Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats
Objectives. Aluminium, a neurotoxic agent in humans, has been implicated in the pathogenesis of neurodegenerative disorders. In this study, we examined the behavioral and biochemical effects of aluminium in rats with special emphasis on memory centres, namely, hippocampus and frontal cortex. Further...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2015/210169 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560098816294912 |
|---|---|
| author | Madhavan Nampoothiri Jessy John Nitesh Kumar Jayesh Mudgal Gopalan Kutty Nampurath Mallikarjuna Rao Chamallamudi |
| author_facet | Madhavan Nampoothiri Jessy John Nitesh Kumar Jayesh Mudgal Gopalan Kutty Nampurath Mallikarjuna Rao Chamallamudi |
| author_sort | Madhavan Nampoothiri |
| collection | DOAJ |
| description | Objectives. Aluminium, a neurotoxic agent in humans, has been implicated in the pathogenesis of neurodegenerative disorders. In this study, we examined the behavioral and biochemical effects of aluminium in rats with special emphasis on memory centres, namely, hippocampus and frontal cortex. Further, the effect of simvastatin treatment on aluminium intoxication was evaluated. Methods. Rats were exposed to aluminium chloride (AlCl3) for 60 days. Simvastatin (10 mg/kg/p.o.) and rivastigmine (1 mg/kg/p.o.) were administered daily prior to AlCl3. Behavioral parameters were assessed using Morris water maze test and actophotometer followed by biochemical investigations, namely, acetylcholinesterase (AChE) activity, TNF-α level, antioxidant enzymes (GSH, catalase), lipid peroxidation, and nitrite level in hippocampus and frontal cortex. Triglycerides, total cholesterol, LDL, and HDL levels in serum were also determined. Key Findings. Simvastatin treatment improved cognitive function and locomotor activity in rats. Simvastatin reversed hyperlipidemia and significantly rectified the deleterious effect of AlCl3 on AChE activity. Further, in hippocampus and frontal cortex, aluminium-induced elevation in nitrite and TNF-α and reduction in antioxidant enzymes were inhibited by simvastatin. Conclusion. To conclude, the present study suggests that simvastatin per se protects the neurons in hippocampus and frontal cortex from AlCl3, an environmental toxin. |
| format | Article |
| id | doaj-art-36aa7775f37e4ba08bb26e0d50326c86 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-36aa7775f37e4ba08bb26e0d50326c862025-02-03T01:28:24ZengWileyBehavioural Neurology0953-41801875-85842015-01-01201510.1155/2015/210169210169Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in RatsMadhavan Nampoothiri0Jessy John1Nitesh Kumar2Jayesh Mudgal3Gopalan Kutty Nampurath4Mallikarjuna Rao Chamallamudi5Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaDepartment of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, IndiaObjectives. Aluminium, a neurotoxic agent in humans, has been implicated in the pathogenesis of neurodegenerative disorders. In this study, we examined the behavioral and biochemical effects of aluminium in rats with special emphasis on memory centres, namely, hippocampus and frontal cortex. Further, the effect of simvastatin treatment on aluminium intoxication was evaluated. Methods. Rats were exposed to aluminium chloride (AlCl3) for 60 days. Simvastatin (10 mg/kg/p.o.) and rivastigmine (1 mg/kg/p.o.) were administered daily prior to AlCl3. Behavioral parameters were assessed using Morris water maze test and actophotometer followed by biochemical investigations, namely, acetylcholinesterase (AChE) activity, TNF-α level, antioxidant enzymes (GSH, catalase), lipid peroxidation, and nitrite level in hippocampus and frontal cortex. Triglycerides, total cholesterol, LDL, and HDL levels in serum were also determined. Key Findings. Simvastatin treatment improved cognitive function and locomotor activity in rats. Simvastatin reversed hyperlipidemia and significantly rectified the deleterious effect of AlCl3 on AChE activity. Further, in hippocampus and frontal cortex, aluminium-induced elevation in nitrite and TNF-α and reduction in antioxidant enzymes were inhibited by simvastatin. Conclusion. To conclude, the present study suggests that simvastatin per se protects the neurons in hippocampus and frontal cortex from AlCl3, an environmental toxin.http://dx.doi.org/10.1155/2015/210169 |
| spellingShingle | Madhavan Nampoothiri Jessy John Nitesh Kumar Jayesh Mudgal Gopalan Kutty Nampurath Mallikarjuna Rao Chamallamudi Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats Behavioural Neurology |
| title | Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats |
| title_full | Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats |
| title_fullStr | Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats |
| title_full_unstemmed | Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats |
| title_short | Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats |
| title_sort | modulatory role of simvastatin against aluminium chloride induced behavioural and biochemical changes in rats |
| url | http://dx.doi.org/10.1155/2015/210169 |
| work_keys_str_mv | AT madhavannampoothiri modulatoryroleofsimvastatinagainstaluminiumchlorideinducedbehaviouralandbiochemicalchangesinrats AT jessyjohn modulatoryroleofsimvastatinagainstaluminiumchlorideinducedbehaviouralandbiochemicalchangesinrats AT niteshkumar modulatoryroleofsimvastatinagainstaluminiumchlorideinducedbehaviouralandbiochemicalchangesinrats AT jayeshmudgal modulatoryroleofsimvastatinagainstaluminiumchlorideinducedbehaviouralandbiochemicalchangesinrats AT gopalankuttynampurath modulatoryroleofsimvastatinagainstaluminiumchlorideinducedbehaviouralandbiochemicalchangesinrats AT mallikarjunaraochamallamudi modulatoryroleofsimvastatinagainstaluminiumchlorideinducedbehaviouralandbiochemicalchangesinrats |