MicroRNAs in Neurotoxicity
MicroRNAs are gaining importance as regulators of gene expression with the capability to fine-tune and modulate cellular events. The complex network with their selective targets (mRNAs/genes) pave way for regulation of many physiological processes. Dysregulation of normal neuronal activities could r...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2012/870150 |
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| _version_ | 1832562459301380096 |
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| author | Prameet Kaur Arunmozhiarasi Armugam Kandiah Jeyaseelan |
| author_facet | Prameet Kaur Arunmozhiarasi Armugam Kandiah Jeyaseelan |
| author_sort | Prameet Kaur |
| collection | DOAJ |
| description | MicroRNAs are gaining importance as regulators of gene expression with the capability to fine-tune and modulate cellular events. The complex network with their selective targets (mRNAs/genes) pave way for regulation of many physiological processes. Dysregulation of normal neuronal activities could result in accumulation of substances that are detrimental to neuronal functions and subsequently result in neurotoxicity. Neurotoxicity-mediated pathophysiological conditions could then manifest as diseases or disabilities like Parkinson’s and Alzheimer’s which have debilitating implications. Such toxicity can be a result of individuals predisposed due to genetic inheritance or from other sources such as brain tumours. Neurotoxicity can also be brought about by external agents like drugs and alcohol as well as brain injury with miRNAs playing a pivotal role in diseases. It is therefore vital to understand the expression of these microRNAs and their impact on neuronal activities. In this paper, we discuss some of the neuronal pathophysiological conditions that could be caused by dysregulated microRNAs. |
| format | Article |
| id | doaj-art-3631643bab3543918f1ea5c9477d0a6b |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-3631643bab3543918f1ea5c9477d0a6b2025-02-03T01:22:35ZengWileyJournal of Toxicology1687-81911687-82052012-01-01201210.1155/2012/870150870150MicroRNAs in NeurotoxicityPrameet Kaur0Arunmozhiarasi Armugam1Kandiah Jeyaseelan2Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, 117597, SingaporeDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, 117597, SingaporeDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 8 Medical Drive, 117597, SingaporeMicroRNAs are gaining importance as regulators of gene expression with the capability to fine-tune and modulate cellular events. The complex network with their selective targets (mRNAs/genes) pave way for regulation of many physiological processes. Dysregulation of normal neuronal activities could result in accumulation of substances that are detrimental to neuronal functions and subsequently result in neurotoxicity. Neurotoxicity-mediated pathophysiological conditions could then manifest as diseases or disabilities like Parkinson’s and Alzheimer’s which have debilitating implications. Such toxicity can be a result of individuals predisposed due to genetic inheritance or from other sources such as brain tumours. Neurotoxicity can also be brought about by external agents like drugs and alcohol as well as brain injury with miRNAs playing a pivotal role in diseases. It is therefore vital to understand the expression of these microRNAs and their impact on neuronal activities. In this paper, we discuss some of the neuronal pathophysiological conditions that could be caused by dysregulated microRNAs.http://dx.doi.org/10.1155/2012/870150 |
| spellingShingle | Prameet Kaur Arunmozhiarasi Armugam Kandiah Jeyaseelan MicroRNAs in Neurotoxicity Journal of Toxicology |
| title | MicroRNAs in Neurotoxicity |
| title_full | MicroRNAs in Neurotoxicity |
| title_fullStr | MicroRNAs in Neurotoxicity |
| title_full_unstemmed | MicroRNAs in Neurotoxicity |
| title_short | MicroRNAs in Neurotoxicity |
| title_sort | micrornas in neurotoxicity |
| url | http://dx.doi.org/10.1155/2012/870150 |
| work_keys_str_mv | AT prameetkaur micrornasinneurotoxicity AT arunmozhiarasiarmugam micrornasinneurotoxicity AT kandiahjeyaseelan micrornasinneurotoxicity |