C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome
Neonatal lupus syndrome (NLS) is a rare, passively acquired autoimmune syndrome caused by maternal autoantibodies. We describe a case of a newborn with NLS and the accompanying placental findings. A female neonate was born by emergency cesarean delivery due to non-reassuring fetal status at 35 weeks...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2019/5863476 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545493743304704 |
|---|---|
| author | Yuichiro Sato Tomoko Yamaguchi Jyunsuke Muraoka Hajime Taniguchi Atsushi Kisanuki Kazunari Maekawa Atushi Yamashita Murasaki Aman Yuki Kodama Hiroshi Sameshima Yujiro Asada |
| author_facet | Yuichiro Sato Tomoko Yamaguchi Jyunsuke Muraoka Hajime Taniguchi Atsushi Kisanuki Kazunari Maekawa Atushi Yamashita Murasaki Aman Yuki Kodama Hiroshi Sameshima Yujiro Asada |
| author_sort | Yuichiro Sato |
| collection | DOAJ |
| description | Neonatal lupus syndrome (NLS) is a rare, passively acquired autoimmune syndrome caused by maternal autoantibodies. We describe a case of a newborn with NLS and the accompanying placental findings. A female neonate was born by emergency cesarean delivery due to non-reassuring fetal status at 35 weeks and 3 days. This neonate had congenital erythematous and scar lesions on the face, back, and upper and lower extremities. Maternal and fetal anti-SSA and SSB antibodies were elevated and this baby was diagnosed as NLS. Histologically, the chorionic villi demonstrated capillary shrinkage. An immunohistochemical study revealed complement deposition (C4d) in the capillaries of the villi and umbilical vessels. Our findings suggest that maternal autoantibodies affect the inflammatory response of the fetus through the placenta and that C4d deposition may be useful for diagnosing NLS. |
| format | Article |
| id | doaj-art-35ada0a16cb64b88aa6c2c3837541319 |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-35ada0a16cb64b88aa6c2c38375413192025-02-03T07:25:29ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922019-01-01201910.1155/2019/58634765863476C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus SyndromeYuichiro Sato0Tomoko Yamaguchi1Jyunsuke Muraoka2Hajime Taniguchi3Atsushi Kisanuki4Kazunari Maekawa5Atushi Yamashita6Murasaki Aman7Yuki Kodama8Hiroshi Sameshima9Yujiro Asada10Department of Diagnostic Pathology, Faculty of Medicine, Miyazaki University Hospital, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Obstetrics and Gynecology, Miyazaki Prefectural Nichinan Hospital, 1-9-5, Kiyama, Nichinan, Miyazaki 887-0013, JapanDepartment of Obstetrics and Gynecology, Miyazaki Prefectural Nichinan Hospital, 1-9-5, Kiyama, Nichinan, Miyazaki 887-0013, JapanDepartment of Obstetrics and Gynecology, Miyazaki Prefectural Nichinan Hospital, 1-9-5, Kiyama, Nichinan, Miyazaki 887-0013, JapanDepartment of Diagnostic Pathology, Miyazaki Prefectural Nichinan Hospital, 1-9-5, Kiyama, Nichinan, Miyazaki 887-0013, JapanDepartment of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Diagnostic Pathology, Faculty of Medicine, Miyazaki University Hospital, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanNeonatal lupus syndrome (NLS) is a rare, passively acquired autoimmune syndrome caused by maternal autoantibodies. We describe a case of a newborn with NLS and the accompanying placental findings. A female neonate was born by emergency cesarean delivery due to non-reassuring fetal status at 35 weeks and 3 days. This neonate had congenital erythematous and scar lesions on the face, back, and upper and lower extremities. Maternal and fetal anti-SSA and SSB antibodies were elevated and this baby was diagnosed as NLS. Histologically, the chorionic villi demonstrated capillary shrinkage. An immunohistochemical study revealed complement deposition (C4d) in the capillaries of the villi and umbilical vessels. Our findings suggest that maternal autoantibodies affect the inflammatory response of the fetus through the placenta and that C4d deposition may be useful for diagnosing NLS.http://dx.doi.org/10.1155/2019/5863476 |
| spellingShingle | Yuichiro Sato Tomoko Yamaguchi Jyunsuke Muraoka Hajime Taniguchi Atsushi Kisanuki Kazunari Maekawa Atushi Yamashita Murasaki Aman Yuki Kodama Hiroshi Sameshima Yujiro Asada C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome Case Reports in Obstetrics and Gynecology |
| title | C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome |
| title_full | C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome |
| title_fullStr | C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome |
| title_full_unstemmed | C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome |
| title_short | C4d Deposition in Fetal Vessels of the Placenta in Neonatal Lupus Syndrome |
| title_sort | c4d deposition in fetal vessels of the placenta in neonatal lupus syndrome |
| url | http://dx.doi.org/10.1155/2019/5863476 |
| work_keys_str_mv | AT yuichirosato c4ddepositioninfetalvesselsoftheplacentainneonatallupussyndrome AT tomokoyamaguchi c4ddepositioninfetalvesselsoftheplacentainneonatallupussyndrome AT jyunsukemuraoka c4ddepositioninfetalvesselsoftheplacentainneonatallupussyndrome AT hajimetaniguchi c4ddepositioninfetalvesselsoftheplacentainneonatallupussyndrome AT atsushikisanuki c4ddepositioninfetalvesselsoftheplacentainneonatallupussyndrome AT kazunarimaekawa c4ddepositioninfetalvesselsoftheplacentainneonatallupussyndrome AT atushiyamashita c4ddepositioninfetalvesselsoftheplacentainneonatallupussyndrome AT murasakiaman c4ddepositioninfetalvesselsoftheplacentainneonatallupussyndrome AT yukikodama c4ddepositioninfetalvesselsoftheplacentainneonatallupussyndrome AT hiroshisameshima c4ddepositioninfetalvesselsoftheplacentainneonatallupussyndrome AT yujiroasada c4ddepositioninfetalvesselsoftheplacentainneonatallupussyndrome |