Stage-specific function of sphingolipid synthases in African trypanosomes

Stage-specific function of sphingolipid synthases in African trypanosomes

ABSTRACT The protozoan parasite Trypanosoma brucei is the only known eukaryote capable of synthesizing the three main phosphosphingolipids: sphingomyelin (SM), inositol phosphorylceramide (IPC), and ethanolamine phosphorylceramide (EPC). It has four paralogous genes encoding sphingolipid synthases (...

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Bibliographic Details
Main Authors: Norton Heise, Carolina M. Koeller, Mohamed Sharif, James D. Bangs
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mBio
Subjects:
trypanosome
sphingolipid
sphingolipid synthase
sphingomyelin
inositolphosphorylceramide
Online Access:https://journals.asm.org/doi/10.1128/mbio.03501-24
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