Shorter telomere length in COPD cases secondary to biomass-burning smoke exposure
Abstract Background Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow obstruction and destruction of lung tissue, primarily attributed to tobacco smoking. However, other factors like biomass-burning smoke (BS) exposure are also implicated. COPD has been described a...
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BMC
2025-01-01
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| Series: | Respiratory Research |
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| Online Access: | https://doi.org/10.1186/s12931-024-03074-9 |
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| author | Angélica Domínguez-de-Barros Gloria Pérez-Rubio Ingrid Fricke-Galindo Alejandra Ramírez-Venegas Malena Gajate-Arenas Rafael Hernández-Zenteno Salvador García-Carmona Robinson Robles-Hernández María E. Ramírez-Díaz Filiberto Cruz-Vicente María L. Martínez-Gómez Jacob Lorenzo-Morales Ramcés Falfán-Valencia Elizabeth Córdoba-Lanús |
| author_facet | Angélica Domínguez-de-Barros Gloria Pérez-Rubio Ingrid Fricke-Galindo Alejandra Ramírez-Venegas Malena Gajate-Arenas Rafael Hernández-Zenteno Salvador García-Carmona Robinson Robles-Hernández María E. Ramírez-Díaz Filiberto Cruz-Vicente María L. Martínez-Gómez Jacob Lorenzo-Morales Ramcés Falfán-Valencia Elizabeth Córdoba-Lanús |
| author_sort | Angélica Domínguez-de-Barros |
| collection | DOAJ |
| description | Abstract Background Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow obstruction and destruction of lung tissue, primarily attributed to tobacco smoking. However, other factors like biomass-burning smoke (BS) exposure are also implicated. COPD has been described as an accelerated aging disease, and telomere length is a biomarker of aging. Methods This study examined telomere length in 189 Mexican individuals, from which 93 developed COPD secondary to BS exposure (BE-COPD); the rest of the participants were exposed to BS but did not develop the disease. Lung function parameters were measured by spirometry, and relative telomere length (rTL) from peripheral blood DNA was determined using multiplex qPCR. Results Results showed rTL to inversely correlate with age (R2=-0.207, p = 0.006) and with the hours-a-day of BS exposure (R2=-0.297, p < 0.001). Within BE-COPD cases, rTL was associated with daily BS exposure, and BE-COPD individuals exhibited a reduced rTL compared to controls (1.39 ± 0.45 vs. 0.89 ± 0.50; p < 0.001). When compared by rTL length in BE-COPD cases, longer telomeres were associated with decreased COPD risk (β = 0.134, 95% CI = 0.053–0.339; p < 0.001). However, no significant relationship was found between rTL and clinical or lung function parameters in the BE-COPD group. Conclusions This is the first study to document that individuals with COPD secondary to biomass smoke exposure present shorter telomeres than BS-exposed subjects who did not develop the disease. |
| format | Article |
| id | doaj-art-35e187034f3c439a8827b06f71c51ee0 |
| institution | Kabale University |
| issn | 1465-993X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj-art-35e187034f3c439a8827b06f71c51ee02025-01-19T12:36:27ZengBMCRespiratory Research1465-993X2025-01-012611810.1186/s12931-024-03074-9Shorter telomere length in COPD cases secondary to biomass-burning smoke exposureAngélica Domínguez-de-Barros0Gloria Pérez-Rubio1Ingrid Fricke-Galindo2Alejandra Ramírez-Venegas3Malena Gajate-Arenas4Rafael Hernández-Zenteno5Salvador García-Carmona6Robinson Robles-Hernández7María E. Ramírez-Díaz8Filiberto Cruz-Vicente9María L. Martínez-Gómez10Jacob Lorenzo-Morales11Ramcés Falfán-Valencia12Elizabeth Córdoba-Lanús13Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La LagunaHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas (INER)HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas (INER)Departamento de Investigación en Tabaquismo y EPOC, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas (INER)Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La LagunaDepartamento de Investigación en Tabaquismo y EPOC, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas (INER)HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas (INER)Departamento de Investigación en Tabaquismo y EPOC, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas (INER)Coordinación de Vigilancia Epidemiológica, Tlacolula de Matamoros Oaxaca, Servicios de Salud de OaxacaDepartamento de Medicina Interna, Hospital Civil Aurelio Valdivieso, Servicios de Salud de OaxacaHospital Regional de Alta Especialidad de OaxacaInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La LagunaHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas (INER)Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La LagunaAbstract Background Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow obstruction and destruction of lung tissue, primarily attributed to tobacco smoking. However, other factors like biomass-burning smoke (BS) exposure are also implicated. COPD has been described as an accelerated aging disease, and telomere length is a biomarker of aging. Methods This study examined telomere length in 189 Mexican individuals, from which 93 developed COPD secondary to BS exposure (BE-COPD); the rest of the participants were exposed to BS but did not develop the disease. Lung function parameters were measured by spirometry, and relative telomere length (rTL) from peripheral blood DNA was determined using multiplex qPCR. Results Results showed rTL to inversely correlate with age (R2=-0.207, p = 0.006) and with the hours-a-day of BS exposure (R2=-0.297, p < 0.001). Within BE-COPD cases, rTL was associated with daily BS exposure, and BE-COPD individuals exhibited a reduced rTL compared to controls (1.39 ± 0.45 vs. 0.89 ± 0.50; p < 0.001). When compared by rTL length in BE-COPD cases, longer telomeres were associated with decreased COPD risk (β = 0.134, 95% CI = 0.053–0.339; p < 0.001). However, no significant relationship was found between rTL and clinical or lung function parameters in the BE-COPD group. Conclusions This is the first study to document that individuals with COPD secondary to biomass smoke exposure present shorter telomeres than BS-exposed subjects who did not develop the disease.https://doi.org/10.1186/s12931-024-03074-9Biomass smokeCOPDPulmonary functionTelomere length |
| spellingShingle | Angélica Domínguez-de-Barros Gloria Pérez-Rubio Ingrid Fricke-Galindo Alejandra Ramírez-Venegas Malena Gajate-Arenas Rafael Hernández-Zenteno Salvador García-Carmona Robinson Robles-Hernández María E. Ramírez-Díaz Filiberto Cruz-Vicente María L. Martínez-Gómez Jacob Lorenzo-Morales Ramcés Falfán-Valencia Elizabeth Córdoba-Lanús Shorter telomere length in COPD cases secondary to biomass-burning smoke exposure Respiratory Research Biomass smoke COPD Pulmonary function Telomere length |
| title | Shorter telomere length in COPD cases secondary to biomass-burning smoke exposure |
| title_full | Shorter telomere length in COPD cases secondary to biomass-burning smoke exposure |
| title_fullStr | Shorter telomere length in COPD cases secondary to biomass-burning smoke exposure |
| title_full_unstemmed | Shorter telomere length in COPD cases secondary to biomass-burning smoke exposure |
| title_short | Shorter telomere length in COPD cases secondary to biomass-burning smoke exposure |
| title_sort | shorter telomere length in copd cases secondary to biomass burning smoke exposure |
| topic | Biomass smoke COPD Pulmonary function Telomere length |
| url | https://doi.org/10.1186/s12931-024-03074-9 |
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