A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related?
ABSTRACT Membranoproliferative glomerulonephritis (MPGN) has previously been used as an umbrella term to describe a spectrum of hypocomplementemic glomerular diseases, which are rare causes of end stage kidney disease (ESKD). We present a 22‐year‐old man with a well‐established medical history who h...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.70088 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589896788738048 |
|---|---|
| author | Ayman Azhary Mohammed Taha Nooh Mohamed Hajhamed Salahaldeen Ismail Mohammed Nouh Saad Mohamed Waleed Azhary Sir Alkhatim |
| author_facet | Ayman Azhary Mohammed Taha Nooh Mohamed Hajhamed Salahaldeen Ismail Mohammed Nouh Saad Mohamed Waleed Azhary Sir Alkhatim |
| author_sort | Ayman Azhary |
| collection | DOAJ |
| description | ABSTRACT Membranoproliferative glomerulonephritis (MPGN) has previously been used as an umbrella term to describe a spectrum of hypocomplementemic glomerular diseases, which are rare causes of end stage kidney disease (ESKD). We present a 22‐year‐old man with a well‐established medical history who had been complaining of 4 days of frothy dark urine, bilateral lower limb swelling, and puffiness on his face. For a month before his presentation, he had many bilateral skin lesions on his lower limbs that were leaking pus. Aside from the scars from the prior skin lesions, he had no other significant medical history, and his examination revealed no abnormalities. His tests revealed nephrotic range proteinuria with a normal renal profile, low serum albumin with low C3 and normal C4, and negative antinuclear antibodies (ANAs) by ELISA. After preliminary studies, we concluded that the condition was infection‐related glomerulonephritis. Nevertheless, following renal biopsy, which revealed an MPGN pattern, and immunohistochemistry, which revealed a full house picture, we conducted a second ANA test using the more sensitive/broader spectrum IFA hep2 cell test, which showed a coarse speckled nuclear pattern with a significant titer (1/1000), as well as a negative line blot assay test using 15 distinct antigens. Following the modification of our diagnosis to lupus nephritis, the patient responded fairly well once we started him on an immunosuppressive drug. The patient was released from the hospital in a stable condition. |
| format | Article |
| id | doaj-art-36cdcf4673174cd7b19ed251d49063fa |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-36cdcf4673174cd7b19ed251d49063fa2025-01-24T05:08:46ZengWileyClinical Case Reports2050-09042025-01-01131n/an/a10.1002/ccr3.70088A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related?Ayman Azhary0Mohammed Taha1Nooh Mohamed Hajhamed2Salahaldeen Ismail Mohammed3Nouh Saad Mohamed4Waleed Azhary Sir Alkhatim5Department of Medical Microbiology, Faculty of Medical Laboratory Sciences Omdurman Islamic University Khartoum SudanDepartment of Internal Medicine University of Gezira Gezira SudanDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences Omdurman Islamic University Khartoum SudanDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences Omdurman Islamic University Khartoum SudanMolecular Biology Unit Sirius Training and Research Centre Khartoum SudanDepartment of Internal Medicine University of Sinnar SudanABSTRACT Membranoproliferative glomerulonephritis (MPGN) has previously been used as an umbrella term to describe a spectrum of hypocomplementemic glomerular diseases, which are rare causes of end stage kidney disease (ESKD). We present a 22‐year‐old man with a well‐established medical history who had been complaining of 4 days of frothy dark urine, bilateral lower limb swelling, and puffiness on his face. For a month before his presentation, he had many bilateral skin lesions on his lower limbs that were leaking pus. Aside from the scars from the prior skin lesions, he had no other significant medical history, and his examination revealed no abnormalities. His tests revealed nephrotic range proteinuria with a normal renal profile, low serum albumin with low C3 and normal C4, and negative antinuclear antibodies (ANAs) by ELISA. After preliminary studies, we concluded that the condition was infection‐related glomerulonephritis. Nevertheless, following renal biopsy, which revealed an MPGN pattern, and immunohistochemistry, which revealed a full house picture, we conducted a second ANA test using the more sensitive/broader spectrum IFA hep2 cell test, which showed a coarse speckled nuclear pattern with a significant titer (1/1000), as well as a negative line blot assay test using 15 distinct antigens. Following the modification of our diagnosis to lupus nephritis, the patient responded fairly well once we started him on an immunosuppressive drug. The patient was released from the hospital in a stable condition.https://doi.org/10.1002/ccr3.70088antinuclear antibodies (ANAs)end stage kidney diseaselupus nephritismembranoproliferative glomerulonephritis |
| spellingShingle | Ayman Azhary Mohammed Taha Nooh Mohamed Hajhamed Salahaldeen Ismail Mohammed Nouh Saad Mohamed Waleed Azhary Sir Alkhatim A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related? Clinical Case Reports antinuclear antibodies (ANAs) end stage kidney disease lupus nephritis membranoproliferative glomerulonephritis |
| title | A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related? |
| title_full | A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related? |
| title_fullStr | A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related? |
| title_full_unstemmed | A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related? |
| title_short | A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related? |
| title_sort | case report of membranoproliferative glomerulonephritis infection related or immune related |
| topic | antinuclear antibodies (ANAs) end stage kidney disease lupus nephritis membranoproliferative glomerulonephritis |
| url | https://doi.org/10.1002/ccr3.70088 |
| work_keys_str_mv | AT aymanazhary acasereportofmembranoproliferativeglomerulonephritisinfectionrelatedorimmunerelated AT mohammedtaha acasereportofmembranoproliferativeglomerulonephritisinfectionrelatedorimmunerelated AT noohmohamedhajhamed acasereportofmembranoproliferativeglomerulonephritisinfectionrelatedorimmunerelated AT salahaldeenismailmohammed acasereportofmembranoproliferativeglomerulonephritisinfectionrelatedorimmunerelated AT nouhsaadmohamed acasereportofmembranoproliferativeglomerulonephritisinfectionrelatedorimmunerelated AT waleedazharysiralkhatim acasereportofmembranoproliferativeglomerulonephritisinfectionrelatedorimmunerelated AT aymanazhary casereportofmembranoproliferativeglomerulonephritisinfectionrelatedorimmunerelated AT mohammedtaha casereportofmembranoproliferativeglomerulonephritisinfectionrelatedorimmunerelated AT noohmohamedhajhamed casereportofmembranoproliferativeglomerulonephritisinfectionrelatedorimmunerelated AT salahaldeenismailmohammed casereportofmembranoproliferativeglomerulonephritisinfectionrelatedorimmunerelated AT nouhsaadmohamed casereportofmembranoproliferativeglomerulonephritisinfectionrelatedorimmunerelated AT waleedazharysiralkhatim casereportofmembranoproliferativeglomerulonephritisinfectionrelatedorimmunerelated |