Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study
Abstract Background Chronic inflammation is increasingly recognized as a crucial contributor to sarcopenia pathogenesis, but accurate diagnosis remains a challenge. Aim Our study aims to investigate the relationship between sarcopenia and the Systemic Immune-Inflammation Index (SII), a comprehensive...
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BMC
2025-01-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-025-05686-2 |
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| author | Esra Cataltepe Eda Ceker Ayse Fadiloglu Fatih Gungor Nermin Karakurt Zekeriya Ulger Hacer Dogan Varan |
| author_facet | Esra Cataltepe Eda Ceker Ayse Fadiloglu Fatih Gungor Nermin Karakurt Zekeriya Ulger Hacer Dogan Varan |
| author_sort | Esra Cataltepe |
| collection | DOAJ |
| description | Abstract Background Chronic inflammation is increasingly recognized as a crucial contributor to sarcopenia pathogenesis, but accurate diagnosis remains a challenge. Aim Our study aims to investigate the relationship between sarcopenia and the Systemic Immune-Inflammation Index (SII), a comprehensive indicator of inflammation. Methods This cross-sectional study enrolled 632 patients. All participants underwent a comprehensive geriatric assessment. Sarcopenia was assessed through the evaluation of handgrip strength and calf circumference. To determine the SII, we used the formula: Platelet count (109/mm3)×Neutrophil count (109/mm3) / Lymphocyte count (109/mm3). Results The average age of the participants was 74.8 ± 6.4, and 62.3% (n = 394) were female. Patients were grouped as non-sarcopenic and sarcopenic. The non-sarcopenic group had 536 patients (84.8%), while the sarcopenic group comprised 96 patients (15.2%). Sarcopenic patients showed a higher median SII score than the non-sarcopenic group (p < 0.001). Multivariate logistic regression analysis revealed that the SII score was significantly and independently associated with sarcopenia even after adjusting for potential confounding factors (β = 1.002, 95% CI = 1.001–1.003, p < 0.001). The ROC analysis identified the optimal cut-off for SII in predicting sarcopenia as > 765. At this threshold, the negative predictive values were determined to be 88.1%, with a specificity of 88%. Conclusion SII is significantly associated with sarcopenia in a geriatric outpatient population, and a population-specific SII cut-off may serve as a novel, simple, and practical biomarker for diagnosing sarcopenia. |
| format | Article |
| id | doaj-art-35dba668af6c4226a6e0db4d2a63a749 |
| institution | Kabale University |
| issn | 1471-2318 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj-art-35dba668af6c4226a6e0db4d2a63a7492025-01-19T12:38:04ZengBMCBMC Geriatrics1471-23182025-01-012511710.1186/s12877-025-05686-2Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional studyEsra Cataltepe0Eda Ceker1Ayse Fadiloglu2Fatih Gungor3Nermin Karakurt4Zekeriya Ulger5Hacer Dogan Varan6Faculty of Medicine, Department of Geriatric Medicine, Gazi UniversityFaculty of Medicine, Department of Geriatric Medicine, Gazi UniversityFaculty of Medicine, Department of Geriatric Medicine, Gazi UniversityFaculty of Medicine, Department of Geriatric Medicine, Gazi UniversityFaculty of Medicine, Department of Geriatric Medicine, Gazi UniversityFaculty of Medicine, Department of Geriatric Medicine, Gazi UniversityFaculty of Medicine, Department of Geriatric Medicine, Gazi UniversityAbstract Background Chronic inflammation is increasingly recognized as a crucial contributor to sarcopenia pathogenesis, but accurate diagnosis remains a challenge. Aim Our study aims to investigate the relationship between sarcopenia and the Systemic Immune-Inflammation Index (SII), a comprehensive indicator of inflammation. Methods This cross-sectional study enrolled 632 patients. All participants underwent a comprehensive geriatric assessment. Sarcopenia was assessed through the evaluation of handgrip strength and calf circumference. To determine the SII, we used the formula: Platelet count (109/mm3)×Neutrophil count (109/mm3) / Lymphocyte count (109/mm3). Results The average age of the participants was 74.8 ± 6.4, and 62.3% (n = 394) were female. Patients were grouped as non-sarcopenic and sarcopenic. The non-sarcopenic group had 536 patients (84.8%), while the sarcopenic group comprised 96 patients (15.2%). Sarcopenic patients showed a higher median SII score than the non-sarcopenic group (p < 0.001). Multivariate logistic regression analysis revealed that the SII score was significantly and independently associated with sarcopenia even after adjusting for potential confounding factors (β = 1.002, 95% CI = 1.001–1.003, p < 0.001). The ROC analysis identified the optimal cut-off for SII in predicting sarcopenia as > 765. At this threshold, the negative predictive values were determined to be 88.1%, with a specificity of 88%. Conclusion SII is significantly associated with sarcopenia in a geriatric outpatient population, and a population-specific SII cut-off may serve as a novel, simple, and practical biomarker for diagnosing sarcopenia.https://doi.org/10.1186/s12877-025-05686-2Systemic immune-inflammation indexSarcopeniaInflammation |
| spellingShingle | Esra Cataltepe Eda Ceker Ayse Fadiloglu Fatih Gungor Nermin Karakurt Zekeriya Ulger Hacer Dogan Varan Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study BMC Geriatrics Systemic immune-inflammation index Sarcopenia Inflammation |
| title | Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study |
| title_full | Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study |
| title_fullStr | Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study |
| title_full_unstemmed | Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study |
| title_short | Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study |
| title_sort | association between the systemic immune inflammation index and sarcopenia in older adults a cross sectional study |
| topic | Systemic immune-inflammation index Sarcopenia Inflammation |
| url | https://doi.org/10.1186/s12877-025-05686-2 |
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