Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study
Traffic-related air pollution (TRAP) has been linked with numerous respiratory diseases. Recently, lung microbiome is proposed to be characterized with development and progression of respiratory diseases. However, the underlying effects of TRAP exposure on lung microbiome are rarely explored. We con...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132401621X |
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| author | Rongrong Xu Yanping Zhang Tingting Wu Hao Liu Jianhao Peng Zhanshan Wang Te Ba Baorong Zhang Zhigang Li Yongjie Wei |
| author_facet | Rongrong Xu Yanping Zhang Tingting Wu Hao Liu Jianhao Peng Zhanshan Wang Te Ba Baorong Zhang Zhigang Li Yongjie Wei |
| author_sort | Rongrong Xu |
| collection | DOAJ |
| description | Traffic-related air pollution (TRAP) has been linked with numerous respiratory diseases. Recently, lung microbiome is proposed to be characterized with development and progression of respiratory diseases. However, the underlying effects of TRAP exposure on lung microbiome are rarely explored. We conducted a randomized, crossover study among 35 healthy adults, who participated in 2-h exposure treatments in the road or park scenario alternately, to investigate the impact of short-term TRAP exposure on expiratory health. Particle matters (PMs), nitrogen dioxide (NO2), carbon monoxide (CO) and volatile organic compounds (VOCs), lung function, fractional exhaled nitric oxide (FeNO) and lung microbiota were measured. We applied linear mixed-effect models to explore the associations. TRAP including NO2 and CO in the road were about 1.5 times higher than that in the park except for PMs, and total VOCs also showed higher concentrations. We observed elevated difference in FeNO was associated with high TRAP exposure in the road session, but didn’t find obvious changes in lung function. The abundance of Lentilactobacillus and Haepmophilus were distinct in the two groups, with significant correlations with changes to PEF and FeNO, respectively. Enrichment pathways related to transcription, amino acid and carbohydrate metabolism were altered following high TRAP exposure, suggesting TRAP contributed to the respiratory disease by changing metabolism of lung microbes. Our findings reveal VOCs in the road are another key air pollutant and provide novel mechanism for the respiratory effects of TRAP from the perspective of microbiome. |
| format | Article |
| id | doaj-art-359a085b8d29426f94c8b487c103d245 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-359a085b8d29426f94c8b487c103d2452025-01-23T05:25:51ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117545Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover studyRongrong Xu0Yanping Zhang1Tingting Wu2Hao Liu3Jianhao Peng4Zhanshan Wang5Te Ba6Baorong Zhang7Zhigang Li8Yongjie Wei9College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaInstitute of Atmospheric Environment, Chinese Research Academy of Environmental ScienceCollege of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaDepartment of Stomatology, Aviation General Hospital, Beijing, ChinaDepartment of Stomatology, Aviation General Hospital, Beijing, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; Corresponding author.College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; Corresponding author at: College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.Traffic-related air pollution (TRAP) has been linked with numerous respiratory diseases. Recently, lung microbiome is proposed to be characterized with development and progression of respiratory diseases. However, the underlying effects of TRAP exposure on lung microbiome are rarely explored. We conducted a randomized, crossover study among 35 healthy adults, who participated in 2-h exposure treatments in the road or park scenario alternately, to investigate the impact of short-term TRAP exposure on expiratory health. Particle matters (PMs), nitrogen dioxide (NO2), carbon monoxide (CO) and volatile organic compounds (VOCs), lung function, fractional exhaled nitric oxide (FeNO) and lung microbiota were measured. We applied linear mixed-effect models to explore the associations. TRAP including NO2 and CO in the road were about 1.5 times higher than that in the park except for PMs, and total VOCs also showed higher concentrations. We observed elevated difference in FeNO was associated with high TRAP exposure in the road session, but didn’t find obvious changes in lung function. The abundance of Lentilactobacillus and Haepmophilus were distinct in the two groups, with significant correlations with changes to PEF and FeNO, respectively. Enrichment pathways related to transcription, amino acid and carbohydrate metabolism were altered following high TRAP exposure, suggesting TRAP contributed to the respiratory disease by changing metabolism of lung microbes. Our findings reveal VOCs in the road are another key air pollutant and provide novel mechanism for the respiratory effects of TRAP from the perspective of microbiome.http://www.sciencedirect.com/science/article/pii/S014765132401621XTraffic-related air pollutionLung microbiotaRespiratory effectRandomized crossover trial |
| spellingShingle | Rongrong Xu Yanping Zhang Tingting Wu Hao Liu Jianhao Peng Zhanshan Wang Te Ba Baorong Zhang Zhigang Li Yongjie Wei Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study Ecotoxicology and Environmental Safety Traffic-related air pollution Lung microbiota Respiratory effect Randomized crossover trial |
| title | Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study |
| title_full | Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study |
| title_fullStr | Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study |
| title_full_unstemmed | Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study |
| title_short | Traffic-related air pollution (TRAP) exposure, lung function, airway inflammation and expiratory microbiota: A randomized crossover study |
| title_sort | traffic related air pollution trap exposure lung function airway inflammation and expiratory microbiota a randomized crossover study |
| topic | Traffic-related air pollution Lung microbiota Respiratory effect Randomized crossover trial |
| url | http://www.sciencedirect.com/science/article/pii/S014765132401621X |
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