Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus
Diabetes mellitus (DM) is a chronic metabolic disease, and its incidence is growing worldwide. The endoplasmic reticulum (ER) is a central component of cellular functions and is involved in protein folding and trafficking, lipid synthesis, and maintenance of calcium homeostasis. The ER is also a sen...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/193461 |
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| _version_ | 1832552152313102336 |
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| author | Jing Su Lei Zhou Xiaoxia Kong Xiaochun Yang Xiyan Xiang Yu Zhang Xiaoning Li Liankun Sun |
| author_facet | Jing Su Lei Zhou Xiaoxia Kong Xiaochun Yang Xiyan Xiang Yu Zhang Xiaoning Li Liankun Sun |
| author_sort | Jing Su |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a chronic metabolic disease, and its incidence is growing worldwide. The endoplasmic reticulum (ER) is a central component of cellular functions and is involved in protein folding and trafficking, lipid synthesis, and maintenance of calcium homeostasis. The ER is also a sensor of both intra- and extracellular stress and thus participates in monitoring and maintaining cellular homeostasis. Therefore, the ER is one site of interaction between environmental signals and a cell’s biological function. The ER is tightly linked to autophagy, inflammation, and apoptosis, and recent evidence suggests that these processes are related to the pathogenesis of DM and its complications. Thus, the ER has been considered an intersection integrating multiple stress responses and playing an important role in metabolism-related diseases including DM. Here, we review the relationship between the ER and autophagy, inflammation, and apoptosis in DM to better understand the molecular mechanisms of this disease. |
| format | Article |
| id | doaj-art-36e97a604b9c4f8fb3a62ce3826ea102 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-36e97a604b9c4f8fb3a62ce3826ea1022025-02-03T05:59:21ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/193461193461Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes MellitusJing Su0Lei Zhou1Xiaoxia Kong2Xiaochun Yang3Xiyan Xiang4Yu Zhang5Xiaoning Li6Liankun Sun7Department of Pathophysiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, ChinaDepartment of Pathology, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, ChinaInstitute of Hypoxia Research, School of Basic Medical Sciences, Wenzhou Medical College, Wenzhou, Zhejiang 325035, ChinaDepartment of Pathophysiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, ChinaDepartment of Pathophysiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, ChinaDepartment of Pathophysiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, ChinaDepartment of Pathophysiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, ChinaDepartment of Pathophysiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, ChinaDiabetes mellitus (DM) is a chronic metabolic disease, and its incidence is growing worldwide. The endoplasmic reticulum (ER) is a central component of cellular functions and is involved in protein folding and trafficking, lipid synthesis, and maintenance of calcium homeostasis. The ER is also a sensor of both intra- and extracellular stress and thus participates in monitoring and maintaining cellular homeostasis. Therefore, the ER is one site of interaction between environmental signals and a cell’s biological function. The ER is tightly linked to autophagy, inflammation, and apoptosis, and recent evidence suggests that these processes are related to the pathogenesis of DM and its complications. Thus, the ER has been considered an intersection integrating multiple stress responses and playing an important role in metabolism-related diseases including DM. Here, we review the relationship between the ER and autophagy, inflammation, and apoptosis in DM to better understand the molecular mechanisms of this disease.http://dx.doi.org/10.1155/2013/193461 |
| spellingShingle | Jing Su Lei Zhou Xiaoxia Kong Xiaochun Yang Xiyan Xiang Yu Zhang Xiaoning Li Liankun Sun Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus Journal of Diabetes Research |
| title | Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus |
| title_full | Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus |
| title_fullStr | Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus |
| title_full_unstemmed | Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus |
| title_short | Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus |
| title_sort | endoplasmic reticulum is at the crossroads of autophagy inflammation and apoptosis signaling pathways and participates in the pathogenesis of diabetes mellitus |
| url | http://dx.doi.org/10.1155/2013/193461 |
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