The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer

Background: Fatigue is a prevalent and complex condition with significant impacts on well-being. Existing fatigue assessments often lack comprehensiveness or practicality for general population studies. Methods: This study validated the REST Questionnaire, a novel fatigue assessment tool, in a sampl...

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Main Authors: Giuseppe Di Lorenzo, Carlo Buonerba, Raffaele Baio, Eleonora Monteleone, Francesco Passaro, Antonio Tufano, Vittorino Montanaro, Vittorio Riccio, Ilaria Gallo, Francesca Cappuccio, Federica Fortino, Anna Buonocore, Federica Monaco, Antonio Verde, Anna Rita Amato, Oriana Strianese, Ferdinando Costabile, Luca Scafuri
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Diseases
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Online Access:https://www.mdpi.com/2079-9721/13/1/15
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author Giuseppe Di Lorenzo
Carlo Buonerba
Raffaele Baio
Eleonora Monteleone
Francesco Passaro
Antonio Tufano
Vittorino Montanaro
Vittorio Riccio
Ilaria Gallo
Francesca Cappuccio
Federica Fortino
Anna Buonocore
Federica Monaco
Antonio Verde
Anna Rita Amato
Oriana Strianese
Ferdinando Costabile
Luca Scafuri
author_facet Giuseppe Di Lorenzo
Carlo Buonerba
Raffaele Baio
Eleonora Monteleone
Francesco Passaro
Antonio Tufano
Vittorino Montanaro
Vittorio Riccio
Ilaria Gallo
Francesca Cappuccio
Federica Fortino
Anna Buonocore
Federica Monaco
Antonio Verde
Anna Rita Amato
Oriana Strianese
Ferdinando Costabile
Luca Scafuri
author_sort Giuseppe Di Lorenzo
collection DOAJ
description Background: Fatigue is a prevalent and complex condition with significant impacts on well-being. Existing fatigue assessments often lack comprehensiveness or practicality for general population studies. Methods: This study validated the REST Questionnaire, a novel fatigue assessment tool, in a sample of 268 adults. Psychometric properties, including internal consistency and construct validity, were evaluated. REST scores were correlated with WHO-5 well-being, BMI, self-rated health, and chronic conditions. Exploratory factor analysis identified underlying dimensions of fatigue. Results: The REST Questionnaire demonstrated excellent internal consistency (Cronbach’s alpha = 0.918) and construct validity. Higher fatigue scores were associated with lower well-being, female gender, and the presence of certain chronic conditions (cancer, kidney stones, gastric ulcers). Two distinct fatigue dimensions, “physical fatigue and functional impacts” and “emotional and social consequences”, were identified. Conclusions: The REST Questionnaire is a reliable and valid tool for assessing fatigue in the general population. Its multidimensional framework and sensitivity to comorbidities offer valuable insights for research and public health applications, with the potential to inform targeted interventions aimed at improving well-being.
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spelling doaj-art-35fa6b3d2ff744f38aca3486b3e4e4b82025-01-24T13:29:15ZengMDPI AGDiseases2079-97212025-01-011311510.3390/diseases13010015The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of CancerGiuseppe Di Lorenzo0Carlo Buonerba1Raffaele Baio2Eleonora Monteleone3Francesco Passaro4Antonio Tufano5Vittorino Montanaro6Vittorio Riccio7Ilaria Gallo8Francesca Cappuccio9Federica Fortino10Anna Buonocore11Federica Monaco12Antonio Verde13Anna Rita Amato14Oriana Strianese15Ferdinando Costabile16Luca Scafuri17Oncology Unit, “Andrea Tortora” Hospital, ASL Salerno, 84016 Pagani, ItalyOncology Unit, “Andrea Tortora” Hospital, ASL Salerno, 84016 Pagani, ItalyDepartment of Urology, Umberto I, Nocera Inferiore, 84014 Salerno, ItalyDepartment of Urology, Istituito Nazionale Tumori IRCCS Fondazione G. Pascale, 80131 Napoli, ItalyDepartment of Urology, Istituito Nazionale Tumori IRCCS Fondazione G. Pascale, 80131 Napoli, ItalyDepartment of Urology, Istituito Nazionale Tumori IRCCS Fondazione G. Pascale, 80131 Napoli, ItalyUrology Unit, San Leonardo Hospital, Castellammare Di Stabia, 80053 Naples, ItalyOspedale S. Maria della Pietà, 80026 Casoria, ItalyPrimary Care Department, ASL Salerno (SA), 84016 Pagani, ItalyOncology Unit, “Andrea Tortora” Hospital, ASL Salerno, 84016 Pagani, ItalyOncology Unit, “Andrea Tortora” Hospital, ASL Salerno, 84016 Pagani, ItalyPrimary Care Department, ASL Salerno (SA), 84016 Pagani, ItalyDepartment of Anesthesia, San Paolo Hospital ASL Napoli 1 Centro, 80125 Naples, ItalyOncology Unit, “Andrea Tortora” Hospital, ASL Salerno, 84016 Pagani, ItalyOncology Unit, “Andrea Tortora” Hospital, ASL Salerno, 84016 Pagani, ItalyOncology Unit, “Andrea Tortora” Hospital, ASL Salerno, 84016 Pagani, ItalyOncology Unit, “Andrea Tortora” Hospital, ASL Salerno, 84016 Pagani, ItalyOncology Unit, “Andrea Tortora” Hospital, ASL Salerno, 84016 Pagani, ItalyBackground: Fatigue is a prevalent and complex condition with significant impacts on well-being. Existing fatigue assessments often lack comprehensiveness or practicality for general population studies. Methods: This study validated the REST Questionnaire, a novel fatigue assessment tool, in a sample of 268 adults. Psychometric properties, including internal consistency and construct validity, were evaluated. REST scores were correlated with WHO-5 well-being, BMI, self-rated health, and chronic conditions. Exploratory factor analysis identified underlying dimensions of fatigue. Results: The REST Questionnaire demonstrated excellent internal consistency (Cronbach’s alpha = 0.918) and construct validity. Higher fatigue scores were associated with lower well-being, female gender, and the presence of certain chronic conditions (cancer, kidney stones, gastric ulcers). Two distinct fatigue dimensions, “physical fatigue and functional impacts” and “emotional and social consequences”, were identified. Conclusions: The REST Questionnaire is a reliable and valid tool for assessing fatigue in the general population. Its multidimensional framework and sensitivity to comorbidities offer valuable insights for research and public health applications, with the potential to inform targeted interventions aimed at improving well-being.https://www.mdpi.com/2079-9721/13/1/15fatigue assessmentREST questionnairepsychometricsvalidation studypublic healthwell-being
spellingShingle Giuseppe Di Lorenzo
Carlo Buonerba
Raffaele Baio
Eleonora Monteleone
Francesco Passaro
Antonio Tufano
Vittorino Montanaro
Vittorio Riccio
Ilaria Gallo
Francesca Cappuccio
Federica Fortino
Anna Buonocore
Federica Monaco
Antonio Verde
Anna Rita Amato
Oriana Strianese
Ferdinando Costabile
Luca Scafuri
The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer
Diseases
fatigue assessment
REST questionnaire
psychometrics
validation study
public health
well-being
title The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer
title_full The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer
title_fullStr The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer
title_full_unstemmed The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer
title_short The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer
title_sort development and initial validation of the rest questionnaire a multidimensional tool for assessing fatigue in individuals with and without a history of cancer
topic fatigue assessment
REST questionnaire
psychometrics
validation study
public health
well-being
url https://www.mdpi.com/2079-9721/13/1/15
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