Asystole after Orthotopic Lung Transplantation: Examining the Interaction of Cardiac Denervation and Dexmedetomidine
Dexmedetomidine is an α2-receptor agonist commonly used for sedation and analgesia in ICU patients. Dexmedetomidine is known to provide sympatholysis and also to have direct atrioventricular and sinoatrial node inhibitory effects. In rare instances, orthotopic lung transplantation has been associate...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Anesthesiology |
| Online Access: | http://dx.doi.org/10.1155/2012/203240 |
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| author | Christopher Allen-John Webb Paul David Weyker Brigid Colleen Flynn |
| author_facet | Christopher Allen-John Webb Paul David Weyker Brigid Colleen Flynn |
| author_sort | Christopher Allen-John Webb |
| collection | DOAJ |
| description | Dexmedetomidine is an α2-receptor agonist commonly used for sedation and analgesia in ICU patients. Dexmedetomidine is known to provide sympatholysis and also to have direct atrioventricular and sinoatrial node inhibitory effects. In rare instances, orthotopic lung transplantation has been associated with disruption of autonomic innervation of the heart. The combination of this autonomic disruption and dexmedetomidine may be associated with severe bradycardia and/or asystole. Since orthotopic lung transplant patients with parasympathetic denervation will not respond with increased heart rate to anticholinergic therapy, bradyarrhythmias must be recognized and promptly treated with direct acting beta agonists to avoid asystolic cardiac events. |
| format | Article |
| id | doaj-art-35d6b92cbcc34d9894dd64d7bb91effa |
| institution | Kabale University |
| issn | 2090-6382 2090-6390 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Anesthesiology |
| spelling | doaj-art-35d6b92cbcc34d9894dd64d7bb91effa2025-02-03T01:32:28ZengWileyCase Reports in Anesthesiology2090-63822090-63902012-01-01201210.1155/2012/203240203240Asystole after Orthotopic Lung Transplantation: Examining the Interaction of Cardiac Denervation and DexmedetomidineChristopher Allen-John Webb0Paul David Weyker1Brigid Colleen Flynn2Columbia University College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USAColumbia University College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USAColumbia University College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USADexmedetomidine is an α2-receptor agonist commonly used for sedation and analgesia in ICU patients. Dexmedetomidine is known to provide sympatholysis and also to have direct atrioventricular and sinoatrial node inhibitory effects. In rare instances, orthotopic lung transplantation has been associated with disruption of autonomic innervation of the heart. The combination of this autonomic disruption and dexmedetomidine may be associated with severe bradycardia and/or asystole. Since orthotopic lung transplant patients with parasympathetic denervation will not respond with increased heart rate to anticholinergic therapy, bradyarrhythmias must be recognized and promptly treated with direct acting beta agonists to avoid asystolic cardiac events.http://dx.doi.org/10.1155/2012/203240 |
| spellingShingle | Christopher Allen-John Webb Paul David Weyker Brigid Colleen Flynn Asystole after Orthotopic Lung Transplantation: Examining the Interaction of Cardiac Denervation and Dexmedetomidine Case Reports in Anesthesiology |
| title | Asystole after Orthotopic Lung Transplantation: Examining the Interaction of Cardiac Denervation and Dexmedetomidine |
| title_full | Asystole after Orthotopic Lung Transplantation: Examining the Interaction of Cardiac Denervation and Dexmedetomidine |
| title_fullStr | Asystole after Orthotopic Lung Transplantation: Examining the Interaction of Cardiac Denervation and Dexmedetomidine |
| title_full_unstemmed | Asystole after Orthotopic Lung Transplantation: Examining the Interaction of Cardiac Denervation and Dexmedetomidine |
| title_short | Asystole after Orthotopic Lung Transplantation: Examining the Interaction of Cardiac Denervation and Dexmedetomidine |
| title_sort | asystole after orthotopic lung transplantation examining the interaction of cardiac denervation and dexmedetomidine |
| url | http://dx.doi.org/10.1155/2012/203240 |
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