Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients
Osteoporosis is the most common bone disorder, characterized by low bone mineral density and microarchitectural deterioration of the bone tissue, which increases the susceptibility to fracture. In the past decade, emerging research findings reported the implication of gut microbiota on bone health a...
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| Format: | Article |
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Tsinghua University Press
2024-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023001052 |
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| author | Pauline Duffuler Khushwant S. Bhullar Jianping Wu |
| author_facet | Pauline Duffuler Khushwant S. Bhullar Jianping Wu |
| author_sort | Pauline Duffuler |
| collection | DOAJ |
| description | Osteoporosis is the most common bone disorder, characterized by low bone mineral density and microarchitectural deterioration of the bone tissue, which increases the susceptibility to fracture. In the past decade, emerging research findings reported the implication of gut microbiota on bone health and osteoporosis pathology. Osteoporotic patients or individuals with a lower bone mineral density exhibit an alteration of the gut microbiota at several taxonomic levels. Additional reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function (mineral availability and absorption, gut integrity), the immune system, and the endocrine system. Thus, based on the vital role of gut microbiota on bone health, it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of osteoporosis. Microbial-based functional food ingredients, such as probiotics, prebiotics, synbiotics, and fermented foods, have been developed to alter the gut microbiota composition and function and thus, to provide benefits to the host bone health. Despite promising initial results, microbial-based therapies are still under investigation. Moreover, additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications. |
| format | Article |
| id | doaj-art-36f34fd9f6644e03b056d2acea204ddb |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-36f34fd9f6644e03b056d2acea204ddb2025-02-03T06:57:18ZengTsinghua University PressFood Science and Human Wellness2213-45302024-01-01131115Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredientsPauline Duffuler0Khushwant S. Bhullar1Jianping Wu2Department of Agricultural Food & Nutritional Science, University of Alberta, Edmonton T6G 2P5, CanadaDepartment of Agricultural Food & Nutritional Science, University of Alberta, Edmonton T6G 2P5, CanadaCorresponding author at: Department of Agricultural Food & Nutritional Science, University of Alberta, Edmonton T6G 2P5, Canada.; Department of Agricultural Food & Nutritional Science, University of Alberta, Edmonton T6G 2P5, CanadaOsteoporosis is the most common bone disorder, characterized by low bone mineral density and microarchitectural deterioration of the bone tissue, which increases the susceptibility to fracture. In the past decade, emerging research findings reported the implication of gut microbiota on bone health and osteoporosis pathology. Osteoporotic patients or individuals with a lower bone mineral density exhibit an alteration of the gut microbiota at several taxonomic levels. Additional reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function (mineral availability and absorption, gut integrity), the immune system, and the endocrine system. Thus, based on the vital role of gut microbiota on bone health, it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of osteoporosis. Microbial-based functional food ingredients, such as probiotics, prebiotics, synbiotics, and fermented foods, have been developed to alter the gut microbiota composition and function and thus, to provide benefits to the host bone health. Despite promising initial results, microbial-based therapies are still under investigation. Moreover, additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.http://www.sciencedirect.com/science/article/pii/S2213453023001052DysbiosisBone healthProbioticPrebioticFermented foodSynbiotic |
| spellingShingle | Pauline Duffuler Khushwant S. Bhullar Jianping Wu Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients Food Science and Human Wellness Dysbiosis Bone health Probiotic Prebiotic Fermented food Synbiotic |
| title | Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients |
| title_full | Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients |
| title_fullStr | Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients |
| title_full_unstemmed | Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients |
| title_short | Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients |
| title_sort | targeting gut microbiota in osteoporosis impact of the microbial based functional food ingredients |
| topic | Dysbiosis Bone health Probiotic Prebiotic Fermented food Synbiotic |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023001052 |
| work_keys_str_mv | AT paulineduffuler targetinggutmicrobiotainosteoporosisimpactofthemicrobialbasedfunctionalfoodingredients AT khushwantsbhullar targetinggutmicrobiotainosteoporosisimpactofthemicrobialbasedfunctionalfoodingredients AT jianpingwu targetinggutmicrobiotainosteoporosisimpactofthemicrobialbasedfunctionalfoodingredients |