Comparison of creatinine‐based methods for estimating glomerular filtration rate in patients with heart failure
Abstract Aims Glomerular filtration rate is an important factor in management of heart failure (HF). Our objective was to validate eight creatinine‐based equations for estimating glomerular filtration rate (eGFR) in an HF population against measured glomerular filtration rate. Methods and results On...
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| Format: | Article |
| Language: | English |
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Wiley
2020-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.12643 |
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| _version_ | 1832544393177858048 |
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| author | Anna Jonsson Ida Viklund Andreas Jonsson Fredrik Valham Ellinor Bergdahl Krister Lindmark Helena Norberg |
| author_facet | Anna Jonsson Ida Viklund Andreas Jonsson Fredrik Valham Ellinor Bergdahl Krister Lindmark Helena Norberg |
| author_sort | Anna Jonsson |
| collection | DOAJ |
| description | Abstract Aims Glomerular filtration rate is an important factor in management of heart failure (HF). Our objective was to validate eight creatinine‐based equations for estimating glomerular filtration rate (eGFR) in an HF population against measured glomerular filtration rate. Methods and results One hundred forty‐six HF patients (mean age 68 ± 13 years, mean left ventricular ejection fraction 45% ± 15) within a single‐centre hospital that underwent 51Cr‐EDTA clearance between 2010 and 2018 were included in this retrospective study. eGFR was estimated by means of Cockcroft–Gault ideal and actual weight, the Modification of Diet in Renal Disease Study (MDRD), simplified MDRD with isotope dilution mass spectroscopy traceable calibration, the Chronic Kidney Disease Epidemiology Collaboration, revised Lund–Malmö, full age spectrum, and the Berlin Initiative Study 1. Mean measured glomerular filtration rate was 42 mL/min/1.73 m2. Pearson's correlation coefficient (r) had the highest precision for MDRD (r = 0.9), followed by revised Lund–Malmö (r = 0.88). All equations except MDRD (mean difference −4.8%) resulted in an overestimation of the renal function. The accuracy was below 75% for all equations except MDRD. Conclusions None of the exclusively creatinine‐based methods was accurate in predicting eGFR in HF patients. Our findings suggest that more accurate methods are needed for determining eGFR in patients with HF. |
| format | Article |
| id | doaj-art-367fc134ce1d4587b12792004b9d2a95 |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Wiley |
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| series | ESC Heart Failure |
| spelling | doaj-art-367fc134ce1d4587b12792004b9d2a952025-02-03T10:25:46ZengWileyESC Heart Failure2055-58222020-06-01731150116010.1002/ehf2.12643Comparison of creatinine‐based methods for estimating glomerular filtration rate in patients with heart failureAnna Jonsson0Ida Viklund1Andreas Jonsson2Fredrik Valham3Ellinor Bergdahl4Krister Lindmark5Helena Norberg6Department of Public Health and Clinical Medicine Umeå University Umeå S‐901 87 SwedenDepartment of Pharmacology and Clinical Neuroscience Umeå University Umeå SwedenDepartment of Public Health and Clinical Medicine Umeå University Umeå S‐901 87 SwedenDepartment of Public Health and Clinical Medicine Umeå University Umeå S‐901 87 SwedenDepartment of Public Health and Clinical Medicine Umeå University Umeå S‐901 87 SwedenDepartment of Public Health and Clinical Medicine Umeå University Umeå S‐901 87 SwedenDepartment of Public Health and Clinical Medicine Umeå University Umeå S‐901 87 SwedenAbstract Aims Glomerular filtration rate is an important factor in management of heart failure (HF). Our objective was to validate eight creatinine‐based equations for estimating glomerular filtration rate (eGFR) in an HF population against measured glomerular filtration rate. Methods and results One hundred forty‐six HF patients (mean age 68 ± 13 years, mean left ventricular ejection fraction 45% ± 15) within a single‐centre hospital that underwent 51Cr‐EDTA clearance between 2010 and 2018 were included in this retrospective study. eGFR was estimated by means of Cockcroft–Gault ideal and actual weight, the Modification of Diet in Renal Disease Study (MDRD), simplified MDRD with isotope dilution mass spectroscopy traceable calibration, the Chronic Kidney Disease Epidemiology Collaboration, revised Lund–Malmö, full age spectrum, and the Berlin Initiative Study 1. Mean measured glomerular filtration rate was 42 mL/min/1.73 m2. Pearson's correlation coefficient (r) had the highest precision for MDRD (r = 0.9), followed by revised Lund–Malmö (r = 0.88). All equations except MDRD (mean difference −4.8%) resulted in an overestimation of the renal function. The accuracy was below 75% for all equations except MDRD. Conclusions None of the exclusively creatinine‐based methods was accurate in predicting eGFR in HF patients. Our findings suggest that more accurate methods are needed for determining eGFR in patients with HF.https://doi.org/10.1002/ehf2.12643Heart failureRenal functionEstimated glomerular filtration rateCreatinine |
| spellingShingle | Anna Jonsson Ida Viklund Andreas Jonsson Fredrik Valham Ellinor Bergdahl Krister Lindmark Helena Norberg Comparison of creatinine‐based methods for estimating glomerular filtration rate in patients with heart failure ESC Heart Failure Heart failure Renal function Estimated glomerular filtration rate Creatinine |
| title | Comparison of creatinine‐based methods for estimating glomerular filtration rate in patients with heart failure |
| title_full | Comparison of creatinine‐based methods for estimating glomerular filtration rate in patients with heart failure |
| title_fullStr | Comparison of creatinine‐based methods for estimating glomerular filtration rate in patients with heart failure |
| title_full_unstemmed | Comparison of creatinine‐based methods for estimating glomerular filtration rate in patients with heart failure |
| title_short | Comparison of creatinine‐based methods for estimating glomerular filtration rate in patients with heart failure |
| title_sort | comparison of creatinine based methods for estimating glomerular filtration rate in patients with heart failure |
| topic | Heart failure Renal function Estimated glomerular filtration rate Creatinine |
| url | https://doi.org/10.1002/ehf2.12643 |
| work_keys_str_mv | AT annajonsson comparisonofcreatininebasedmethodsforestimatingglomerularfiltrationrateinpatientswithheartfailure AT idaviklund comparisonofcreatininebasedmethodsforestimatingglomerularfiltrationrateinpatientswithheartfailure AT andreasjonsson comparisonofcreatininebasedmethodsforestimatingglomerularfiltrationrateinpatientswithheartfailure AT fredrikvalham comparisonofcreatininebasedmethodsforestimatingglomerularfiltrationrateinpatientswithheartfailure AT ellinorbergdahl comparisonofcreatininebasedmethodsforestimatingglomerularfiltrationrateinpatientswithheartfailure AT kristerlindmark comparisonofcreatininebasedmethodsforestimatingglomerularfiltrationrateinpatientswithheartfailure AT helenanorberg comparisonofcreatininebasedmethodsforestimatingglomerularfiltrationrateinpatientswithheartfailure |