A New Case of Granulomatosis with Polyangiitis Presented with Tolosa–Hunt Syndrome Manifestations
Background. Tolosa–Hunt syndrome (THS) is a rare disorder involving the orbital and retro-orbital space. The typical symptoms include sensory loss in the trigeminal nerve’s distribution, orbital pain, swelling, headaches, and cranial nerve palsies. Case Presentation. We report a 40-year-old female w...
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Wiley
2024-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2024/5552402 |
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| author | Maryam Mohebbi Shahriar Nafissi Majid Alikhani |
| author_facet | Maryam Mohebbi Shahriar Nafissi Majid Alikhani |
| author_sort | Maryam Mohebbi |
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| description | Background. Tolosa–Hunt syndrome (THS) is a rare disorder involving the orbital and retro-orbital space. The typical symptoms include sensory loss in the trigeminal nerve’s distribution, orbital pain, swelling, headaches, and cranial nerve palsies. Case Presentation. We report a 40-year-old female who initially presented with biparietal headache, unresponsive to medication, which then led to ophthalmoplegia and orbital pain. Serological findings demonstrated positive CANCA-PR3. She was initially treated with 1 g pulse methylprednisolone for three days. Based on the rheumatological evaluation and her positive lung nodule, hematuria, dysmorphic red blood cells, and positive antiproteinase 3 classic antineutrophil cytoplasm antibodies (CANCA-PR3) and also based on the diagnostic criteria for granulomatosis with polyangiitis criteria for Wegner disease, her treatment was continued with prednisolone 1 mg/kg and also rituximab at the first and 14th day of treatment. Conclusion. In our case of THS, we achieved satisfactory improvement in symptoms through the administration of high-dose steroids. |
| format | Article |
| id | doaj-art-36cb12ed25f54560b9b5cb44f232fd4f |
| institution | Kabale University |
| issn | 2090-6897 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-36cb12ed25f54560b9b5cb44f232fd4f2025-02-03T06:14:52ZengWileyCase Reports in Rheumatology2090-68972024-01-01202410.1155/2024/5552402A New Case of Granulomatosis with Polyangiitis Presented with Tolosa–Hunt Syndrome ManifestationsMaryam Mohebbi0Shahriar Nafissi1Majid Alikhani2Department of Internal MedicineDepartment of NeurologyDepartment of Internal MedicineBackground. Tolosa–Hunt syndrome (THS) is a rare disorder involving the orbital and retro-orbital space. The typical symptoms include sensory loss in the trigeminal nerve’s distribution, orbital pain, swelling, headaches, and cranial nerve palsies. Case Presentation. We report a 40-year-old female who initially presented with biparietal headache, unresponsive to medication, which then led to ophthalmoplegia and orbital pain. Serological findings demonstrated positive CANCA-PR3. She was initially treated with 1 g pulse methylprednisolone for three days. Based on the rheumatological evaluation and her positive lung nodule, hematuria, dysmorphic red blood cells, and positive antiproteinase 3 classic antineutrophil cytoplasm antibodies (CANCA-PR3) and also based on the diagnostic criteria for granulomatosis with polyangiitis criteria for Wegner disease, her treatment was continued with prednisolone 1 mg/kg and also rituximab at the first and 14th day of treatment. Conclusion. In our case of THS, we achieved satisfactory improvement in symptoms through the administration of high-dose steroids.http://dx.doi.org/10.1155/2024/5552402 |
| spellingShingle | Maryam Mohebbi Shahriar Nafissi Majid Alikhani A New Case of Granulomatosis with Polyangiitis Presented with Tolosa–Hunt Syndrome Manifestations Case Reports in Rheumatology |
| title | A New Case of Granulomatosis with Polyangiitis Presented with Tolosa–Hunt Syndrome Manifestations |
| title_full | A New Case of Granulomatosis with Polyangiitis Presented with Tolosa–Hunt Syndrome Manifestations |
| title_fullStr | A New Case of Granulomatosis with Polyangiitis Presented with Tolosa–Hunt Syndrome Manifestations |
| title_full_unstemmed | A New Case of Granulomatosis with Polyangiitis Presented with Tolosa–Hunt Syndrome Manifestations |
| title_short | A New Case of Granulomatosis with Polyangiitis Presented with Tolosa–Hunt Syndrome Manifestations |
| title_sort | new case of granulomatosis with polyangiitis presented with tolosa hunt syndrome manifestations |
| url | http://dx.doi.org/10.1155/2024/5552402 |
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