Altered olfactory responses in Fmr1 KO mice
Abstract Fragile X syndrome (FXS) is a neurodevelopmental disorder oftentimes associated with abnormal social behaviors and altered sensory responsiveness. It is hypothesized that the inappropriate filtering of sensory stimuli, including olfaction, can lead to aberrant social behavior in FXS. Howeve...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-80000-5 |
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| author | Jan Tuma Amtul-Noor Rana Teena Philip Jeong Ben Park Hye Young Lee |
| author_facet | Jan Tuma Amtul-Noor Rana Teena Philip Jeong Ben Park Hye Young Lee |
| author_sort | Jan Tuma |
| collection | DOAJ |
| description | Abstract Fragile X syndrome (FXS) is a neurodevelopmental disorder oftentimes associated with abnormal social behaviors and altered sensory responsiveness. It is hypothesized that the inappropriate filtering of sensory stimuli, including olfaction, can lead to aberrant social behavior in FXS. However, previous studies investigating olfaction in animal models of FXS have shown inconsistent results. Here, we found that Fmr1 knock-out (KO) mice, a mouse model of FXS, showed increased sniffing duration for non-social odors during their first exposure. Additionally, while wild-type (WT) males demonstrated differences in behavioral patterns between non-social odors while Fmr1 KO males did not show such distinction. We also showed that Fmr1 KO males spent significantly less time sniffing female urine odor compared to WT males. Moreover, we found an increased volume of the olfactory bulb in Fmr1 KO males. Overall, our findings suggest that the Fmr1 KO mice demonstrate atypical olfactory behaviors as well as structural changes in the olfactory bulb. |
| format | Article |
| id | doaj-art-36d45377828c4928a28d0f7d2fc9a4b1 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-36d45377828c4928a28d0f7d2fc9a4b12025-01-26T12:32:19ZengNature PortfolioScientific Reports2045-23222025-01-0115111610.1038/s41598-024-80000-5Altered olfactory responses in Fmr1 KO miceJan Tuma0Amtul-Noor Rana1Teena Philip2Jeong Ben Park3Hye Young Lee4The Department of Cellular and Integrative Physiology, The University of Texas Health Science Center at San AntonioThe Department of Cellular and Integrative Physiology, The University of Texas Health Science Center at San AntonioThe Department of Cellular and Integrative Physiology, The University of Texas Health Science Center at San AntonioThe Department of Cellular and Integrative Physiology, The University of Texas Health Science Center at San AntonioThe Department of Cellular and Integrative Physiology, The University of Texas Health Science Center at San AntonioAbstract Fragile X syndrome (FXS) is a neurodevelopmental disorder oftentimes associated with abnormal social behaviors and altered sensory responsiveness. It is hypothesized that the inappropriate filtering of sensory stimuli, including olfaction, can lead to aberrant social behavior in FXS. However, previous studies investigating olfaction in animal models of FXS have shown inconsistent results. Here, we found that Fmr1 knock-out (KO) mice, a mouse model of FXS, showed increased sniffing duration for non-social odors during their first exposure. Additionally, while wild-type (WT) males demonstrated differences in behavioral patterns between non-social odors while Fmr1 KO males did not show such distinction. We also showed that Fmr1 KO males spent significantly less time sniffing female urine odor compared to WT males. Moreover, we found an increased volume of the olfactory bulb in Fmr1 KO males. Overall, our findings suggest that the Fmr1 KO mice demonstrate atypical olfactory behaviors as well as structural changes in the olfactory bulb.https://doi.org/10.1038/s41598-024-80000-5Olfactory bulbOlfactory behaviorOdor discrimination testFragile X syndromeFmr1 KO mice |
| spellingShingle | Jan Tuma Amtul-Noor Rana Teena Philip Jeong Ben Park Hye Young Lee Altered olfactory responses in Fmr1 KO mice Scientific Reports Olfactory bulb Olfactory behavior Odor discrimination test Fragile X syndrome Fmr1 KO mice |
| title | Altered olfactory responses in Fmr1 KO mice |
| title_full | Altered olfactory responses in Fmr1 KO mice |
| title_fullStr | Altered olfactory responses in Fmr1 KO mice |
| title_full_unstemmed | Altered olfactory responses in Fmr1 KO mice |
| title_short | Altered olfactory responses in Fmr1 KO mice |
| title_sort | altered olfactory responses in fmr1 ko mice |
| topic | Olfactory bulb Olfactory behavior Odor discrimination test Fragile X syndrome Fmr1 KO mice |
| url | https://doi.org/10.1038/s41598-024-80000-5 |
| work_keys_str_mv | AT jantuma alteredolfactoryresponsesinfmr1komice AT amtulnoorrana alteredolfactoryresponsesinfmr1komice AT teenaphilip alteredolfactoryresponsesinfmr1komice AT jeongbenpark alteredolfactoryresponsesinfmr1komice AT hyeyounglee alteredolfactoryresponsesinfmr1komice |