Inflammatory Response and Immune Regulation in Brain-Heart Interaction after Stroke
Cerebrocardiac syndrome (CCS) is one of the secondary myocardial injuries after stroke. Cerebrocardiac syndrome may result in a poor prognosis with high mortality. Understanding the mechanism of the brain-heart interaction may be crucial for clinical treatment of pathological changes in CCS. Accumul...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2022/2406122 |
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| _version_ | 1832552490141220864 |
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| author | Lihua Zou Ruquan Han |
| author_facet | Lihua Zou Ruquan Han |
| author_sort | Lihua Zou |
| collection | DOAJ |
| description | Cerebrocardiac syndrome (CCS) is one of the secondary myocardial injuries after stroke. Cerebrocardiac syndrome may result in a poor prognosis with high mortality. Understanding the mechanism of the brain-heart interaction may be crucial for clinical treatment of pathological changes in CCS. Accumulating evidence suggests that the inflammatory response is involved in the brain-heart interaction after stroke. Systemic inflammatory response syndrome (SIRS) evoked by stroke may injure myocardial cells directly, in which the interplay between inflammatory response, oxidative stress, cardiac sympathetic/parasympathetic dysfunction, and splenic immunoregulation may be also the key pathophysiology factor. This review article summarizes the current understanding of inflammatory response and immune regulation in brain-heart interaction after stroke. |
| format | Article |
| id | doaj-art-363504bb0e0c4fda87a96402e210f8ae |
| institution | Kabale University |
| issn | 1755-5922 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-363504bb0e0c4fda87a96402e210f8ae2025-02-03T05:58:31ZengWileyCardiovascular Therapeutics1755-59222022-01-01202210.1155/2022/2406122Inflammatory Response and Immune Regulation in Brain-Heart Interaction after StrokeLihua Zou0Ruquan Han1Department of AnesthesiologyDepartment of AnesthesiologyCerebrocardiac syndrome (CCS) is one of the secondary myocardial injuries after stroke. Cerebrocardiac syndrome may result in a poor prognosis with high mortality. Understanding the mechanism of the brain-heart interaction may be crucial for clinical treatment of pathological changes in CCS. Accumulating evidence suggests that the inflammatory response is involved in the brain-heart interaction after stroke. Systemic inflammatory response syndrome (SIRS) evoked by stroke may injure myocardial cells directly, in which the interplay between inflammatory response, oxidative stress, cardiac sympathetic/parasympathetic dysfunction, and splenic immunoregulation may be also the key pathophysiology factor. This review article summarizes the current understanding of inflammatory response and immune regulation in brain-heart interaction after stroke.http://dx.doi.org/10.1155/2022/2406122 |
| spellingShingle | Lihua Zou Ruquan Han Inflammatory Response and Immune Regulation in Brain-Heart Interaction after Stroke Cardiovascular Therapeutics |
| title | Inflammatory Response and Immune Regulation in Brain-Heart Interaction after Stroke |
| title_full | Inflammatory Response and Immune Regulation in Brain-Heart Interaction after Stroke |
| title_fullStr | Inflammatory Response and Immune Regulation in Brain-Heart Interaction after Stroke |
| title_full_unstemmed | Inflammatory Response and Immune Regulation in Brain-Heart Interaction after Stroke |
| title_short | Inflammatory Response and Immune Regulation in Brain-Heart Interaction after Stroke |
| title_sort | inflammatory response and immune regulation in brain heart interaction after stroke |
| url | http://dx.doi.org/10.1155/2022/2406122 |
| work_keys_str_mv | AT lihuazou inflammatoryresponseandimmuneregulationinbrainheartinteractionafterstroke AT ruquanhan inflammatoryresponseandimmuneregulationinbrainheartinteractionafterstroke |