REDD1 mediates HDM-induced nuclear-cytoplasmic translocation and release of IL-33 in airway epithelial cells by downregulating Nrf2

REDD1 mediates HDM-induced nuclear-cytoplasmic translocation and release of IL-33 in airway epithelial cells by downregulating Nrf2

Abstract Objective This study aims to investigate whether REDD1 (Regulated in Development and DNA Damage Responses 1) mediates the nuclear-to-cytoplasmic translocation and release of IL-33 in airway epithelial cells induced by house dust mites (HDM). Methods REDD1 expression levels in bronchial asth...

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Bibliographic Details
Main Authors: Tian Luo, Wentao Ji, Yuxin Gong, Lichang Chen, Chao Liu, Dandan Zhang, Xi Li, Yanhua Lv
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Respiratory Research
Subjects:
REDD1
Nrf2
IL-33
Airway epithelium cells
Asthma
Online Access:https://doi.org/10.1186/s12931-025-03119-7
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