Bacteria in Cancer Therapy: Renaissance of an Old Concept
The rising incidence of cancer cases worldwide generates an urgent need of novel treatment options. Applying bacteria may represent a valuable therapeutic variant that is intensively investigated nowadays. Interestingly, the idea to apply bacteria wittingly or unwittingly dates back to ancient times...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2016/8451728 |
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| _version_ | 1832560798628577280 |
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| author | Sebastian Felgner Dino Kocijancic Michael Frahm Siegfried Weiss |
| author_facet | Sebastian Felgner Dino Kocijancic Michael Frahm Siegfried Weiss |
| author_sort | Sebastian Felgner |
| collection | DOAJ |
| description | The rising incidence of cancer cases worldwide generates an urgent need of novel treatment options. Applying bacteria may represent a valuable therapeutic variant that is intensively investigated nowadays. Interestingly, the idea to apply bacteria wittingly or unwittingly dates back to ancient times and was revived in the 19th century mainly by the pioneer William Coley. This review summarizes and compares the results of the past 150 years in bacteria mediated tumor therapy from preclinical to clinical studies. Lessons we have learned from the past provide a solid foundation on which to base future efforts. In this regard, several perspectives are discussed by which bacteria in addition to their intrinsic antitumor effect can be used as vector systems that shuttle therapeutic compounds into the tumor. Strategic solutions like these provide a sound and more apt exploitation of bacteria that may overcome limitations of conventional therapies. |
| format | Article |
| id | doaj-art-365f62f99d164d91a4e59bd13d429315 |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-365f62f99d164d91a4e59bd13d4293152025-02-03T01:26:39ZengWileyInternational Journal of Microbiology1687-918X1687-91982016-01-01201610.1155/2016/84517288451728Bacteria in Cancer Therapy: Renaissance of an Old ConceptSebastian Felgner0Dino Kocijancic1Michael Frahm2Siegfried Weiss3Department of Molecular Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, GermanyDepartment of Molecular Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, GermanyDepartment of Molecular Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, GermanyDepartment of Molecular Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, GermanyThe rising incidence of cancer cases worldwide generates an urgent need of novel treatment options. Applying bacteria may represent a valuable therapeutic variant that is intensively investigated nowadays. Interestingly, the idea to apply bacteria wittingly or unwittingly dates back to ancient times and was revived in the 19th century mainly by the pioneer William Coley. This review summarizes and compares the results of the past 150 years in bacteria mediated tumor therapy from preclinical to clinical studies. Lessons we have learned from the past provide a solid foundation on which to base future efforts. In this regard, several perspectives are discussed by which bacteria in addition to their intrinsic antitumor effect can be used as vector systems that shuttle therapeutic compounds into the tumor. Strategic solutions like these provide a sound and more apt exploitation of bacteria that may overcome limitations of conventional therapies.http://dx.doi.org/10.1155/2016/8451728 |
| spellingShingle | Sebastian Felgner Dino Kocijancic Michael Frahm Siegfried Weiss Bacteria in Cancer Therapy: Renaissance of an Old Concept International Journal of Microbiology |
| title | Bacteria in Cancer Therapy: Renaissance of an Old Concept |
| title_full | Bacteria in Cancer Therapy: Renaissance of an Old Concept |
| title_fullStr | Bacteria in Cancer Therapy: Renaissance of an Old Concept |
| title_full_unstemmed | Bacteria in Cancer Therapy: Renaissance of an Old Concept |
| title_short | Bacteria in Cancer Therapy: Renaissance of an Old Concept |
| title_sort | bacteria in cancer therapy renaissance of an old concept |
| url | http://dx.doi.org/10.1155/2016/8451728 |
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