Comparison of thromboelastographic profiles and clinical characteristics in children with severe Mycoplasma pneumoniae pneumonia
BackgroundThis study aimed to compare Thromboelastographic (TEG) profiles and clinical characteristics between severe Mycoplasma pneumoniae (MP) pneumonia patients with normal and abnormal TEG parameters.MethodsThe clinical data of 133 children with severe MP pneumonia were retrospectively analyzed....
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1459455/full |
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| author | Yong-tao Li Yu-mei Ma Fu-li Dai Zhen Peng Ya-ping Dai Ke Zhi Hai-hong Feng Shu-jun Li |
| author_facet | Yong-tao Li Yu-mei Ma Fu-li Dai Zhen Peng Ya-ping Dai Ke Zhi Hai-hong Feng Shu-jun Li |
| author_sort | Yong-tao Li |
| collection | DOAJ |
| description | BackgroundThis study aimed to compare Thromboelastographic (TEG) profiles and clinical characteristics between severe Mycoplasma pneumoniae (MP) pneumonia patients with normal and abnormal TEG parameters.MethodsThe clinical data of 133 children with severe MP pneumonia were retrospectively analyzed. Patients were divided into normal (n = 76) and abnormal (n = 57) TEG groups. Demographic characteristics, clinical manifestations, laboratory findings, imaging features, bronchoscopy results, treatment, complications, and outcomes were compared between groups.ResultsThe abnormal TEG group (42.9%) had longer fever duration (median: 8.5 vs. 7.0 days, P < 0.001) and hospital stay (median: 11.5 vs. 10.0 days, P = 0.003). They also showed higher levels of C-reactive protein (median: 30.2 vs. 20.1 mg/L, P < 0.001), lactate dehydrogenase (median: 334.5 vs. 276.0 U/L, P = 0.001), and D-dimer (median: 1.2 vs. 0.5 μg/ml, P < 0.001). HRCT revealed more lobar consolidation or multilobar involvement (36.8% vs. 18.4%, P = 0.016), and bronchoscopy showed more mucous plug obstruction (28.1% vs. 10.5%, P = 0.008) in the abnormal TEG group. TEG parameters indicated a hypercoagulable state with shorter R time (P < 0.001), shorter K time (P < 0.001), and higher MA (P = 0.003). The abnormal TEG group had higher incidences of coagulopathy (P < 0.001), cardiac involvement (elevated cardiac enzymes: 36.8% vs. 17.1%, P = 0.009; pericardial effusion: 10.5% vs. 1.3%, P = 0.017), and plastic bronchitis (P = 0.006). They also required longer azithromycin courses (median: 15 vs. 14 days, P = 0.026).ConclusionChildren with severe MP pneumonia and abnormal TEG profiles have more severe clinical manifestations, higher inflammatory markers, more extensive lung involvement, and a higher incidence of complications. TEG may help identify high-risk patients and guide management in severe MP pneumonia. |
| format | Article |
| id | doaj-art-3636a10bf02e4a259ded2b0a5ef52ae1 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pediatrics |
| spelling | doaj-art-3636a10bf02e4a259ded2b0a5ef52ae12025-01-22T07:11:23ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011310.3389/fped.2025.14594551459455Comparison of thromboelastographic profiles and clinical characteristics in children with severe Mycoplasma pneumoniae pneumoniaYong-tao Li0Yu-mei Ma1Fu-li Dai2Zhen Peng3Ya-ping Dai4Ke Zhi5Hai-hong Feng6Shu-jun Li7Department of Pediatrics, Luoyang Maternal and Child Health Hospital, Luoyang, Henan, ChinaDepartment of Pediatrics, Luoyang Maternal and Child Health Hospital, Luoyang, Henan, ChinaDepartment of Pediatrics, Luoyang Maternal and Child Health Hospital, Luoyang, Henan, ChinaDepartment of Pediatrics, Luoyang Maternal and Child Health Hospital, Luoyang, Henan, ChinaDepartment of Pediatrics, Luoyang Maternal and Child Health Hospital, Luoyang, Henan, ChinaDepartment of Pediatrics, Luoyang Maternal and