Feasibility of Imaging Myelin Lesions in Multiple Sclerosis
The goal of this study was to provide a feasibility assessment for PET imaging of multiple sclerosis (MS) lesions based on their decreased myelin content relative to the surrounding normal-appearing brain tissue. The imaging agent evaluated for this purpose is a molecule that binds strongly and spec...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2011/953806 |
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| _version_ | 1832552150945759232 |
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| author | Maria I. Zavodszky John F. Graf Cristina A. Tan Hehir |
| author_facet | Maria I. Zavodszky John F. Graf Cristina A. Tan Hehir |
| author_sort | Maria I. Zavodszky |
| collection | DOAJ |
| description | The goal of this study was to provide a feasibility assessment for PET imaging of multiple sclerosis (MS) lesions based on their decreased myelin content relative to the surrounding normal-appearing brain tissue. The imaging agent evaluated for this purpose is a molecule that binds strongly and specifically to myelin basic protein. Physiology-based pharmacokinetic modeling combined with PET image simulation applied to a brain model was used to examine whether such an agent would allow the differentiation of artificial lesions 4–10 mm in diameter from the surrounding normal-looking white and gray matter. Furthermore, we examined how changes in agent properties, model parameters, and experimental conditions can influence imageability, identifying a set of conditions under which imaging of MS lesions might be feasible. Based on our results, we concluded that PET imaging has the potential to become a useful complementary method to MRI for MS diagnosis and therapy monitoring. |
| format | Article |
| id | doaj-art-36844e60e61f44639bcec57d10aa2e46 |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-36844e60e61f44639bcec57d10aa2e462025-02-03T05:59:23ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962011-01-01201110.1155/2011/953806953806Feasibility of Imaging Myelin Lesions in Multiple SclerosisMaria I. Zavodszky0John F. Graf1Cristina A. Tan Hehir2General Electric Global Research Center, 1 Research Circle, Niskayuna, NY 12309, USAGeneral Electric Global Research Center, 1 Research Circle, Niskayuna, NY 12309, USAGeneral Electric Global Research Center, 1 Research Circle, Niskayuna, NY 12309, USAThe goal of this study was to provide a feasibility assessment for PET imaging of multiple sclerosis (MS) lesions based on their decreased myelin content relative to the surrounding normal-appearing brain tissue. The imaging agent evaluated for this purpose is a molecule that binds strongly and specifically to myelin basic protein. Physiology-based pharmacokinetic modeling combined with PET image simulation applied to a brain model was used to examine whether such an agent would allow the differentiation of artificial lesions 4–10 mm in diameter from the surrounding normal-looking white and gray matter. Furthermore, we examined how changes in agent properties, model parameters, and experimental conditions can influence imageability, identifying a set of conditions under which imaging of MS lesions might be feasible. Based on our results, we concluded that PET imaging has the potential to become a useful complementary method to MRI for MS diagnosis and therapy monitoring.http://dx.doi.org/10.1155/2011/953806 |
| spellingShingle | Maria I. Zavodszky John F. Graf Cristina A. Tan Hehir Feasibility of Imaging Myelin Lesions in Multiple Sclerosis International Journal of Biomedical Imaging |
| title | Feasibility of Imaging Myelin Lesions in Multiple Sclerosis |
| title_full | Feasibility of Imaging Myelin Lesions in Multiple Sclerosis |
| title_fullStr | Feasibility of Imaging Myelin Lesions in Multiple Sclerosis |
| title_full_unstemmed | Feasibility of Imaging Myelin Lesions in Multiple Sclerosis |
| title_short | Feasibility of Imaging Myelin Lesions in Multiple Sclerosis |
| title_sort | feasibility of imaging myelin lesions in multiple sclerosis |
| url | http://dx.doi.org/10.1155/2011/953806 |
| work_keys_str_mv | AT mariaizavodszky feasibilityofimagingmyelinlesionsinmultiplesclerosis AT johnfgraf feasibilityofimagingmyelinlesionsinmultiplesclerosis AT cristinaatanhehir feasibilityofimagingmyelinlesionsinmultiplesclerosis |