Synergistic activity of fosfomycin–meropenem and fosfomycin–colistin against carbapenem resistant Klebsiella pneumoniae: an in vitro evidence
Aim: To evaluate the antibacterial activity of fosfomycin–meropenem and fosfomycin–colistin combinations against carbapenem-resistant Klebsiella pneumoniae (CR-Kp). Methods: A total of 50 CR-Kp isolates recovered from blood cultures were included in this study. All the CR-Kp isolates were screened f...
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Taylor & Francis Group
2020-04-01
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| Series: | Future Science OA |
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| Online Access: | https://www.future-science.com/doi/10.2144/fsoa-2019-0074 |
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| author | Yamuna Devi Bakthavatchalam Abirami Shankar Dhiviya Prabaa Muthuirulandi Sethuvel Kalaiarasi Asokan Kalaiarasi Kanthan Balaji Veeraraghavan |
| author_facet | Yamuna Devi Bakthavatchalam Abirami Shankar Dhiviya Prabaa Muthuirulandi Sethuvel Kalaiarasi Asokan Kalaiarasi Kanthan Balaji Veeraraghavan |
| author_sort | Yamuna Devi Bakthavatchalam |
| collection | DOAJ |
| description | Aim: To evaluate the antibacterial activity of fosfomycin–meropenem and fosfomycin–colistin combinations against carbapenem-resistant Klebsiella pneumoniae (CR-Kp). Methods: A total of 50 CR-Kp isolates recovered from blood cultures were included in this study. All the CR-Kp isolates were screened for the presence of carbapenem resistant genes blaIMP. blaVIM. blaNDM. blaOXA-48 like, blaKPC. blaGES.#x00A0;and blaSPM. Combination testing of fosfomycin–meropenem and fosfomycin–colistin were performed using time-kill assay. Results: Fosfomycin–meropenem combination showed synergy in 20% of the tested CR-Kp isolates. While, fosfomycin–colistin exhibited synergy against 16% of the isolates. A total of 68% (n = 34) of CR-Kp isolates were characterised as OXA-48-like producers and 22% (n = 11) as NDM producers. Synergistic activity of these combinations was observed against OXA-48, NDM and NDM + OXA-48 co-producers. Conclusion: Considerable synergistic antibacterial activity of fosfomycin–meropenem and fosfomycin–colistin was not observed against CR-Kp isolates. Therefore, these combinations may not be promising for infections associated with CR-Kp. |
| format | Article |
| id | doaj-art-36a7e5de1b0e4e6190f753b8894e0ca7 |
| institution | OA Journals |
| issn | 2056-5623 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-36a7e5de1b0e4e6190f753b8894e0ca72025-08-20T02:25:48ZengTaylor & Francis GroupFuture Science OA2056-56232020-04-016410.2144/fsoa-2019-0074Synergistic activity of fosfomycin–meropenem and fosfomycin–colistin against carbapenem resistant Klebsiella pneumoniae: an in vitro evidenceYamuna Devi Bakthavatchalam0Abirami Shankar1Dhiviya Prabaa Muthuirulandi Sethuvel2Kalaiarasi Asokan3Kalaiarasi Kanthan4Balaji Veeraraghavan51Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India1Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India1Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India1Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India1Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India1Department of Clinical Microbiology, Christian Medical College, Vellore 632004, IndiaAim: To evaluate the antibacterial activity of fosfomycin–meropenem and fosfomycin–colistin combinations against carbapenem-resistant Klebsiella pneumoniae (CR-Kp). Methods: A total of 50 CR-Kp isolates recovered from blood cultures were included in this study. All the CR-Kp isolates were screened for the presence of carbapenem resistant genes blaIMP. blaVIM. blaNDM. blaOXA-48 like, blaKPC. blaGES.#x00A0;and blaSPM. Combination testing of fosfomycin–meropenem and fosfomycin–colistin were performed using time-kill assay. Results: Fosfomycin–meropenem combination showed synergy in 20% of the tested CR-Kp isolates. While, fosfomycin–colistin exhibited synergy against 16% of the isolates. A total of 68% (n = 34) of CR-Kp isolates were characterised as OXA-48-like producers and 22% (n = 11) as NDM producers. Synergistic activity of these combinations was observed against OXA-48, NDM and NDM + OXA-48 co-producers. Conclusion: Considerable synergistic antibacterial activity of fosfomycin–meropenem and fosfomycin–colistin was not observed against CR-Kp isolates. Therefore, these combinations may not be promising for infections associated with CR-Kp.https://www.future-science.com/doi/10.2144/fsoa-2019-0074colistinfosfomcyinfosfomycin–colistinfosfomycin–meropenemKlebsiella pneumoniaemeropenem |
| spellingShingle | Yamuna Devi Bakthavatchalam Abirami Shankar Dhiviya Prabaa Muthuirulandi Sethuvel Kalaiarasi Asokan Kalaiarasi Kanthan Balaji Veeraraghavan Synergistic activity of fosfomycin–meropenem and fosfomycin–colistin against carbapenem resistant Klebsiella pneumoniae: an in vitro evidence Future Science OA colistin fosfomcyin fosfomycin–colistin fosfomycin–meropenem Klebsiella pneumoniae meropenem |
| title | Synergistic activity of fosfomycin–meropenem and fosfomycin–colistin against carbapenem resistant Klebsiella pneumoniae: an in vitro evidence |
| title_full | Synergistic activity of fosfomycin–meropenem and fosfomycin–colistin against carbapenem resistant Klebsiella pneumoniae: an in vitro evidence |
| title_fullStr | Synergistic activity of fosfomycin–meropenem and fosfomycin–colistin against carbapenem resistant Klebsiella pneumoniae: an in vitro evidence |
| title_full_unstemmed | Synergistic activity of fosfomycin–meropenem and fosfomycin–colistin against carbapenem resistant Klebsiella pneumoniae: an in vitro evidence |
| title_short | Synergistic activity of fosfomycin–meropenem and fosfomycin–colistin against carbapenem resistant Klebsiella pneumoniae: an in vitro evidence |
| title_sort | synergistic activity of fosfomycin meropenem and fosfomycin colistin against carbapenem resistant klebsiella pneumoniae an in vitro evidence |
| topic | colistin fosfomcyin fosfomycin–colistin fosfomycin–meropenem Klebsiella pneumoniae meropenem |
| url | https://www.future-science.com/doi/10.2144/fsoa-2019-0074 |
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