Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure
Carotid-femoral pulse wave velocity (PWV) has emerged as the gold standard for non-invasive evaluation of aortic stiffness; absence of standardized methodologies of study and lack of normal and reference values have limited a wider clinical implementation. This work was carried out in a Uruguayan (S...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/169359 |
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| author | Ignacio Farro Daniel Bia Yanina Zócalo Juan Torrado Federico Farro Lucía Florio Alicia Olascoaga Walter Alallón Ricardo Lluberas Ricardo L. Armentano |
| author_facet | Ignacio Farro Daniel Bia Yanina Zócalo Juan Torrado Federico Farro Lucía Florio Alicia Olascoaga Walter Alallón Ricardo Lluberas Ricardo L. Armentano |
| author_sort | Ignacio Farro |
| collection | DOAJ |
| description | Carotid-femoral pulse wave velocity (PWV) has emerged as the gold standard for non-invasive evaluation of aortic stiffness; absence of standardized methodologies of study and lack of normal and reference values have limited a wider clinical implementation. This work was carried out in a Uruguayan (South American) population in order to characterize normal, reference, and threshold levels of PWV considering normal age-related changes in PWV and the prevailing blood pressure level during the study. A conservative approach was used, and we excluded symptomatic subjects; subjects with history of cardiovascular (CV) disease, diabetes mellitus or renal failure; subjects with traditional CV risk factors (other than age and gender); asymptomatic subjects with atherosclerotic plaques in carotid arteries; patients taking anti-hypertensives or lipid-lowering medications. The included subjects (n=429) were categorized according to the age decade and the blood pressure levels (at study time). All subjects represented the “reference population”; the group of subjects with optimal/normal blood pressures levels at study time represented the “normal population.” Results. Normal and reference PWV levels were obtained. Differences in PWV levels and aging-associated changes were obtained. The obtained data could be used to define vascular aging and abnormal or disease-related arterial changes. |
| format | Article |
| id | doaj-art-3673cbcc268c4f37983a7c863b6b3329 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-3673cbcc268c4f37983a7c863b6b33292025-02-03T05:46:04ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/169359169359Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood PressureIgnacio Farro0Daniel Bia1Yanina Zócalo2Juan Torrado3Federico Farro4Lucía Florio5Alicia Olascoaga6Walter Alallón7Ricardo Lluberas8Ricardo L. Armentano9Physiology Department, School of Medicine, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, UruguayPhysiology Department, School of Medicine, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, UruguayPhysiology Department, School of Medicine, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, UruguayPhysiology Department, School of Medicine, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, UruguayPhysiology Department, School of Medicine, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, UruguayCardiology Department, School of Medicine, CUiiDARTE and Cardiovascular Centre, Clinical Hospital, Republic University, Avenida Italia s/n, 11600 Montevideo, UruguayClinical Laboratory Department, School of Medicine, Clinical Hospital, Republic University, Avenida Italia s/n, 11600 Montevideo, UruguayClinical Laboratory Department, School of Medicine, Clinical Hospital, Republic University, Avenida Italia s/n, 11600 Montevideo, UruguayCardiology Department, School of Medicine, CUiiDARTE and Cardiovascular Centre, Clinical Hospital, Republic University, Avenida Italia s/n, 11600 Montevideo, UruguayPhysiology Department, School of Medicine, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, UruguayCarotid-femoral pulse wave velocity (PWV) has emerged as the gold standard for non-invasive evaluation of aortic stiffness; absence of standardized methodologies of study and lack of normal and reference values have limited a wider clinical implementation. This work was carried out in a Uruguayan (South American) population in order to characterize normal, reference, and threshold levels of PWV considering normal age-related changes in PWV and the prevailing blood pressure level during the study. A conservative approach was used, and we excluded symptomatic subjects; subjects with history of cardiovascular (CV) disease, diabetes mellitus or renal failure; subjects with traditional CV risk factors (other than age and gender); asymptomatic subjects with atherosclerotic plaques in carotid arteries; patients taking anti-hypertensives or lipid-lowering medications. The included subjects (n=429) were categorized according to the age decade and the blood pressure levels (at study time). All subjects represented the “reference population”; the group of subjects with optimal/normal blood pressures levels at study time represented the “normal population.” Results. Normal and reference PWV levels were obtained. Differences in PWV levels and aging-associated changes were obtained. The obtained data could be used to define vascular aging and abnormal or disease-related arterial changes.http://dx.doi.org/10.1155/2012/169359 |
| spellingShingle | Ignacio Farro Daniel Bia Yanina Zócalo Juan Torrado Federico Farro Lucía Florio Alicia Olascoaga Walter Alallón Ricardo Lluberas Ricardo L. Armentano Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure International Journal of Hypertension |
| title | Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure |
| title_full | Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure |
| title_fullStr | Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure |
| title_full_unstemmed | Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure |
| title_short | Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure |
| title_sort | pulse wave velocity as marker of preclinical arterial disease reference levels in a uruguayan population considering wave detection algorithms path lengths aging and blood pressure |
| url | http://dx.doi.org/10.1155/2012/169359 |
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