Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance
Background. Pregnancy maintenance depends on the formation of normal placentas accompanied by trophoblast invasion and vascular remodeling. Various types of cells, such as trophoblasts, endothelial cells, immune cells, mesenchymal stem cells (MSCs), and adipocytes, mediate cell-to-cell interactions...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/5558048 |
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| author | Zengfang Wang Ruizhen Yang Jiaojiao Zhang Pingping Wang Zengyan Wang Jian Gao Xue Liu |
| author_facet | Zengfang Wang Ruizhen Yang Jiaojiao Zhang Pingping Wang Zengyan Wang Jian Gao Xue Liu |
| author_sort | Zengfang Wang |
| collection | DOAJ |
| description | Background. Pregnancy maintenance depends on the formation of normal placentas accompanied by trophoblast invasion and vascular remodeling. Various types of cells, such as trophoblasts, endothelial cells, immune cells, mesenchymal stem cells (MSCs), and adipocytes, mediate cell-to-cell interactions through soluble factors to maintain normal placental development. Extracellular vesicles (EVs) are diverse nanosized to microsized membrane-bound particles released from various cells. EVs contain tens to thousands of different RNA, proteins, small molecules, DNA fragments, and bioactive lipids. EV-derived microRNAs (miRNAs) and proteins regulate inflammation and trophoblast invasion in the placental microenvironment. Maternal-fetal communication through EV can regulate the key signaling pathways involved in pregnancy maintenance, from implantation to immune regulation. Therefore, EVs and the encapsulating factors play important roles in pregnancy, some of which might be potential biomarkers. Conclusion. In this review, we have summarized published studies about the EVs in the placentation and pregnancy-related diseases. By summarizing the role of EVs and their delivering active molecules in pregnancy-related diseases, it provides novel insight into the diagnosis and treatment of diseases. |
| format | Article |
| id | doaj-art-35a843142095413691af9dd946d575c9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-35a843142095413691af9dd946d575c92025-02-03T07:24:01ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/55580485558048Role of Extracellular Vesicles in Placental Inflammation and Local Immune BalanceZengfang Wang0Ruizhen Yang1Jiaojiao Zhang2Pingping Wang3Zengyan Wang4Jian Gao5Xue Liu6Department of Gynecology and Obstetrics, Maternal and Child Health Hospital of Weifang Medical University, Weifang 261000, ChinaOperating Room, Zhucheng People’s Hospital, Zhucheng 262200, ChinaCentral Laboratory of Weifang People’s Hospital, Weifang 261000, ChinaDepartment of Gynecology and Obstetrics, Maternal and Child Health Hospital of Weifang Medical University, Weifang 261000, ChinaOperating Room, Zhucheng People’s Hospital, Zhucheng 262200, ChinaDepartment of Paediatrics, Maternal and Child Health Care Hospital of Weifang, Weifang 261000, ChinaOperating Room, Zhucheng People’s Hospital, Zhucheng 262200, ChinaBackground. Pregnancy maintenance depends on the formation of normal placentas accompanied by trophoblast invasion and vascular remodeling. Various types of cells, such as trophoblasts, endothelial cells, immune cells, mesenchymal stem cells (MSCs), and adipocytes, mediate cell-to-cell interactions through soluble factors to maintain normal placental development. Extracellular vesicles (EVs) are diverse nanosized to microsized membrane-bound particles released from various cells. EVs contain tens to thousands of different RNA, proteins, small molecules, DNA fragments, and bioactive lipids. EV-derived microRNAs (miRNAs) and proteins regulate inflammation and trophoblast invasion in the placental microenvironment. Maternal-fetal communication through EV can regulate the key signaling pathways involved in pregnancy maintenance, from implantation to immune regulation. Therefore, EVs and the encapsulating factors play important roles in pregnancy, some of which might be potential biomarkers. Conclusion. In this review, we have summarized published studies about the EVs in the placentation and pregnancy-related diseases. By summarizing the role of EVs and their delivering active molecules in pregnancy-related diseases, it provides novel insight into the diagnosis and treatment of diseases.http://dx.doi.org/10.1155/2021/5558048 |
| spellingShingle | Zengfang Wang Ruizhen Yang Jiaojiao Zhang Pingping Wang Zengyan Wang Jian Gao Xue Liu Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance Mediators of Inflammation |
| title | Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance |
| title_full | Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance |
| title_fullStr | Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance |
| title_full_unstemmed | Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance |
| title_short | Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance |
| title_sort | role of extracellular vesicles in placental inflammation and local immune balance |
| url | http://dx.doi.org/10.1155/2021/5558048 |
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