Metal-Free Synthesis of α-H Chlorine Alkylaromatic Hydrocarbons Driven by Visible Light
Chlorination is a widely used strategy at the industrial level. Chlorinated products represent indispensable building blocks in synthetic chemistry. Here, we report the synthesis of benzyl chlorides and α-chloro alkyl arenes, mediated by visible light, starting from variously substituted toluenes an...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/2/312 |
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| Summary: | Chlorination is a widely used strategy at the industrial level. Chlorinated products represent indispensable building blocks in synthetic chemistry. Here, we report the synthesis of benzyl chlorides and α-chloro alkyl arenes, mediated by visible light, starting from variously substituted toluenes and <i>N,N</i>-dichloroacetamide as a chlorinating reagent. This methodology is a valid alternative to the syntheses previously reported in the literature. It is a metal-free process and does not involve the use of additives or radical initiators. |
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| ISSN: | 1420-3049 |