Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease

<b>Background and Aims:</b> Avolition is a symptom responsible for a high burden in patients suffering from psychiatric diseases. It refers to a motivation loss for initiating and maintaining goal-directed activities, often called fatigue by patients. Fatigue is a widespread complaint of...

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Main Authors: Tristan Gabriel-Segard, Margherita Boltri, Mathilde Barrau, Catherine Massoubre, Stéphane Paul, Xavier Roblin
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomedicines
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Online Access:https://www.mdpi.com/2227-9059/13/1/125
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author Tristan Gabriel-Segard
Margherita Boltri
Mathilde Barrau
Catherine Massoubre
Stéphane Paul
Xavier Roblin
author_facet Tristan Gabriel-Segard
Margherita Boltri
Mathilde Barrau
Catherine Massoubre
Stéphane Paul
Xavier Roblin
author_sort Tristan Gabriel-Segard
collection DOAJ
description <b>Background and Aims:</b> Avolition is a symptom responsible for a high burden in patients suffering from psychiatric diseases. It refers to a motivation loss for initiating and maintaining goal-directed activities, often called fatigue by patients. Fatigue is a widespread complaint of patients suffering from inflammatory bowel disease (IBD), significantly impacting patients’ well-being, even during the quiescent stage of the disease. We here address the hypothesis that fatigue experienced by IBD patients is associated with motivational impairment. <b>Methods:</b> Patients presenting IBD (n = 110) in a quiescent stage of Crohn’s disease (CD) (n = 60) and ulcerative colitis (UC) (n = 50) were enrolled and classified following their declared experience of fatigue (n = 58) or not (n = 52). Patients were phenotyped using self-administered scales for fatigue experience, bowel disease disability, quality of life and mental health symptoms. <b>Results:</b> The self-administered negative symptoms scale scores identified avolition as a specific feature of fatigue experience: fatigued vs. no-fatigue in the CD group (3.806 vs. 2.103; <i>p</i> = 0.003) and in the UC group (2.815 vs. 1.174; <i>p</i> = 0.003). This difference is independent of current depressive disorder and previous history of depressive disorder. Avolition associates and correlates with the experience of fatigue (r = 0.49) in multivariate analysis. <b>Conclusions:</b> To tackle the question of fatigue in IBD, research should consider investigating the biological mechanisms implicating intestinal physiopathology of IBD in the impairment of brain structure involved in motivation. This may open new fields for treatment in targeting structures of the brain reward system.
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spelling doaj-art-358753069df1420c8bcbcd623fa00ff02025-01-24T13:24:06ZengMDPI AGBiomedicines2227-90592025-01-0113112510.3390/biomedicines13010125Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel DiseaseTristan Gabriel-Segard0Margherita Boltri1Mathilde Barrau2Catherine Massoubre3Stéphane Paul4Xavier Roblin5Service de Psychiatrie Transversale, Centre Hospitalo-Universitaire de Saint Etienne, Hôpital Nord, 42055 Saint Etienne, FranceI.R.C.C.S. Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research, 28824 Piancavallo, ItalyCIRI—Centre International de Recherche en Infectiologie, Team GIMAP, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, CIC 1408 Vaccinology, 42023 Saint Etienne, FranceService de Psychiatrie Transversale, Centre Hospitalo-Universitaire de Saint Etienne, Hôpital Nord, 42055 Saint Etienne, FranceCIRI—Centre International de Recherche en Infectiologie, Team GIMAP, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, CIC 1408 Vaccinology, 42023 Saint Etienne, FranceCIRI—Centre International de Recherche en Infectiologie, Team GIMAP, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, CIC 1408 Vaccinology, 42023 Saint Etienne, France<b>Background and Aims:</b> Avolition is a symptom responsible for a high burden in patients suffering from psychiatric diseases. It refers to a motivation loss for initiating and maintaining goal-directed activities, often called fatigue by patients. Fatigue is a widespread complaint of patients suffering from inflammatory bowel disease (IBD), significantly impacting patients’ well-being, even during the quiescent stage of the disease. We here address the hypothesis that fatigue experienced by IBD patients is associated with motivational impairment. <b>Methods:</b> Patients presenting IBD (n = 110) in a quiescent stage of Crohn’s disease (CD) (n = 60) and ulcerative colitis (UC) (n = 50) were enrolled and classified following their declared experience of fatigue (n = 58) or not (n = 52). Patients were phenotyped using self-administered scales for fatigue experience, bowel disease disability, quality of life and mental health symptoms. <b>Results:</b> The self-administered negative symptoms scale scores identified avolition as a specific feature of fatigue experience: fatigued vs. no-fatigue in the CD group (3.806 vs. 2.103; <i>p</i> = 0.003) and in the UC group (2.815 vs. 1.174; <i>p</i> = 0.003). This difference is independent of current depressive disorder and previous history of depressive disorder. Avolition associates and correlates with the experience of fatigue (r = 0.49) in multivariate analysis. <b>Conclusions:</b> To tackle the question of fatigue in IBD, research should consider investigating the biological mechanisms implicating intestinal physiopathology of IBD in the impairment of brain structure involved in motivation. This may open new fields for treatment in targeting structures of the brain reward system.https://www.mdpi.com/2227-9059/13/1/125inflammatory bowel diseasefatigueavolitionnegative syndromemotivation
spellingShingle Tristan Gabriel-Segard
Margherita Boltri
Mathilde Barrau
Catherine Massoubre
Stéphane Paul
Xavier Roblin
Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease
Biomedicines
inflammatory bowel disease
fatigue
avolition
negative syndrome
motivation
title Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease
title_full Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease
title_fullStr Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease
title_full_unstemmed Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease
title_short Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease
title_sort avolition characterizes the chronic fatigue experienced in quiescent inflammatory bowel disease
topic inflammatory bowel disease
fatigue
avolition
negative syndrome
motivation
url https://www.mdpi.com/2227-9059/13/1/125
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AT mathildebarrau avolitioncharacterizesthechronicfatigueexperiencedinquiescentinflammatoryboweldisease
AT catherinemassoubre avolitioncharacterizesthechronicfatigueexperiencedinquiescentinflammatoryboweldisease
AT stephanepaul avolitioncharacterizesthechronicfatigueexperiencedinquiescentinflammatoryboweldisease
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