Training data diversity enhances the basecalling of novel RNA modification-induced nanopore sequencing readouts

Training data diversity enhances the basecalling of novel RNA modification-induced nanopore sequencing readouts

Abstract Accurately basecalling sequence backbones in the presence of nucleotide modifications remains a substantial challenge in nanopore sequencing bioinformatics. It has been extensively demonstrated that state-of-the-art basecallers are less compatible with modification-induced sequencing signal...

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Bibliographic Details
Main Authors: Ziyuan Wang, Ziyang Liu, Yinshan Fang, Hao Helen Zhang, Xiaoxiao Sun, Ning Hao, Jianwen Que, Hongxu Ding
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-55974-z
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