Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants
Background. Prostate cancer is the most common noncutaneous cancer and second leading cause of cancer-related mortality in men in the US. Growing evidence suggests that oxidative stress is involved in prostate cancer. Methods. In this study, thioredoxin 1 (Trx 1), an enzyme and subcellular indicator...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2015/728046 |
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| author | Terrence M. Vance Gissou Azabdaftari Elena A. Pop Sang Gil Lee L. Joseph Su Elizabeth T. H. Fontham Jeannette T. Bensen Susan E. Steck Lenore Arab James L. Mohler Ming-Hui Chen Sung I. Koo Ock K. Chun |
| author_facet | Terrence M. Vance Gissou Azabdaftari Elena A. Pop Sang Gil Lee L. Joseph Su Elizabeth T. H. Fontham Jeannette T. Bensen Susan E. Steck Lenore Arab James L. Mohler Ming-Hui Chen Sung I. Koo Ock K. Chun |
| author_sort | Terrence M. Vance |
| collection | DOAJ |
| description | Background. Prostate cancer is the most common noncutaneous cancer and second leading cause of cancer-related mortality in men in the US. Growing evidence suggests that oxidative stress is involved in prostate cancer. Methods. In this study, thioredoxin 1 (Trx 1), an enzyme and subcellular indicator of redox status, was measured in prostate biopsy tissue from 55 men from the North Carolina-Louisiana Prostate Cancer Project. A pathologist blindly scored levels of Trx 1. The association between Trx 1 and the Gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidant intake was determined using Fisher’s exact test. Results. Trx 1 levels in benign prostate tissue in men with incident prostate cancer were positively associated with the Gleason score (P=0.01) and inversely associated with dietary antioxidant intake (P=0.03). In prostate cancer tissue, Trx 1 levels were associated with erythrocyte glutathione peroxidase activity (P=0.01). No association was found for other erythrocyte enzymes. Greater Gleason score of malignant tissue corresponds to a greater difference in Trx 1 levels between malignant and benign tissue (P=0.04). Conclusion. These results suggest that the redox status of prostate tissue is associated with prostate cancer grade and both endogenous and exogenous antioxidants. |
| format | Article |
| id | doaj-art-364d09306d2c4b9f9f538814ba60b74b |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-364d09306d2c4b9f9f538814ba60b74b2025-02-03T01:22:35ZengWileyProstate Cancer2090-31112090-312X2015-01-01201510.1155/2015/728046728046Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary AntioxidantsTerrence M. Vance0Gissou Azabdaftari1Elena A. Pop2Sang Gil Lee3L. Joseph Su4Elizabeth T. H. Fontham5Jeannette T. Bensen6Susan E. Steck7Lenore Arab8James L. Mohler9Ming-Hui Chen10Sung I. Koo11Ock K. Chun12Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USARoswell Park Cancer Institute, Buffalo, NY 14263, USARoswell Park Cancer Institute, Buffalo, NY 14263, USADepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USAEpidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USASchool of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USASchool of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Epidemiology and Biostatistics, Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USADavid Geffen School of Medicine, University of California, Los Angeles, CA 90095, USARoswell Park Cancer Institute, Buffalo, NY 14263, USADepartment of Statistics, University of Connecticut, Storrs, CT 06269, USADepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USADepartment of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USABackground. Prostate cancer is the most common noncutaneous cancer and second leading cause of cancer-related mortality in men in the US. Growing evidence suggests that oxidative stress is involved in prostate cancer. Methods. In this study, thioredoxin 1 (Trx 1), an enzyme and subcellular indicator of redox status, was measured in prostate biopsy tissue from 55 men from the North Carolina-Louisiana Prostate Cancer Project. A pathologist blindly scored levels of Trx 1. The association between Trx 1 and the Gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidant intake was determined using Fisher’s exact test. Results. Trx 1 levels in benign prostate tissue in men with incident prostate cancer were positively associated with the Gleason score (P=0.01) and inversely associated with dietary antioxidant intake (P=0.03). In prostate cancer tissue, Trx 1 levels were associated with erythrocyte glutathione peroxidase activity (P=0.01). No association was found for other erythrocyte enzymes. Greater Gleason score of malignant tissue corresponds to a greater difference in Trx 1 levels between malignant and benign tissue (P=0.04). Conclusion. These results suggest that the redox status of prostate tissue is associated with prostate cancer grade and both endogenous and exogenous antioxidants.http://dx.doi.org/10.1155/2015/728046 |
| spellingShingle | Terrence M. Vance Gissou Azabdaftari Elena A. Pop Sang Gil Lee L. Joseph Su Elizabeth T. H. Fontham Jeannette T. Bensen Susan E. Steck Lenore Arab James L. Mohler Ming-Hui Chen Sung I. Koo Ock K. Chun Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants Prostate Cancer |
| title | Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants |
| title_full | Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants |
| title_fullStr | Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants |
| title_full_unstemmed | Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants |
| title_short | Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants |
| title_sort | thioredoxin 1 in prostate tissue is associated with gleason score erythrocyte antioxidant enzyme activity and dietary antioxidants |
| url | http://dx.doi.org/10.1155/2015/728046 |
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