Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections
Azithromycin (AZT) encapsulated into various types of liposomes (AZT-liposomes) displayed pronounced in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA) (1). The present study represents a follow-up to this previous work, attempting to further explore the anti-MRSA potential...
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Sciendo
2023-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2023-0042 |
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| author | Rukavina Zora Jøraholmen May Wenche Božić Dunja Frankol Ivana Gašparović Petra Golja Škalko-Basnet Nataša Klarić Maja Šegvić Vanić Željka |
| author_facet | Rukavina Zora Jøraholmen May Wenche Božić Dunja Frankol Ivana Gašparović Petra Golja Škalko-Basnet Nataša Klarić Maja Šegvić Vanić Željka |
| author_sort | Rukavina Zora |
| collection | DOAJ |
| description | Azithromycin (AZT) encapsulated into various types of liposomes (AZT-liposomes) displayed pronounced in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA) (1). The present study represents a follow-up to this previous work, attempting to further explore the anti-MRSA potential of AZT-liposomes when incorporated into chitosan hydrogel (CHG). Incorporation of AZT-liposomes into CHG (liposomal CHGs) was intended to ensure proper viscosity and texture properties of the formulation, modification of antibiotic release, and enhanced antibacterial activity, aiming to upgrade the therapeutical potential of AZT-liposomes in localized treatment of MRSA-related skin infections. Four different liposomal CHGs were evaluated and compared on the grounds of antibacterial activity against MRSA, AZT release profiles, cytotoxicity, as well as texture, and rheological properties. To our knowledge, this study is the first to investigate the potential of liposomal CHGs for the topical localized treatment of MRSA-related skin infections. CHG ensured proper viscoelastic and texture properties to achieve prolonged retention and prolonged release of AZT at the application site, which resulted in a boosted anti-MRSA effect of the entrapped AZT-liposomes. With respect to anti-MRSA activity and biocompatibility, formulation CATL-CHG (cationic liposomes in CHG) is considered to be the most promising formulation for the treatment of MRSA-related skin infections. |
| format | Article |
| id | doaj-art-36c3bf79733143ae83aeb49d278172c4 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-36c3bf79733143ae83aeb49d278172c42025-02-03T10:25:27ZengSciendoActa Pharmaceutica1846-95582023-12-0173455957910.2478/acph-2023-0042Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infectionsRukavina Zora0Jøraholmen May Wenche1Božić Dunja2Frankol Ivana3Gašparović Petra Golja4Škalko-Basnet Nataša5Klarić Maja Šegvić6Vanić Željka71Department of Pharmaceutical Technology, University of Zagreb Faculty of Pharmacy and Biochemistry, 10000Zagreb, Croatia2Drug Transport and Delivery Research Group, Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 9037TromsøNorway3R&D, PLIVA Croatia Ltd. 10000Zagreb, Croatia1Department of Pharmaceutical Technology, University of Zagreb Faculty of Pharmacy and Biochemistry, 10000Zagreb, Croatia3R&D, PLIVA Croatia Ltd. 10000Zagreb, Croatia2Drug Transport and Delivery Research Group, Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 9037TromsøNorway4Department of Microbiology, University of Zagreb Faculty of Pharmacy and Biochemistry10000Zagreb, Croatia1Department of Pharmaceutical Technology, University of Zagreb Faculty of Pharmacy and Biochemistry, 10000Zagreb, CroatiaAzithromycin (AZT) encapsulated into various types of liposomes (AZT-liposomes) displayed pronounced in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA) (1). The present study represents a follow-up to this previous work, attempting to further explore the anti-MRSA potential of AZT-liposomes when incorporated into chitosan hydrogel (CHG). Incorporation of AZT-liposomes into CHG (liposomal CHGs) was intended to ensure proper viscosity and texture properties of the formulation, modification of antibiotic release, and enhanced antibacterial activity, aiming to upgrade the therapeutical potential of AZT-liposomes in localized treatment of MRSA-related skin infections. Four different liposomal CHGs were evaluated and compared on the grounds of antibacterial activity against MRSA, AZT release profiles, cytotoxicity, as well as texture, and rheological properties. To our knowledge, this study is the first to investigate the potential of liposomal CHGs for the topical localized treatment of MRSA-related skin infections. CHG ensured proper viscoelastic and texture properties to achieve prolonged retention and prolonged release of AZT at the application site, which resulted in a boosted anti-MRSA effect of the entrapped AZT-liposomes. With respect to anti-MRSA activity and biocompatibility, formulation CATL-CHG (cationic liposomes in CHG) is considered to be the most promising formulation for the treatment of MRSA-related skin infections.https://doi.org/10.2478/acph-2023-0042mrsaliposomal hydrogelazithromycinchitosantopical antimicrobial therapyskin infections |
| spellingShingle | Rukavina Zora Jøraholmen May Wenche Božić Dunja Frankol Ivana Gašparović Petra Golja Škalko-Basnet Nataša Klarić Maja Šegvić Vanić Željka Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections Acta Pharmaceutica mrsa liposomal hydrogel azithromycin chitosan topical antimicrobial therapy skin infections |
| title | Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections |
| title_full | Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections |
| title_fullStr | Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections |
| title_full_unstemmed | Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections |
| title_short | Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections |
| title_sort | azithromycin loaded liposomal hydrogel a step forward for enhanced treatment of mrsa related skin infections |
| topic | mrsa liposomal hydrogel azithromycin chitosan topical antimicrobial therapy skin infections |
| url | https://doi.org/10.2478/acph-2023-0042 |
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