The Brain’s Aging Resting State Functional Connectivity
Resting state networks (RSNs) of the brain are characterized as correlated spontaneous time-varying fluctuations in the absence of goal-directed tasks. These networks can be local or large-scale spanning the brain. The study of the spatiotemporal properties of such networks has helped understand the...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-01-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://www.imrpress.com/journal/JIN/24/1/10.31083/JIN25041 |
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| author | Ali F. Khan Nada Saleh Zachary A. Smith |
| author_facet | Ali F. Khan Nada Saleh Zachary A. Smith |
| author_sort | Ali F. Khan |
| collection | DOAJ |
| description | Resting state networks (RSNs) of the brain are characterized as correlated spontaneous time-varying fluctuations in the absence of goal-directed tasks. These networks can be local or large-scale spanning the brain. The study of the spatiotemporal properties of such networks has helped understand the brain’s fundamental functional organization under healthy and diseased states. As we age, these spatiotemporal properties change. Moreover, RSNs exhibit neural plasticity to compensate for the loss of cognitive functions. This narrative review aims to summarize current knowledge from functional magnetic resonance imaging (fMRI) studies on age-related alterations in RSNs. Underlying mechanisms influencing such changes are discussed. Methodological challenges and future directions are also addressed. By providing an overview of the current state of knowledge in this field, this review aims to guide future research endeavors aimed at promoting healthy brain aging and developing effective interventions for age-related cognitive impairment and neurodegenerative diseases. |
| format | Article |
| id | doaj-art-360722f9d3f648a1a229321b61f6d834 |
| institution | Kabale University |
| issn | 0219-6352 1757-448X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj-art-360722f9d3f648a1a229321b61f6d8342025-01-25T07:38:07ZengIMR PressJournal of Integrative Neuroscience0219-63521757-448X2025-01-012412504110.31083/JIN25041S0219-6352(24)00826-XThe Brain’s Aging Resting State Functional ConnectivityAli F. Khan0Nada Saleh1Zachary A. Smith2Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAGraduate College, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAResting state networks (RSNs) of the brain are characterized as correlated spontaneous time-varying fluctuations in the absence of goal-directed tasks. These networks can be local or large-scale spanning the brain. The study of the spatiotemporal properties of such networks has helped understand the brain’s fundamental functional organization under healthy and diseased states. As we age, these spatiotemporal properties change. Moreover, RSNs exhibit neural plasticity to compensate for the loss of cognitive functions. This narrative review aims to summarize current knowledge from functional magnetic resonance imaging (fMRI) studies on age-related alterations in RSNs. Underlying mechanisms influencing such changes are discussed. Methodological challenges and future directions are also addressed. By providing an overview of the current state of knowledge in this field, this review aims to guide future research endeavors aimed at promoting healthy brain aging and developing effective interventions for age-related cognitive impairment and neurodegenerative diseases.https://www.imrpress.com/journal/JIN/24/1/10.31083/JIN25041agingresting state networksfunctional connectivityneuroplasticitycortical reservefmri |
| spellingShingle | Ali F. Khan Nada Saleh Zachary A. Smith The Brain’s Aging Resting State Functional Connectivity Journal of Integrative Neuroscience aging resting state networks functional connectivity neuroplasticity cortical reserve fmri |
| title | The Brain’s Aging Resting State Functional Connectivity |
| title_full | The Brain’s Aging Resting State Functional Connectivity |
| title_fullStr | The Brain’s Aging Resting State Functional Connectivity |
| title_full_unstemmed | The Brain’s Aging Resting State Functional Connectivity |
| title_short | The Brain’s Aging Resting State Functional Connectivity |
| title_sort | brain s aging resting state functional connectivity |
| topic | aging resting state networks functional connectivity neuroplasticity cortical reserve fmri |
| url | https://www.imrpress.com/journal/JIN/24/1/10.31083/JIN25041 |
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