Microradiography of Microcalcifications in Breast Specimen: A New Histological Correlation Procedure and the Effect of Improved Resolution on Diagnostic Validity
Introduction. Does high-resolution visualization of microcalcifications improve diagnostic reliability? Method. X-rays were taken of mamma specimens with microcalcifications in 32 patients (10 malignant; 22 benign) using conventional radiography (12 Lp/mm) and high-resolution radiography (2000 Lp/m...
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2012-01-01
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| Series: | Radiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/526293 |
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| author | H.-J. Langen S. Koehler J. Bielmeier R. Jocher D. Kranzfelder N. Jagusch G. Treutlein Th. Wetzler J. Müller G. Ott |
| author_facet | H.-J. Langen S. Koehler J. Bielmeier R. Jocher D. Kranzfelder N. Jagusch G. Treutlein Th. Wetzler J. Müller G. Ott |
| author_sort | H.-J. Langen |
| collection | DOAJ |
| description | Introduction. Does high-resolution visualization of microcalcifications improve diagnostic reliability? Method. X-rays were taken of mamma specimens with microcalcifications in 32 patients (10 malignant; 22 benign) using conventional radiography (12 Lp/mm) and high-resolution radiography (2000 Lp/mm). Histological sections were subsequently prepared and correlated to the microradiographic image and every calcification was assigned an exact malignant or benign histological diagnosis. Five radiologists classified single groups of calcifications in both methods according to the BIRADS classification system. Results. Using microradiography microcalcifications can be shown in high resolution at the cell level including histological correlation. In some cases, the diagnostic validity was improved by the high resolution in microradiography. In other cases, the high resolution resulted in more visible calcifications, thus giving benign calcifications a malignant appearance. In the BIRADS 2 and 3 group, the probability of malignancy was 28.6% in the conventional radiography evaluation and 37.8% in the microradiography evaluation. In the BIRADS 4 and 5 group, the probability of malignancy was 34.2% in the conventional radiography evaluation and 24.4% in the microradiography evaluation. The differences were not significant. Summary. Overall, the improved resolution in microradiography did not show an improvement in diagnostic accuracy compared to conventional radiography. |
| format | Article |
| id | doaj-art-3635d92631b9462d9e5a2c485bd2920d |
| institution | Kabale University |
| issn | 2090-1941 2090-195X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Radiology Research and Practice |
| spelling | doaj-art-3635d92631b9462d9e5a2c485bd2920d2025-02-03T05:44:59ZengWileyRadiology Research and Practice2090-19412090-195X2012-01-01201210.1155/2012/526293526293Microradiography of Microcalcifications in Breast Specimen: A New Histological Correlation Procedure and the Effect of Improved Resolution on Diagnostic ValidityH.-J. Langen0S. Koehler1J. Bielmeier2R. Jocher3D. Kranzfelder4N. Jagusch5G. Treutlein6Th. Wetzler7J. Müller8G. Ott9Department of Radiology, The Medical Mission Clinic, Salvatorstraβe 7, 97074 Wuerzburg, GermanyDepartment of Radiology, The Medical Mission Clinic, Salvatorstraβe 7, 97074 Wuerzburg, GermanyDepartment of Radiology, The Medical Mission Clinic, Salvatorstraβe 7, 97074 Wuerzburg, GermanyDepartment of Radiology, The Medical Mission Clinic, Salvatorstraβe 7, 97074 Wuerzburg, GermanyDepartment of Gynecology, The Medical Mission Clinic, Salvatorstraβe 7, 97074 Wuerzburg, GermanyDepartment of Radiology, The Medical Mission Clinic, Salvatorstraβe 7, 97074 Wuerzburg, GermanyPrivate Practice, Center for Radiological Diagnostics, Eichhornstraβe 21, 97070 Wuerzburg, GermanyPrivate Practice, Center for Radiological Diagnostics, Eichhornstraβe 21, 97070 Wuerzburg, GermanyDepartment of Pathology, the University of Wuerzburg, 97080 Wuerzburg, GermanyDepartment of Pathology, the University of Wuerzburg, 97080 Wuerzburg, GermanyIntroduction. Does high-resolution visualization of microcalcifications improve diagnostic reliability? Method. X-rays were taken of mamma specimens with microcalcifications in 32 patients (10 malignant; 22 benign) using conventional radiography (12 Lp/mm) and high-resolution radiography (2000 Lp/mm). Histological sections were subsequently prepared and correlated to the microradiographic image and every calcification was assigned an exact malignant or benign histological diagnosis. Five radiologists classified single groups of calcifications in both methods according to the BIRADS classification system. Results. Using microradiography microcalcifications can be shown in high resolution at the cell level including histological correlation. In some cases, the diagnostic validity was improved by the high resolution in microradiography. In other cases, the high resolution resulted in more visible calcifications, thus giving benign calcifications a malignant appearance. In the BIRADS 2 and 3 group, the probability of malignancy was 28.6% in the conventional radiography evaluation and 37.8% in the microradiography evaluation. In the BIRADS 4 and 5 group, the probability of malignancy was 34.2% in the conventional radiography evaluation and 24.4% in the microradiography evaluation. The differences were not significant. Summary. Overall, the improved resolution in microradiography did not show an improvement in diagnostic accuracy compared to conventional radiography.http://dx.doi.org/10.1155/2012/526293 |
| spellingShingle | H.-J. Langen S. Koehler J. Bielmeier R. Jocher D. Kranzfelder N. Jagusch G. Treutlein Th. Wetzler J. Müller G. Ott Microradiography of Microcalcifications in Breast Specimen: A New Histological Correlation Procedure and the Effect of Improved Resolution on Diagnostic Validity Radiology Research and Practice |
| title | Microradiography of Microcalcifications in Breast Specimen: A New Histological Correlation Procedure and the Effect of Improved Resolution on Diagnostic Validity |
| title_full | Microradiography of Microcalcifications in Breast Specimen: A New Histological Correlation Procedure and the Effect of Improved Resolution on Diagnostic Validity |
| title_fullStr | Microradiography of Microcalcifications in Breast Specimen: A New Histological Correlation Procedure and the Effect of Improved Resolution on Diagnostic Validity |
| title_full_unstemmed | Microradiography of Microcalcifications in Breast Specimen: A New Histological Correlation Procedure and the Effect of Improved Resolution on Diagnostic Validity |
| title_short | Microradiography of Microcalcifications in Breast Specimen: A New Histological Correlation Procedure and the Effect of Improved Resolution on Diagnostic Validity |
| title_sort | microradiography of microcalcifications in breast specimen a new histological correlation procedure and the effect of improved resolution on diagnostic validity |
| url | http://dx.doi.org/10.1155/2012/526293 |
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