Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse
Pulmonary alveolar proteinosis (PAP) is a rare lung disorder in which defects in alveolar macrophage maturation or function lead to the accumulation of proteinaceous surfactant in alveolar space, resulting in impaired gas exchange and hypoxemia. PAP is categorized into three types: hereditary, autoi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2018/5202173 |
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| author | Meirui Li Salem Alowami Miranda Schell Clive Davis Asghar Naqvi |
| author_facet | Meirui Li Salem Alowami Miranda Schell Clive Davis Asghar Naqvi |
| author_sort | Meirui Li |
| collection | DOAJ |
| description | Pulmonary alveolar proteinosis (PAP) is a rare lung disorder in which defects in alveolar macrophage maturation or function lead to the accumulation of proteinaceous surfactant in alveolar space, resulting in impaired gas exchange and hypoxemia. PAP is categorized into three types: hereditary, autoimmune, and secondary. We report a case of secondary PAP in a 47-year-old man, whose risk factors include occupational exposure to inhaled toxins, especially aluminum dust, the use of anabolic steroids, and alcohol abuse, which in mice leads to alveolar macrophage dysfunction through a zinc-dependent mechanism that inhibits granulocyte macrophage-colony stimulating factor (GM-CSF) receptor signalling. Although the rarity and vague clinical presentation of PAP can pose diagnostic challenges, clinician awareness of PAP risk factors may facilitate the diagnostic process and lead to more prompt treatment. |
| format | Article |
| id | doaj-art-35d85f1b96a94acd9003cfcb4672d65b |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-35d85f1b96a94acd9003cfcb4672d65b2025-02-03T05:50:14ZengWileyCase Reports in Pulmonology2090-68462090-68542018-01-01201810.1155/2018/52021735202173Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance AbuseMeirui Li0Salem Alowami1Miranda Schell2Clive Davis3Asghar Naqvi4Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, CanadaDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, CanadaDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, CanadaDivisions of Critical Care, Respirology, and General Internal Medicine, Department of Medicine, McMaster University, Hamilton, ON, CanadaDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, CanadaPulmonary alveolar proteinosis (PAP) is a rare lung disorder in which defects in alveolar macrophage maturation or function lead to the accumulation of proteinaceous surfactant in alveolar space, resulting in impaired gas exchange and hypoxemia. PAP is categorized into three types: hereditary, autoimmune, and secondary. We report a case of secondary PAP in a 47-year-old man, whose risk factors include occupational exposure to inhaled toxins, especially aluminum dust, the use of anabolic steroids, and alcohol abuse, which in mice leads to alveolar macrophage dysfunction through a zinc-dependent mechanism that inhibits granulocyte macrophage-colony stimulating factor (GM-CSF) receptor signalling. Although the rarity and vague clinical presentation of PAP can pose diagnostic challenges, clinician awareness of PAP risk factors may facilitate the diagnostic process and lead to more prompt treatment.http://dx.doi.org/10.1155/2018/5202173 |
| spellingShingle | Meirui Li Salem Alowami Miranda Schell Clive Davis Asghar Naqvi Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse Case Reports in Pulmonology |
| title | Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse |
| title_full | Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse |
| title_fullStr | Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse |
| title_full_unstemmed | Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse |
| title_short | Pulmonary Alveolar Proteinosis in Setting of Inhaled Toxin Exposure and Chronic Substance Abuse |
| title_sort | pulmonary alveolar proteinosis in setting of inhaled toxin exposure and chronic substance abuse |
| url | http://dx.doi.org/10.1155/2018/5202173 |
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