Metal-Free Synthesis of α-H Chlorine Alkylaromatic Hydrocarbons Driven by Visible Light
Chlorination is a widely used strategy at the industrial level. Chlorinated products represent indispensable building blocks in synthetic chemistry. Here, we report the synthesis of benzyl chlorides and α-chloro alkyl arenes, mediated by visible light, starting from variously substituted toluenes an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/2/312 |
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| author | Lidia De Luca Luca Ledda Andrea Porcheddu Massimo Carraro Luisa Pisano Silvia Gaspa |
| author_facet | Lidia De Luca Luca Ledda Andrea Porcheddu Massimo Carraro Luisa Pisano Silvia Gaspa |
| author_sort | Lidia De Luca |
| collection | DOAJ |
| description | Chlorination is a widely used strategy at the industrial level. Chlorinated products represent indispensable building blocks in synthetic chemistry. Here, we report the synthesis of benzyl chlorides and α-chloro alkyl arenes, mediated by visible light, starting from variously substituted toluenes and <i>N,N</i>-dichloroacetamide as a chlorinating reagent. This methodology is a valid alternative to the syntheses previously reported in the literature. It is a metal-free process and does not involve the use of additives or radical initiators. |
| format | Article |
| id | doaj-art-36c8f6581fae495a8042b80535aae072 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-36c8f6581fae495a8042b80535aae0722025-01-24T13:43:33ZengMDPI AGMolecules1420-30492025-01-0130231210.3390/molecules30020312Metal-Free Synthesis of α-H Chlorine Alkylaromatic Hydrocarbons Driven by Visible LightLidia De Luca0Luca Ledda1Andrea Porcheddu2Massimo Carraro3Luisa Pisano4Silvia Gaspa5Dipartimento di Scienze Chimiche, Fisiche, Matematiche e Naturali, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, ItalyDipartimento di Scienze Chimiche, Fisiche, Matematiche e Naturali, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, ItalyDipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Cittadella Universitaria, 09042 Monserrato, ItalyDipartimento di Scienze Chimiche, Fisiche, Matematiche e Naturali, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, ItalyDipartimento di Scienze Chimiche, Fisiche, Matematiche e Naturali, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, ItalyDipartimento di Scienze Chimiche, Fisiche, Matematiche e Naturali, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, ItalyChlorination is a widely used strategy at the industrial level. Chlorinated products represent indispensable building blocks in synthetic chemistry. Here, we report the synthesis of benzyl chlorides and α-chloro alkyl arenes, mediated by visible light, starting from variously substituted toluenes and <i>N,N</i>-dichloroacetamide as a chlorinating reagent. This methodology is a valid alternative to the syntheses previously reported in the literature. It is a metal-free process and does not involve the use of additives or radical initiators.https://www.mdpi.com/1420-3049/30/2/312benzyl chloridevisible lighttoluene |
| spellingShingle | Lidia De Luca Luca Ledda Andrea Porcheddu Massimo Carraro Luisa Pisano Silvia Gaspa Metal-Free Synthesis of α-H Chlorine Alkylaromatic Hydrocarbons Driven by Visible Light Molecules benzyl chloride visible light toluene |
| title | Metal-Free Synthesis of α-H Chlorine Alkylaromatic Hydrocarbons Driven by Visible Light |
| title_full | Metal-Free Synthesis of α-H Chlorine Alkylaromatic Hydrocarbons Driven by Visible Light |
| title_fullStr | Metal-Free Synthesis of α-H Chlorine Alkylaromatic Hydrocarbons Driven by Visible Light |
| title_full_unstemmed | Metal-Free Synthesis of α-H Chlorine Alkylaromatic Hydrocarbons Driven by Visible Light |
| title_short | Metal-Free Synthesis of α-H Chlorine Alkylaromatic Hydrocarbons Driven by Visible Light |
| title_sort | metal free synthesis of α h chlorine alkylaromatic hydrocarbons driven by visible light |
| topic | benzyl chloride visible light toluene |
| url | https://www.mdpi.com/1420-3049/30/2/312 |
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