Development of Cerebral Metastasis after Medical and Surgical Treatment of Anal Squamous Cell Carcinoma
Squamous cell carcinoma of the anus is a relatively uncommon GI malignancy. When it does occur, it metastasizes in only a small minority of patients. Spread of anal squamous cell carcinoma to the brain is exceedingly rare, and has been previously reported only three times in the medical literature....
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/912178 |
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| author | Andrew Austin Gassman Emil Fernando Casey Jacob Holmes Umesh Kapur Joshua M. Eberhardt |
| author_facet | Andrew Austin Gassman Emil Fernando Casey Jacob Holmes Umesh Kapur Joshua M. Eberhardt |
| author_sort | Andrew Austin Gassman |
| collection | DOAJ |
| description | Squamous cell carcinoma of the anus is a relatively uncommon GI malignancy. When it does occur, it metastasizes in only a small minority of patients. Spread of anal squamous cell carcinoma to the brain is exceedingly rare, and has been previously reported only three times in the medical literature. We report the case of a 67 year old male who was diagnosed on presentation with a poorly differentiated anal squamous cell carcinoma that already had a solitary metastasis to the liver. While the tumors were initially responsive to chemoradiotherapy, the patient’s primary and liver lesions recurred. The patient then underwent synchronous abdominoperineal resection for the primary lesion and a liver lobectomy for the metastasis. Soon thereafter, the patient developed focal neurologic symptoms and was found to have an intracranial lesion that on biopsy demonstrated metastatic squamous cell carcinoma. This case highlights the fact that patients with a previous history of anal squamous cell carcinoma can occasionally develop cerebral metastasis. Furthermore, cerebral metastases from anal squamous cell carcinoma portend a dismal prognosis even in the face of aggressive medical and surgical therapy. |
| format | Article |
| id | doaj-art-3686065e3c8d4033b18f8bb7f15cc083 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-3686065e3c8d4033b18f8bb7f15cc0832025-02-03T01:04:56ZengWileyCase Reports in Oncological Medicine2090-67062090-67142012-01-01201210.1155/2012/912178912178Development of Cerebral Metastasis after Medical and Surgical Treatment of Anal Squamous Cell CarcinomaAndrew Austin Gassman0Emil Fernando1Casey Jacob Holmes2Umesh Kapur3Joshua M. Eberhardt4Division of Colorectal Surgery, Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, USAStritch School of Medicine, Loyola University Medical Center, Maywood, IL 60153, USADivision of Colorectal Surgery, Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, USADepartment of Pathology, Loyola University Medical Center, Maywood, IL 60153, USADivision of Colorectal Surgery, Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, USASquamous cell carcinoma of the anus is a relatively uncommon GI malignancy. When it does occur, it metastasizes in only a small minority of patients. Spread of anal squamous cell carcinoma to the brain is exceedingly rare, and has been previously reported only three times in the medical literature. We report the case of a 67 year old male who was diagnosed on presentation with a poorly differentiated anal squamous cell carcinoma that already had a solitary metastasis to the liver. While the tumors were initially responsive to chemoradiotherapy, the patient’s primary and liver lesions recurred. The patient then underwent synchronous abdominoperineal resection for the primary lesion and a liver lobectomy for the metastasis. Soon thereafter, the patient developed focal neurologic symptoms and was found to have an intracranial lesion that on biopsy demonstrated metastatic squamous cell carcinoma. This case highlights the fact that patients with a previous history of anal squamous cell carcinoma can occasionally develop cerebral metastasis. Furthermore, cerebral metastases from anal squamous cell carcinoma portend a dismal prognosis even in the face of aggressive medical and surgical therapy.http://dx.doi.org/10.1155/2012/912178 |
| spellingShingle | Andrew Austin Gassman Emil Fernando Casey Jacob Holmes Umesh Kapur Joshua M. Eberhardt Development of Cerebral Metastasis after Medical and Surgical Treatment of Anal Squamous Cell Carcinoma Case Reports in Oncological Medicine |
| title | Development of Cerebral Metastasis after Medical and Surgical Treatment of Anal Squamous Cell Carcinoma |
| title_full | Development of Cerebral Metastasis after Medical and Surgical Treatment of Anal Squamous Cell Carcinoma |
| title_fullStr | Development of Cerebral Metastasis after Medical and Surgical Treatment of Anal Squamous Cell Carcinoma |
| title_full_unstemmed | Development of Cerebral Metastasis after Medical and Surgical Treatment of Anal Squamous Cell Carcinoma |
| title_short | Development of Cerebral Metastasis after Medical and Surgical Treatment of Anal Squamous Cell Carcinoma |
| title_sort | development of cerebral metastasis after medical and surgical treatment of anal squamous cell carcinoma |
| url | http://dx.doi.org/10.1155/2012/912178 |
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