Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus Cohort
STUDY AIMS: Sarcopenia is a progressive, age-related loss of muscle mass, strength and function. Given the ageing population and the adverse outcomes associated with sarcopenia, monitoring its epidemiology is particularly important. This study aimed to describe sarcopenia prevalence, 5-year inciden...
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2025-01-01
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| Series: | Swiss Medical Weekly |
| Online Access: | https://smw.ch/index.php/smw/article/view/4034 |
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| author | Colin Vendrami Elena Gonzalez Rodriguez Guillaume Gatineau Peter Vollenweider Pedro Marques-Vidal Olivier Lamy Didier Hans Enisa Shevroja |
| author_facet | Colin Vendrami Elena Gonzalez Rodriguez Guillaume Gatineau Peter Vollenweider Pedro Marques-Vidal Olivier Lamy Didier Hans Enisa Shevroja |
| author_sort | Colin Vendrami |
| collection | DOAJ |
| description |
STUDY AIMS: Sarcopenia is a progressive, age-related loss of muscle mass, strength and function. Given the ageing population and the adverse outcomes associated with sarcopenia, monitoring its epidemiology is particularly important. This study aimed to describe sarcopenia prevalence, 5-year incidence and agreement between definitions using the latest operational criteria in Swiss postmenopausal women.
METHODS: Postmenopausal women from the last 5 years of the CoLaus/OsteoLaus prospective population-based cohort were included based on complete case analysis (April 2015 to October 2022; Lausanne, Switzerland). We assessed appendicular lean mass via Dual X-ray Absorptiometry (GE Lunar iDXA), handgrip strength using a Jamar Dynamometer and 6-metre gait speed at multiple visits. Sarcopenia was defined based on handgrip strength and/or appendicular lean mass and/or gait speed using 11 definitions, including that from the European Working Group on Sarcopenia in Older People (EWGSOPII, 2019). Prevalence was measured as the number and rate of sarcopenic cases at the last visit, while incidence was measured as the number and rate of new sarcopenic cases over 2.5 or 5 years.
RESULTS: A total of 930 women were included, with a mean (standard deviation) age of 72.9 (6.9) years, BMI of 25.7 (4.8) kg/m2, appendicular lean mass 16.8 (2.5) kg, handgrip strength 21.2 (5.5) kg, gait speed 1.1 (0.2) m/s. Sarcopenia prevalence based on EWGSOPII definitions ranged from 2.2% to 5.7%, while other definitions varied from 0.5% to 13.4%. The 5-year incidence rates based on EWGSOPII were 1.9% to 4.7%. Prevalence and incidence increased significantly between the lowest and highest age tertiles (Fisher’s exact test, p <0.05) for most definitions. Agreement between definitions was predominantly “none” or “minimal” according to the Cohen Kappa score.
CONCLUSION: This population-based cohort of postmenopausal women highlights an increase in sarcopenia prevalence and incidence beginning in the seventh decade of life, underscoring the accelerated decline in muscle health with age. The minimal agreement between the definitions highlights the need for a consensus, which would improve future research and clinical implementations.
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| format | Article |
| id | doaj-art-3665c3300d004bf5abd83f386add0aa2 |
| institution | Kabale University |
| issn | 1424-3997 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj-art-3665c3300d004bf5abd83f386add0aa22025-01-24T20:29:55ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972025-01-01155110.57187/s.4034Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus CohortColin Vendrami0Elena Gonzalez Rodriguez1Guillaume Gatineau2Peter Vollenweider3Pedro Marques-Vidal4Olivier Lamy5Didier HansEnisa Shevroja6Interdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department, Lausanne University Hospital and University of LausanneInterdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department, Lausanne University Hospital and University of Lausanne, SwitzerlandInterdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department, Lausanne University Hospital and University of Lausanne, SwitzerlandDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, SwitzerlandDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, SwitzerlandDepartment of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, SwitzerlandInterdisciplinary Center of Bone Diseases, Rheumatology Unit, Bone and Joint Department, Lausanne University Hospital and University of Lausanne, Switzerland STUDY AIMS: Sarcopenia is a progressive, age-related loss of muscle mass, strength and function. Given the ageing population and the adverse outcomes associated with sarcopenia, monitoring its epidemiology is particularly important. This study aimed to describe sarcopenia prevalence, 5-year incidence and agreement between definitions using the latest operational criteria in Swiss postmenopausal women. METHODS: Postmenopausal women from the last 5 years of the CoLaus/OsteoLaus prospective population-based cohort were included based on complete case analysis (April 2015 to October 2022; Lausanne, Switzerland). We assessed appendicular lean mass via Dual X-ray Absorptiometry (GE Lunar iDXA), handgrip strength using a Jamar Dynamometer and 6-metre gait speed at multiple visits. Sarcopenia was defined based on handgrip strength and/or appendicular lean mass and/or gait speed using 11 definitions, including that from the European Working Group on Sarcopenia in Older People (EWGSOPII, 2019). Prevalence was measured as the number and rate of sarcopenic cases at the last visit, while incidence was measured as the number and rate of new sarcopenic cases over 2.5 or 5 years. RESULTS: A total of 930 women were included, with a mean (standard deviation) age of 72.9 (6.9) years, BMI of 25.7 (4.8) kg/m2, appendicular lean mass 16.8 (2.5) kg, handgrip strength 21.2 (5.5) kg, gait speed 1.1 (0.2) m/s. Sarcopenia prevalence based on EWGSOPII definitions ranged from 2.2% to 5.7%, while other definitions varied from 0.5% to 13.4%. The 5-year incidence rates based on EWGSOPII were 1.9% to 4.7%. Prevalence and incidence increased significantly between the lowest and highest age tertiles (Fisher’s exact test, p <0.05) for most definitions. Agreement between definitions was predominantly “none” or “minimal” according to the Cohen Kappa score. CONCLUSION: This population-based cohort of postmenopausal women highlights an increase in sarcopenia prevalence and incidence beginning in the seventh decade of life, underscoring the accelerated decline in muscle health with age. The minimal agreement between the definitions highlights the need for a consensus, which would improve future research and clinical implementations. https://smw.ch/index.php/smw/article/view/4034 |
| spellingShingle | Colin Vendrami Elena Gonzalez Rodriguez Guillaume Gatineau Peter Vollenweider Pedro Marques-Vidal Olivier Lamy Didier Hans Enisa Shevroja Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus Cohort Swiss Medical Weekly |
| title | Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus Cohort |
| title_full | Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus Cohort |
| title_fullStr | Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus Cohort |
| title_full_unstemmed | Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus Cohort |
| title_short | Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus Cohort |
| title_sort | prevalence and incidence of sarcopenia in swiss postmenopausal women findings from the osteolaus cohort |
| url | https://smw.ch/index.php/smw/article/view/4034 |
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