The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction
A variety of genetic approaches, including twin studies, linkage studies, and candidate gene studies, has established a firm genetic basis for addiction. However, there has been difficulty identifying the precise genes that underlie addiction liability using these approaches. This situation became e...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/9803764 |
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| author | Dawn E. Muskiewicz George R. Uhl F. Scott Hall |
| author_facet | Dawn E. Muskiewicz George R. Uhl F. Scott Hall |
| author_sort | Dawn E. Muskiewicz |
| collection | DOAJ |
| description | A variety of genetic approaches, including twin studies, linkage studies, and candidate gene studies, has established a firm genetic basis for addiction. However, there has been difficulty identifying the precise genes that underlie addiction liability using these approaches. This situation became especially clear in genome-wide association studies (GWAS) of addiction. Moreover, the results of GWAS brought into clarity many of the shortcomings of those early genetic approaches. GWAS studies stripped away those preconceived notions, examining genes that would not previously have been considered in the study of addiction, consequently creating a shift in our understanding. Most importantly, those studies implicated a class of genes that had not previously been considered in the study of addiction genetics: cell adhesion molecules (CAMs). Considering the well-documented evidence supporting a role for various CAMs in synaptic plasticity, axonal growth, and regeneration, it is not surprising that allelic variation in CAM genes might also play a role in addiction liability. This review focuses on the role of various cell adhesion molecules in neuroplasticity that might contribute to addictive processes and emphasizes the importance of ongoing research on CAM genes that have been implicated in addiction by GWAS. |
| format | Article |
| id | doaj-art-3656551342f9426395c4f92e3b70b960 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-3656551342f9426395c4f92e3b70b9602025-02-03T06:13:48ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/98037649803764The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in AddictionDawn E. Muskiewicz0George R. Uhl1F. Scott Hall2Department of Pharmacology and Experimental Therapeutics, University of Toledo College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USAMolecular Neurobiology Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, USADepartment of Pharmacology and Experimental Therapeutics, University of Toledo College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USAA variety of genetic approaches, including twin studies, linkage studies, and candidate gene studies, has established a firm genetic basis for addiction. However, there has been difficulty identifying the precise genes that underlie addiction liability using these approaches. This situation became especially clear in genome-wide association studies (GWAS) of addiction. Moreover, the results of GWAS brought into clarity many of the shortcomings of those early genetic approaches. GWAS studies stripped away those preconceived notions, examining genes that would not previously have been considered in the study of addiction, consequently creating a shift in our understanding. Most importantly, those studies implicated a class of genes that had not previously been considered in the study of addiction genetics: cell adhesion molecules (CAMs). Considering the well-documented evidence supporting a role for various CAMs in synaptic plasticity, axonal growth, and regeneration, it is not surprising that allelic variation in CAM genes might also play a role in addiction liability. This review focuses on the role of various cell adhesion molecules in neuroplasticity that might contribute to addictive processes and emphasizes the importance of ongoing research on CAM genes that have been implicated in addiction by GWAS.http://dx.doi.org/10.1155/2018/9803764 |
| spellingShingle | Dawn E. Muskiewicz George R. Uhl F. Scott Hall The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction Neural Plasticity |
| title | The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction |
| title_full | The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction |
| title_fullStr | The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction |
| title_full_unstemmed | The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction |
| title_short | The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction |
| title_sort | role of cell adhesion molecule genes regulating neuroplasticity in addiction |
| url | http://dx.doi.org/10.1155/2018/9803764 |
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