Role of Apolipoprotein E in Anxiety
Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve hist...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2007/91236 |
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| Summary: | Anxiety is most common among Alzheimer's disease (AD) patients with an age
at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for
developing AD at an earlier age and might contribute to this effect. In
mice, apoE plays a role in the regulation of anxiety, which might involve
histamine receptor-mediated signaling and steroidogenesis in the adrenal
gland. In addition, human apoE isoforms have differential effects on anxiety
in adult mice lacking apoE and probable AD patients. Compared to wild-type
mice, mice lacking apoE and apoE4 mice showed pathological alterations in
the central nucleus of the amygdala, which is involved in regulation of
anxiety. ApoE4, but not mice lacking apoE, or apoE3 mice showed impaired
dexamethasone suppression of plasma corticosterone. Understanding how apoE
modulates measures of anxiety might help the developments of therapeutic
targets to reduce or even prevent measures of anxiety in health and in
dementing illnesses. |
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| ISSN: | 2090-5904 1687-5443 |