Significance of autoantibodies in diagnostics of systemic vasculitis
Systemic vasculitis is a heterogeneous group of disorders characterized by inflammation and necrosis in the vessel wall. Patients usually present a quite broad spectrum of manifestations which vary in terms of vessels’ size affected, organs involvement, and the extent of inflammatory process as well...
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Open Exploration Publishing Inc.
2023-07-01
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| Series: | Exploration of Musculoskeletal Diseases |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100712/100712.pdf |
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| author | Katarzyna Fischer Marek Brzosko |
| author_facet | Katarzyna Fischer Marek Brzosko |
| author_sort | Katarzyna Fischer |
| collection | DOAJ |
| description | Systemic vasculitis is a heterogeneous group of disorders characterized by inflammation and necrosis in the vessel wall. Patients usually present a quite broad spectrum of manifestations which vary in terms of vessels’ size affected, organs involvement, and the extent of inflammatory process as well as an immunological diversity, including autoantibodies profile. Though, the diagnosis is based on clinical features, tissue biopsy, imaging investigations, and serologic tests. The main autoantibodies, important not only in the diagnosis but also in monitoring and prognosis of systemic vasculitides, are anti-neutrophil cytoplasmic antibodies (ANCA), anti-glomerular basement membrane antibodies (anti-GBM), anti-complement component C1q antibodies (anti-C1q), and cryoglobulins. Although other autoantibodies have been analyzed, their clinical utility still needs further investigation. The current work aimed to review the clinical associations of main autoantibodies in systemic vasculitis. |
| format | Article |
| id | doaj-art-361efc8d4e734a41b4b2aa80b8ea09ad |
| institution | DOAJ |
| issn | 2836-6468 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Musculoskeletal Diseases |
| spelling | doaj-art-361efc8d4e734a41b4b2aa80b8ea09ad2025-08-20T02:44:56ZengOpen Exploration Publishing Inc.Exploration of Musculoskeletal Diseases2836-64682023-07-0114778310.37349/emd.2023.00012Significance of autoantibodies in diagnostics of systemic vasculitisKatarzyna Fischer0https://orcid.org/0000-0003-4792-2099Marek Brzosko1https://orcid.org/0000-0001-7681-4367Independent Laboratory for Rheumatologic Diagnostics, Pomeranian Medical University in Szczecin, 71-252 Szczecin, PolandDepartment of Rheumatology, Internal Medicine, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin, 71-252 Szczecin, PolandSystemic vasculitis is a heterogeneous group of disorders characterized by inflammation and necrosis in the vessel wall. Patients usually present a quite broad spectrum of manifestations which vary in terms of vessels’ size affected, organs involvement, and the extent of inflammatory process as well as an immunological diversity, including autoantibodies profile. Though, the diagnosis is based on clinical features, tissue biopsy, imaging investigations, and serologic tests. The main autoantibodies, important not only in the diagnosis but also in monitoring and prognosis of systemic vasculitides, are anti-neutrophil cytoplasmic antibodies (ANCA), anti-glomerular basement membrane antibodies (anti-GBM), anti-complement component C1q antibodies (anti-C1q), and cryoglobulins. Although other autoantibodies have been analyzed, their clinical utility still needs further investigation. The current work aimed to review the clinical associations of main autoantibodies in systemic vasculitis.https://www.explorationpub.com/uploads/Article/A100712/100712.pdfsystemic vasculitisanti-neutrophil cytoplasmic antibodiesanti-glomerular basement membrane antibodiesanti-complement component c1q antibodiescryoglobulins |
| spellingShingle | Katarzyna Fischer Marek Brzosko Significance of autoantibodies in diagnostics of systemic vasculitis Exploration of Musculoskeletal Diseases systemic vasculitis anti-neutrophil cytoplasmic antibodies anti-glomerular basement membrane antibodies anti-complement component c1q antibodies cryoglobulins |
| title | Significance of autoantibodies in diagnostics of systemic vasculitis |
| title_full | Significance of autoantibodies in diagnostics of systemic vasculitis |
| title_fullStr | Significance of autoantibodies in diagnostics of systemic vasculitis |
| title_full_unstemmed | Significance of autoantibodies in diagnostics of systemic vasculitis |
| title_short | Significance of autoantibodies in diagnostics of systemic vasculitis |
| title_sort | significance of autoantibodies in diagnostics of systemic vasculitis |
| topic | systemic vasculitis anti-neutrophil cytoplasmic antibodies anti-glomerular basement membrane antibodies anti-complement component c1q antibodies cryoglobulins |
| url | https://www.explorationpub.com/uploads/Article/A100712/100712.pdf |
| work_keys_str_mv | AT katarzynafischer significanceofautoantibodiesindiagnosticsofsystemicvasculitis AT marekbrzosko significanceofautoantibodiesindiagnosticsofsystemicvasculitis |