Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C
Hepatitis C virus (HCV) can escape from innate and adaptive immunity, making the immune response ineffective. Human leukocyte antigen E (HLA-E) might regulate the antiviral function of immune response and contribute to the persistence of HCV and the severity of liver disease. This study aimed to eva...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2563563 |
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| author | Roberta C. Araújo Fabricio C. Dias Bruna C. Bertol Deisy M. Silva Patrícia H. Almeida Andreza C. Teixeira Fernanda F. Souza Marcia G. Villanova Leandra N. Z. Ramalho Eduardo A. Donadi Ana L. C. Martinelli |
| author_facet | Roberta C. Araújo Fabricio C. Dias Bruna C. Bertol Deisy M. Silva Patrícia H. Almeida Andreza C. Teixeira Fernanda F. Souza Marcia G. Villanova Leandra N. Z. Ramalho Eduardo A. Donadi Ana L. C. Martinelli |
| author_sort | Roberta C. Araújo |
| collection | DOAJ |
| description | Hepatitis C virus (HCV) can escape from innate and adaptive immunity, making the immune response ineffective. Human leukocyte antigen E (HLA-E) might regulate the antiviral function of immune response and contribute to the persistence of HCV and the severity of liver disease. This study aimed to evaluate the expression of HLA-E in the liver and its association with the severity of liver disease in HCV patients. We performed a retrospective analysis of liver biopsies from 125 HCV patients and from 20 control subjects without liver disease. Liver biopsies were reviewed and classified according to severity of fibrosis and inflammatory activity. The pathologist assessed the magnitude of HLA-E expression in a semiquantitative way, attributing scores from 0 to 3. Immunohistochemistry showed positive for HLA-E in hepatocyte and Kupffer cells. The rate of HLA-E positivity in hepatocytes and Kupffer cells was significantly higher in HCV patients compared to controls. The liver samples classified as severe fibrosis and necroinflammatory activity presented greater expression of HLA-E on Kupffer cells and hepatocytes, with a significant linear association. It indicates that HLA-E expression may have an immunomodulatory effect and a possible role in the severity of liver disease in chronic hepatitis C. |
| format | Article |
| id | doaj-art-366e08ee9dc6437b8230bce2ee1011fa |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-366e08ee9dc6437b8230bce2ee1011fa2025-02-03T01:01:36ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/25635632563563Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis CRoberta C. Araújo0Fabricio C. Dias1Bruna C. Bertol2Deisy M. Silva3Patrícia H. Almeida4Andreza C. Teixeira5Fernanda F. Souza6Marcia G. Villanova7Leandra N. Z. Ramalho8Eduardo A. Donadi9Ana L. C. Martinelli10Gastroenterology Division, Ribeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, BrazilRibeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, BrazilRibeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, BrazilPathology Department, Ribeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, BrazilRibeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, BrazilGastroenterology Division, Ribeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, BrazilGastroenterology Division, Ribeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, BrazilGastroenterology Division, Ribeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, BrazilPathology Department, Ribeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, BrazilImmunology Division, Ribeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, BrazilGastroenterology Division, Ribeirão Preto Medical School, University of São Paulo, 14048-900 Ribeirão Preto, SP, BrazilHepatitis C virus (HCV) can escape from innate and adaptive immunity, making the immune response ineffective. Human leukocyte antigen E (HLA-E) might regulate the antiviral function of immune response and contribute to the persistence of HCV and the severity of liver disease. This study aimed to evaluate the expression of HLA-E in the liver and its association with the severity of liver disease in HCV patients. We performed a retrospective analysis of liver biopsies from 125 HCV patients and from 20 control subjects without liver disease. Liver biopsies were reviewed and classified according to severity of fibrosis and inflammatory activity. The pathologist assessed the magnitude of HLA-E expression in a semiquantitative way, attributing scores from 0 to 3. Immunohistochemistry showed positive for HLA-E in hepatocyte and Kupffer cells. The rate of HLA-E positivity in hepatocytes and Kupffer cells was significantly higher in HCV patients compared to controls. The liver samples classified as severe fibrosis and necroinflammatory activity presented greater expression of HLA-E on Kupffer cells and hepatocytes, with a significant linear association. It indicates that HLA-E expression may have an immunomodulatory effect and a possible role in the severity of liver disease in chronic hepatitis C.http://dx.doi.org/10.1155/2018/2563563 |
| spellingShingle | Roberta C. Araújo Fabricio C. Dias Bruna C. Bertol Deisy M. Silva Patrícia H. Almeida Andreza C. Teixeira Fernanda F. Souza Marcia G. Villanova Leandra N. Z. Ramalho Eduardo A. Donadi Ana L. C. Martinelli Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C Journal of Immunology Research |
| title | Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C |
| title_full | Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C |
| title_fullStr | Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C |
| title_full_unstemmed | Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C |
| title_short | Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C |
| title_sort | liver hla e expression is associated with severity of liver disease in chronic hepatitis c |
| url | http://dx.doi.org/10.1155/2018/2563563 |
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