Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel
Neurogenesis occurs in the adult mammalian hippocampus, a region of the brain important for learning and memory. Hibernation in Siberian ground squirrels provides a natural model to study mitosis as the rapid fall in body temperature in 24 h (from 35-36°C to +4–6°C) permits accumulation of mitotic c...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/867525 |
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| author | Victor I. Popov Igor V. Kraev Dmitri A. Ignat'ev Michael G. Stewart |
| author_facet | Victor I. Popov Igor V. Kraev Dmitri A. Ignat'ev Michael G. Stewart |
| author_sort | Victor I. Popov |
| collection | DOAJ |
| description | Neurogenesis occurs in the adult mammalian hippocampus, a region of the brain important for learning and memory. Hibernation in Siberian ground squirrels provides a natural model to study mitosis as the rapid fall in body temperature in 24 h (from 35-36°C to +4–6°C) permits accumulation of mitotic cells at different stages of the cell cycle. Histological methods used to study adult neurogenesis are limited largely to fixed tissue, and the mitotic state elucidated depends on the specific phase of mitosis at the time of day. However, using an immunohistochemical study of doublecortin (DCX) and BrdU-labelled neurons, we demonstrate that the dentate gyrus of the ground squirrel hippocampus contains a population of immature cells which appear to possess mitotic activity. Our data suggest that doublecortin-labelled immature cells exist in a mitotic state and may represent a renewable pool for generation of new neurons within the dentate gyrus. |
| format | Article |
| id | doaj-art-36435e5d17c14976a9cb238daae56b32 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-36435e5d17c14976a9cb238daae56b322025-02-03T01:04:46ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/867525867525Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground SquirrelVictor I. Popov0Igor V. Kraev1Dmitri A. Ignat'ev2Michael G. Stewart3Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290, RussiaDepartment of Life Sciences, Faculty of Science, The Open University, Walton Hall, Milton Keynes MK7 6AA, UKInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290, RussiaInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290, RussiaNeurogenesis occurs in the adult mammalian hippocampus, a region of the brain important for learning and memory. Hibernation in Siberian ground squirrels provides a natural model to study mitosis as the rapid fall in body temperature in 24 h (from 35-36°C to +4–6°C) permits accumulation of mitotic cells at different stages of the cell cycle. Histological methods used to study adult neurogenesis are limited largely to fixed tissue, and the mitotic state elucidated depends on the specific phase of mitosis at the time of day. However, using an immunohistochemical study of doublecortin (DCX) and BrdU-labelled neurons, we demonstrate that the dentate gyrus of the ground squirrel hippocampus contains a population of immature cells which appear to possess mitotic activity. Our data suggest that doublecortin-labelled immature cells exist in a mitotic state and may represent a renewable pool for generation of new neurons within the dentate gyrus.http://dx.doi.org/10.1155/2011/867525 |
| spellingShingle | Victor I. Popov Igor V. Kraev Dmitri A. Ignat'ev Michael G. Stewart Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel Neural Plasticity |
| title | Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel |
| title_full | Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel |
| title_fullStr | Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel |
| title_full_unstemmed | Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel |
| title_short | Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel |
| title_sort | suspension of mitotic activity in dentate gyrus of the hibernating ground squirrel |
| url | http://dx.doi.org/10.1155/2011/867525 |
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