Associations between dietary fatty acids and kidney stones
Abstract Kidney stones represent a significant global health challenge, with dietary habits playing a crucial role in their formation. This study investigates the association between dietary fatty acid intake—specifically saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA...
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Nature Portfolio
2025-01-01
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| author | Ning Tan Ya Zhang |
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| description | Abstract Kidney stones represent a significant global health challenge, with dietary habits playing a crucial role in their formation. This study investigates the association between dietary fatty acid intake—specifically saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA)—and the prevalence of kidney stones in a U.S. adult population, aiming to inform potential dietary prevention strategies. Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007–2018 were analyzed, including 30,716 participants. Logistic regression models were used to assess the relationship between fatty acid intake and kidney stones prevalence, adjusting for demographic and health-related covariates such as age, sex, BMI, diabetes status, physical activity, and other dietary factors. Additional analyses were conducted to explore the effects of fatty acid intake as a percentage of total energy and the impact of various fatty acid ratios. Higher intakes of SFA, MUFA, and PUFA were associated with increased odds of kidney stones prevalence. Specifically, each 10 g/day increase in SFA, MUFA, and PUFA intake was linked to a 22% [OR = 1.22, 95% CI: 1.11–1.34, p = 0.002], 10% [OR = 1.10, 95% CI: 1.00–1.22, p = 0.052] and 21% [OR = 1.21, 95% CI: 1.10–1.33, p = 0.001] higher odds of kidney stones, respectively. These associations were generally consistent across various subgroups. Additional analyses examining fatty acid intake as a percentage of total energy and various fatty acid ratios yielded compatible findings. The findings suggest a modest association between higher dietary fatty acid intake and increased odds of kidney stones prevalence. While the observed odds increases were relatively small, these results highlight the importance of considering dietary fatty acid types in kidney stones prevention strategies. Future research is needed to further elucidate the underlying mechanisms and to refine dietary recommendations. |
| format | Article |
| id | doaj-art-36f1c7c4e0c54ca7a6b5d8f2ede46028 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-36f1c7c4e0c54ca7a6b5d8f2ede460282025-01-26T12:25:44ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-86850-xAssociations between dietary fatty acids and kidney stonesNing Tan0Ya Zhang1Department of Urology, The Affiliated Second Hospital, Hengyang Medical school, University of South ChinaDepartment of Urology, The Affiliated Second Hospital, Hengyang Medical school, University of South ChinaAbstract Kidney stones represent a significant global health challenge, with dietary habits playing a crucial role in their formation. This study investigates the association between dietary fatty acid intake—specifically saturated (SFA), monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA)—and the prevalence of kidney stones in a U.S. adult population, aiming to inform potential dietary prevention strategies. Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007–2018 were analyzed, including 30,716 participants. Logistic regression models were used to assess the relationship between fatty acid intake and kidney stones prevalence, adjusting for demographic and health-related covariates such as age, sex, BMI, diabetes status, physical activity, and other dietary factors. Additional analyses were conducted to explore the effects of fatty acid intake as a percentage of total energy and the impact of various fatty acid ratios. Higher intakes of SFA, MUFA, and PUFA were associated with increased odds of kidney stones prevalence. Specifically, each 10 g/day increase in SFA, MUFA, and PUFA intake was linked to a 22% [OR = 1.22, 95% CI: 1.11–1.34, p = 0.002], 10% [OR = 1.10, 95% CI: 1.00–1.22, p = 0.052] and 21% [OR = 1.21, 95% CI: 1.10–1.33, p = 0.001] higher odds of kidney stones, respectively. These associations were generally consistent across various subgroups. Additional analyses examining fatty acid intake as a percentage of total energy and various fatty acid ratios yielded compatible findings. The findings suggest a modest association between higher dietary fatty acid intake and increased odds of kidney stones prevalence. While the observed odds increases were relatively small, these results highlight the importance of considering dietary fatty acid types in kidney stones prevention strategies. Future research is needed to further elucidate the underlying mechanisms and to refine dietary recommendations.https://doi.org/10.1038/s41598-025-86850-xKidney stonesNHANESDietary intakeFatty acid |
| spellingShingle | Ning Tan Ya Zhang Associations between dietary fatty acids and kidney stones Scientific Reports Kidney stones NHANES Dietary intake Fatty acid |
| title | Associations between dietary fatty acids and kidney stones |
| title_full | Associations between dietary fatty acids and kidney stones |
| title_fullStr | Associations between dietary fatty acids and kidney stones |
| title_full_unstemmed | Associations between dietary fatty acids and kidney stones |
| title_short | Associations between dietary fatty acids and kidney stones |
| title_sort | associations between dietary fatty acids and kidney stones |
| topic | Kidney stones NHANES Dietary intake Fatty acid |
| url | https://doi.org/10.1038/s41598-025-86850-x |
| work_keys_str_mv | AT ningtan associationsbetweendietaryfattyacidsandkidneystones AT yazhang associationsbetweendietaryfattyacidsandkidneystones |