Organoid Models for Salivary Gland Biology and Regenerative Medicine
The salivary gland is composed of an elegant epithelial network that secrets saliva and maintains oral homeostasis. While cell lines and animal models furthered our understanding of salivary gland biology, they cannot replicate key aspects of the human salivary gland tissue, particularly the complex...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/9922597 |
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| _version_ | 1832565914755661824 |
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| author | Chen Zhao Cuida Meng Na Cui Jichao Sha Liwei Sun Dongdong Zhu |
| author_facet | Chen Zhao Cuida Meng Na Cui Jichao Sha Liwei Sun Dongdong Zhu |
| author_sort | Chen Zhao |
| collection | DOAJ |
| description | The salivary gland is composed of an elegant epithelial network that secrets saliva and maintains oral homeostasis. While cell lines and animal models furthered our understanding of salivary gland biology, they cannot replicate key aspects of the human salivary gland tissue, particularly the complex architecture and microenvironmental features that dictate salivary gland function. Organoid cultures provide an alternative system to recapitulate salivary gland tissue in vitro, and salivary gland organoids have been generated from pluripotent stem cells and adult stem/progenitor cells. In this review, we describe salivary gland organoids, the advances and limitations, and the promising potential for regenerative medicine. |
| format | Article |
| id | doaj-art-35ae8014b8d542848c910a8e215e2703 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-35ae8014b8d542848c910a8e215e27032025-02-03T01:05:32ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/99225979922597Organoid Models for Salivary Gland Biology and Regenerative MedicineChen Zhao0Cuida Meng1Na Cui2Jichao Sha3Liwei Sun4Dongdong Zhu5Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaThe salivary gland is composed of an elegant epithelial network that secrets saliva and maintains oral homeostasis. While cell lines and animal models furthered our understanding of salivary gland biology, they cannot replicate key aspects of the human salivary gland tissue, particularly the complex architecture and microenvironmental features that dictate salivary gland function. Organoid cultures provide an alternative system to recapitulate salivary gland tissue in vitro, and salivary gland organoids have been generated from pluripotent stem cells and adult stem/progenitor cells. In this review, we describe salivary gland organoids, the advances and limitations, and the promising potential for regenerative medicine.http://dx.doi.org/10.1155/2021/9922597 |
| spellingShingle | Chen Zhao Cuida Meng Na Cui Jichao Sha Liwei Sun Dongdong Zhu Organoid Models for Salivary Gland Biology and Regenerative Medicine Stem Cells International |
| title | Organoid Models for Salivary Gland Biology and Regenerative Medicine |
| title_full | Organoid Models for Salivary Gland Biology and Regenerative Medicine |
| title_fullStr | Organoid Models for Salivary Gland Biology and Regenerative Medicine |
| title_full_unstemmed | Organoid Models for Salivary Gland Biology and Regenerative Medicine |
| title_short | Organoid Models for Salivary Gland Biology and Regenerative Medicine |
| title_sort | organoid models for salivary gland biology and regenerative medicine |
| url | http://dx.doi.org/10.1155/2021/9922597 |
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