0John L. Bradshaw1Dianne M. Sheppard2Oded Rosenberg3Yechiel Levkovitz4Pinhas Dannon5Paul B. Fitzgerald6Moshe Isserles7Abraham Zangen8Monash Alfred Psychiatry Research Centre, Central Clinical School, The Alfred and Monash University, Prahran, VIC, AustraliaSchool of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, VIC 3800, AustraliaMonash Injury Research Institute, Monash University, Clayton, VIC 3800, AustraliaBeer Yaakov Mental Health Center Affiliated to Sackler School of Medicine, University of Tel Aviv, IsraelThe Emotion-Cognition Research Center, Shalvata Mental Health Care Center, Hod HaSharon, IsraelBeer Yaakov Mental Health Center Affiliated to Sackler School of Medicine, University of Tel Aviv, IsraelMonash Alfred Psychiatry Research Centre, Central Clinical School, The Alfred and Monash University, Prahran, VIC, AustraliaHadassah-Hebrew University Medical Center, Jerusalem, IsraelDepartment of Life Sciences, Ben Gurion University, Beer Sheva 84105, IsraelWhile Major Depressive Disorder (MDD) is primarily characterized by mood disturbances, impaired attentional control is increasingly identified as a critical feature of depression. Deep transcranial magnetic stimulation (deepTMS), a noninvasive neuromodulatory technique, can modulate neural activity and induce neuroplasticity changes in brain regions recruited by attentional processes. This study examined whether acute and long-term high-frequency repetitive deepTMS to the dorsolateral prefrontal cortex (DLPFC) can attenuate attentional deficits associated with MDD. Twenty-one MDD patients and 26 matched control subjects (CS) were administered the Beck Depression Inventory and the Sustained Attention to Response Task (SART) at baseline. MDD patients were readministered the SART and depressive assessments following a single session (n=21) and after 4 weeks (n=13) of high-frequency (20 Hz) repetitive deepTMS applied to the DLPFC. To control for the practice effect, CS (n=26) were readministered the SART a further two times. The MDD group exhibited deficits in sustained attention and cognitive inhibition. Both acute and long-term high-frequency repetitive frontal deepTMS ameliorated sustained attention deficits in the MDD group. Improvement after acute deepTMS was related to attentional recovery after long-term deepTMS. Longer-term improvement in sustained attention was not related to antidepressant effects of deepTMS treatment.http://dx.doi.org/10.1155/2016/5760141 |
| spellingShingle | Jodie Naim-Feil John L. Bradshaw Dianne M. Sheppard Oded Rosenberg Yechiel Levkovitz Pinhas Dannon Paul B. Fitzgerald Moshe Isserles Abraham Zangen Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS Study Neural Plasticity |
| title | Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS Study |
| title_full | Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS Study |
| title_fullStr | Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS Study |
| title_full_unstemmed | Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS Study |
| title_short | Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS Study |
| title_sort | neuromodulation of attentional control in major depression a pilot deeptms study |
| url | http://dx.doi.org/10.1155/2016/5760141 |
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