Acute Pancreatitis: An Unusual Side Effect of Adalimumab in Crohn’s Disease Patient
Background: Drug-induced acute pancreatitis is a rare condition occurs at an incidence rate of 0.1–1.4% and represents a diagnostic challenge. TNFα inhibitors specially adalimumab is very rarely reported in the literature, primarily through case reports, as a potential cause of acute pancreatitis. C...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Clinical Medicine Insights: Case Reports |
| Online Access: | https://doi.org/10.1177/11795476251315000 |
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| author | Walid El Ouardi Mustapha Benazzouz |
| author_facet | Walid El Ouardi Mustapha Benazzouz |
| author_sort | Walid El Ouardi |
| collection | DOAJ |
| description | Background: Drug-induced acute pancreatitis is a rare condition occurs at an incidence rate of 0.1–1.4% and represents a diagnostic challenge. TNFα inhibitors specially adalimumab is very rarely reported in the literature, primarily through case reports, as a potential cause of acute pancreatitis. Case presentation: Our case report presents a case of a 23-year-old patient followed for Crohn disease in whom a diagnosis of acute pancreatitis induced by adalimumab was made. This diagnosis was confirmed after the elimination of other possible etiologies, and notably by the recurrence of pancreatitis after Adalimumab rechallenge. The occurrence of acute pancreatitis induced by TNFα inhibitors exposes to the risk of pancreatitis with other drugs in this class, hence the need to switch to another therapeutic class, which was Ustekinumab in our case. Conclusion: Acute pancreatitis is an unusual complication of treatment with Adalimumab. Through our experience, based on solid scientific data, we want to draw the attention of clinicians to the reality of this complication. It should be considered in any patient on TNFα inhibitors who presents with acute pancreatitis without an obvious cause. |
| format | Article |
| id | doaj-art-35cf5767c9404df5842fcc4952264337 |
| institution | Kabale University |
| issn | 1179-5476 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Case Reports |
| spelling | doaj-art-35cf5767c9404df5842fcc49522643372025-01-22T14:03:25ZengSAGE PublishingClinical Medicine Insights: Case Reports1179-54762025-01-011810.1177/11795476251315000Acute Pancreatitis: An Unusual Side Effect of Adalimumab in Crohn’s Disease PatientWalid El Ouardi0Mustapha Benazzouz1Resident in Gastroenterology, Faculty of Medicine and Pharmacy, Rabat, MoroccoDepartment of Gastroenterology, International University of Rabat/Riad Annakhil International Polyclinic, Rabat, MoroccoBackground: Drug-induced acute pancreatitis is a rare condition occurs at an incidence rate of 0.1–1.4% and represents a diagnostic challenge. TNFα inhibitors specially adalimumab is very rarely reported in the literature, primarily through case reports, as a potential cause of acute pancreatitis. Case presentation: Our case report presents a case of a 23-year-old patient followed for Crohn disease in whom a diagnosis of acute pancreatitis induced by adalimumab was made. This diagnosis was confirmed after the elimination of other possible etiologies, and notably by the recurrence of pancreatitis after Adalimumab rechallenge. The occurrence of acute pancreatitis induced by TNFα inhibitors exposes to the risk of pancreatitis with other drugs in this class, hence the need to switch to another therapeutic class, which was Ustekinumab in our case. Conclusion: Acute pancreatitis is an unusual complication of treatment with Adalimumab. Through our experience, based on solid scientific data, we want to draw the attention of clinicians to the reality of this complication. It should be considered in any patient on TNFα inhibitors who presents with acute pancreatitis without an obvious cause.https://doi.org/10.1177/11795476251315000 |
| spellingShingle | Walid El Ouardi Mustapha Benazzouz Acute Pancreatitis: An Unusual Side Effect of Adalimumab in Crohn’s Disease Patient Clinical Medicine Insights: Case Reports |
| title | Acute Pancreatitis: An Unusual Side Effect of Adalimumab in Crohn’s Disease Patient |
| title_full | Acute Pancreatitis: An Unusual Side Effect of Adalimumab in Crohn’s Disease Patient |
| title_fullStr | Acute Pancreatitis: An Unusual Side Effect of Adalimumab in Crohn’s Disease Patient |
| title_full_unstemmed | Acute Pancreatitis: An Unusual Side Effect of Adalimumab in Crohn’s Disease Patient |
| title_short | Acute Pancreatitis: An Unusual Side Effect of Adalimumab in Crohn’s Disease Patient |
| title_sort | acute pancreatitis an unusual side effect of adalimumab in crohn s disease patient |
| url | https://doi.org/10.1177/11795476251315000 |
| work_keys_str_mv | AT walidelouardi acutepancreatitisanunusualsideeffectofadalimumabincrohnsdiseasepatient AT mustaphabenazzouz acutepancreatitisanunusualsideeffectofadalimumabincrohnsdiseasepatient |