Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
A number of advances have been made in the development of modified oligodeoxynucleotides (ODNs), and chemical or physical properties of which are controlled by external stimuli. These intelligent ODNs are promising for the next generation of gene diagnostics and therapy. This paper focuses on the mo...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2011/816207 |
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| _version_ | 1832548532421132288 |
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| author | Kazuhito Tanabe Takeo Ito Sei-ichi Nishimoto |
| author_facet | Kazuhito Tanabe Takeo Ito Sei-ichi Nishimoto |
| author_sort | Kazuhito Tanabe |
| collection | DOAJ |
| description | A number of advances have been made in the development of modified oligodeoxynucleotides (ODNs), and chemical or physical properties of which are controlled by external stimuli. These intelligent ODNs are promising for the next generation of gene diagnostics and therapy. This paper focuses on the molecular design of artificial ODNs that are activated by X-irradiation and their applications to regulation of hybridization properties, conformation change, radiation-activated DNAzyme, and decoy molecules. |
| format | Article |
| id | doaj-art-369c2ae8bfbe4aacad9da89a794e1de1 |
| institution | Kabale University |
| issn | 2090-021X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-369c2ae8bfbe4aacad9da89a794e1de12025-02-03T06:13:47ZengWileyJournal of Nucleic Acids2090-021X2011-01-01201110.4061/2011/816207816207Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide BondsKazuhito Tanabe0Takeo Ito1Sei-ichi Nishimoto2Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, JapanDepartment of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, JapanDepartment of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, JapanA number of advances have been made in the development of modified oligodeoxynucleotides (ODNs), and chemical or physical properties of which are controlled by external stimuli. These intelligent ODNs are promising for the next generation of gene diagnostics and therapy. This paper focuses on the molecular design of artificial ODNs that are activated by X-irradiation and their applications to regulation of hybridization properties, conformation change, radiation-activated DNAzyme, and decoy molecules.http://dx.doi.org/10.4061/2011/816207 |
| spellingShingle | Kazuhito Tanabe Takeo Ito Sei-ichi Nishimoto Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds Journal of Nucleic Acids |
| title | Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds |
| title_full | Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds |
| title_fullStr | Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds |
| title_full_unstemmed | Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds |
| title_short | Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds |
| title_sort | radiolytic reduction characteristics of artificial oligodeoxynucleotides possessing 2 oxoalkyl group or disulfide bonds |
| url | http://dx.doi.org/10.4061/2011/816207 |
| work_keys_str_mv | AT kazuhitotanabe radiolyticreductioncharacteristicsofartificialoligodeoxynucleotidespossessing2oxoalkylgroupordisulfidebonds AT takeoito radiolyticreductioncharacteristicsofartificialoligodeoxynucleotidespossessing2oxoalkylgroupordisulfidebonds AT seiichinishimoto radiolyticreductioncharacteristicsofartificialoligodeoxynucleotidespossessing2oxoalkylgroupordisulfidebonds |