Child Health Hospital, Luoyang, Henan, ChinaDepartment of Pediatrics, Luoyang Maternal and Child Health Hospital, Luoyang, Henan, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, ChinaBackgroundThis study aimed to compare Thromboelastographic (TEG) profiles and clinical characteristics between severe Mycoplasma pneumoniae (MP) pneumonia patients with normal and abnormal TEG parameters.MethodsThe clinical data of 133 children with severe MP pneumonia were retrospectively analyzed. Patients were divided into normal (n = 76) and abnormal (n = 57) TEG groups. Demographic characteristics, clinical manifestations, laboratory findings, imaging features, bronchoscopy results, treatment, complications, and outcomes were compared between groups.ResultsThe abnormal TEG group (42.9%) had longer fever duration (median: 8.5 vs. 7.0 days, P < 0.001) and hospital stay (median: 11.5 vs. 10.0 days, P = 0.003). They also showed higher levels of C-reactive protein (median: 30.2 vs. 20.1 mg/L, P < 0.001), lactate dehydrogenase (median: 334.5 vs. 276.0 U/L, P = 0.001), and D-dimer (median: 1.2 vs. 0.5 μg/ml, P < 0.001). HRCT revealed more lobar consolidation or multilobar involvement (36.8% vs. 18.4%, P = 0.016), and bronchoscopy showed more mucous plug obstruction (28.1% vs. 10.5%, P = 0.008) in the abnormal TEG group. TEG parameters indicated a hypercoagulable state with shorter R time (P < 0.001), shorter K time (P < 0.001), and higher MA (P = 0.003). The abnormal TEG group had higher incidences of coagulopathy (P < 0.001), cardiac involvement (elevated cardiac enzymes: 36.8% vs. 17.1%, P = 0.009; pericardial effusion: 10.5% vs. 1.3%, P = 0.017), and plastic bronchitis (P = 0.006). They also required longer azithromycin courses (median: 15 vs. 14 days, P = 0.026).ConclusionChildren with severe MP pneumonia and abnormal TEG profiles have more severe clinical manifestations, higher inflammatory markers, more extensive lung involvement, and a higher incidence of complications. TEG may help identify high-risk patients and guide management in severe MP pneumonia.https://www.frontiersin.org/articles/10.3389/fped.2025.1459455/fullthromboelastographic profilesclinical characteristicsmycoplasma pneumoniae pneumoniaseverechildren |
| spellingShingle | Yong-tao Li Yu-mei Ma Fu-li Dai Zhen Peng Ya-ping Dai Ke Zhi Hai-hong Feng Shu-jun Li Comparison of thromboelastographic profiles and clinical characteristics in children with severe Mycoplasma pneumoniae pneumonia Frontiers in Pediatrics thromboelastographic profiles clinical characteristics mycoplasma pneumoniae pneumonia severe children |
| title | Comparison of thromboelastographic profiles and clinical characteristics in children with severe Mycoplasma pneumoniae pneumonia |
| title_full | Comparison of thromboelastographic profiles and clinical characteristics in children with severe Mycoplasma pneumoniae pneumonia |
| title_fullStr | Comparison of thromboelastographic profiles and clinical characteristics in children with severe Mycoplasma pneumoniae pneumonia |
| title_full_unstemmed | Comparison of thromboelastographic profiles and clinical characteristics in children with severe Mycoplasma pneumoniae pneumonia |
| title_short | Comparison of thromboelastographic profiles and clinical characteristics in children with severe Mycoplasma pneumoniae pneumonia |
| title_sort | comparison of thromboelastographic profiles and clinical characteristics in children with severe mycoplasma pneumoniae pneumonia |
| topic | thromboelastographic profiles clinical characteristics mycoplasma pneumoniae pneumonia severe children |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1459455/full |
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