Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab
Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving small vessels with deposition of immunoglobulin A (IgA) complexes, usually affecting children. Compared with children, HSP in adults is more severe and frequently associated with cancer. We report the case of a 49-year-old woman with...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/619218 |
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| author | Taylor Pindi Sala Jean-Marie Michot Renaud Snanoudj Marion Dollat Emmanuel Estève Bernadette Marie Yacine Taoufik Jean-François Delfraissy Thierry Lazure Olivier Lambotte |
| author_facet | Taylor Pindi Sala Jean-Marie Michot Renaud Snanoudj Marion Dollat Emmanuel Estève Bernadette Marie Yacine Taoufik Jean-François Delfraissy Thierry Lazure Olivier Lambotte |
| author_sort | Taylor Pindi Sala |
| collection | DOAJ |
| description | Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving small vessels with deposition of immunoglobulin A (IgA) complexes, usually affecting children. Compared with children, HSP in adults is more severe and frequently associated with cancer. We report the case of a 49-year-old woman with medical history of kidney transplantation for segmental glomerular hyalinosis. Eight years after the transplantation, while taking combined immunosuppressive therapy with tacrolimus and azathioprine indicated for the prevention against transplant rejection, she developed a Henoch-Schönlein purpura. Vasculitis involves skin and sciatic peroneal nerve and she received systemic corticosteroid treatment. Because of four relapses and corticosteroid dependence, the patient was treated with rituximab (two intravenous infusions of 1000 mg given two weeks apart). Successful outcome was observed along two years of follow-up. This new case of successful use of rituximab in HSP promotes more investigations of this treatment in clinical trials. |
| format | Article |
| id | doaj-art-3667b45c8cf1470281c499e0f2112a83 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-3667b45c8cf1470281c499e0f2112a832025-02-03T05:46:46ZengWileyCase Reports in Medicine1687-96271687-96352014-01-01201410.1155/2014/619218619218Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with RituximabTaylor Pindi Sala0Jean-Marie Michot1Renaud Snanoudj2Marion Dollat3Emmanuel Estève4Bernadette Marie5Yacine Taoufik6Jean-François Delfraissy7Thierry Lazure8Olivier Lambotte9Internal Medicine Department, Assistance Publique-Hôpitaux de Paris, Bicêtre Hospital, 94275 Le Kremlin-Bicêtre, FranceInternal Medicine Department, Assistance Publique-Hôpitaux de Paris, Bicêtre Hospital, 94275 Le Kremlin-Bicêtre, FranceDepartment of Nephrology and Adult Renal Transplantation, Assistance Publique-Hôpitaux de Paris, Necker Enfants-Malades Hospital, 75015 Paris, FranceInternal Medicine Department, Assistance Publique-Hôpitaux de Paris, Bicêtre Hospital, 94275 Le Kremlin-Bicêtre, FranceInternal Medicine Department, Assistance Publique-Hôpitaux de Paris, Bicêtre Hospital, 94275 Le Kremlin-Bicêtre, FranceFaculty of Medicine Paris-Sud, 94276 Le Kremlin-Bicêtre Cedex, FranceFaculty of Medicine Paris-Sud, 94276 Le Kremlin-Bicêtre Cedex, FranceInternal Medicine Department, Assistance Publique-Hôpitaux de Paris, Bicêtre Hospital, 94275 Le Kremlin-Bicêtre, FranceDepartment of Pathology, Assistance Publique-Hôpitaux de Paris, Bicêtre Hospital, 94275 Le Kremlin-Bicêtre, FranceInternal Medicine Department, Assistance Publique-Hôpitaux de Paris, Bicêtre Hospital, 94275 Le Kremlin-Bicêtre, FranceHenoch-Schönlein purpura (HSP) is a systemic vasculitis involving small vessels with deposition of immunoglobulin A (IgA) complexes, usually affecting children. Compared with children, HSP in adults is more severe and frequently associated with cancer. We report the case of a 49-year-old woman with medical history of kidney transplantation for segmental glomerular hyalinosis. Eight years after the transplantation, while taking combined immunosuppressive therapy with tacrolimus and azathioprine indicated for the prevention against transplant rejection, she developed a Henoch-Schönlein purpura. Vasculitis involves skin and sciatic peroneal nerve and she received systemic corticosteroid treatment. Because of four relapses and corticosteroid dependence, the patient was treated with rituximab (two intravenous infusions of 1000 mg given two weeks apart). Successful outcome was observed along two years of follow-up. This new case of successful use of rituximab in HSP promotes more investigations of this treatment in clinical trials.http://dx.doi.org/10.1155/2014/619218 |
| spellingShingle | Taylor Pindi Sala Jean-Marie Michot Renaud Snanoudj Marion Dollat Emmanuel Estève Bernadette Marie Yacine Taoufik Jean-François Delfraissy Thierry Lazure Olivier Lambotte Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab Case Reports in Medicine |
| title | Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab |
| title_full | Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab |
| title_fullStr | Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab |
| title_full_unstemmed | Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab |
| title_short | Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab |
| title_sort | successful outcome of a corticodependent henoch schonlein purpura adult with rituximab |
| url | http://dx.doi.org/10.1155/2014/619218 |
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