Neuropsychiatric Disorder Associated with Group G Streptococcus Infection
Immune-mediated central nervous system manifestations of group A β-hemolytic Streptococcus (GABHS) infection include Sydenham’s chorea, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS)—which includes tic and obsessive compulsive disorders—and a variety...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2018/6047318 |
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| _version_ | 1832554625678442496 |
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| author | Rie Okumura Sawako Yamazaki Tsukasa Ohashi Shinichi Magara Jun Tohyama Hiroshi Sakuma Masaharu Hayashi Akihiko Saitoh |
| author_facet | Rie Okumura Sawako Yamazaki Tsukasa Ohashi Shinichi Magara Jun Tohyama Hiroshi Sakuma Masaharu Hayashi Akihiko Saitoh |
| author_sort | Rie Okumura |
| collection | DOAJ |
| description | Immune-mediated central nervous system manifestations of group A β-hemolytic Streptococcus (GABHS) infection include Sydenham’s chorea, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS)—which includes tic and obsessive compulsive disorders—and a variety of neurobehavioral disorders. We report a case of Streptococcus dysgalactiae subspecies equisimilis (group G Streptococcus) (GGS) infection associated with involuntary movements, complex tics, and emotional lability in an 11-year-old Japanese girl. Serum IgM and IgG antibodies to lysoganglioside were positive, and she responded rapidly to intravenous immunoglobulin treatment. Neuropsychiatric disorder associated with GGS infection was ultimately diagnosed. The present findings suggest that neuropsychiatric disorders can result from GGS infection and that the pathogenic mechanism is similar to that of GABHS infection. Future large-scale studies should examine the relation between GGS infection and onset of neuropsychiatric disorder. |
| format | Article |
| id | doaj-art-356f976dde4649c89af6d0111de1763f |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-356f976dde4649c89af6d0111de1763f2025-02-03T05:50:57ZengWileyCase Reports in Pediatrics2090-68032090-68112018-01-01201810.1155/2018/60473186047318Neuropsychiatric Disorder Associated with Group G Streptococcus InfectionRie Okumura0Sawako Yamazaki1Tsukasa Ohashi2Shinichi Magara3Jun Tohyama4Hiroshi Sakuma5Masaharu Hayashi6Akihiko Saitoh7Department of Pediatrics, Niigata City General Hospital, Niigata, JapanDepartment of Pediatrics, Niigata City General Hospital, Niigata, JapanDepartment of Child Neurology, Nishi-Niigata Chuo National Hospital, Niigata, JapanDepartment of Child Neurology, Nishi-Niigata Chuo National Hospital, Niigata, JapanDepartment of Child Neurology, Nishi-Niigata Chuo National Hospital, Niigata, JapanDepartment of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Tokyo, JapanSchool of Nursing, College of Nursing and Nutrition, Shukutoku University, Chiba, JapanDepartment of Pediatrics, Niigata University, Niigata, JapanImmune-mediated central nervous system manifestations of group A β-hemolytic Streptococcus (GABHS) infection include Sydenham’s chorea, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS)—which includes tic and obsessive compulsive disorders—and a variety of neurobehavioral disorders. We report a case of Streptococcus dysgalactiae subspecies equisimilis (group G Streptococcus) (GGS) infection associated with involuntary movements, complex tics, and emotional lability in an 11-year-old Japanese girl. Serum IgM and IgG antibodies to lysoganglioside were positive, and she responded rapidly to intravenous immunoglobulin treatment. Neuropsychiatric disorder associated with GGS infection was ultimately diagnosed. The present findings suggest that neuropsychiatric disorders can result from GGS infection and that the pathogenic mechanism is similar to that of GABHS infection. Future large-scale studies should examine the relation between GGS infection and onset of neuropsychiatric disorder.http://dx.doi.org/10.1155/2018/6047318 |
| spellingShingle | Rie Okumura Sawako Yamazaki Tsukasa Ohashi Shinichi Magara Jun Tohyama Hiroshi Sakuma Masaharu Hayashi Akihiko Saitoh Neuropsychiatric Disorder Associated with Group G Streptococcus Infection Case Reports in Pediatrics |
| title | Neuropsychiatric Disorder Associated with Group G Streptococcus Infection |
| title_full | Neuropsychiatric Disorder Associated with Group G Streptococcus Infection |
| title_fullStr | Neuropsychiatric Disorder Associated with Group G Streptococcus Infection |
| title_full_unstemmed | Neuropsychiatric Disorder Associated with Group G Streptococcus Infection |
| title_short | Neuropsychiatric Disorder Associated with Group G Streptococcus Infection |
| title_sort | neuropsychiatric disorder associated with group g streptococcus infection |
| url | http://dx.doi.org/10.1155/2018/6047318 |
| work_keys_str_mv | AT rieokumura neuropsychiatricdisorderassociatedwithgroupgstreptococcusinfection AT sawakoyamazaki neuropsychiatricdisorderassociatedwithgroupgstreptococcusinfection AT tsukasaohashi neuropsychiatricdisorderassociatedwithgroupgstreptococcusinfection AT shinichimagara neuropsychiatricdisorderassociatedwithgroupgstreptococcusinfection AT juntohyama neuropsychiatricdisorderassociatedwithgroupgstreptococcusinfection AT hiroshisakuma neuropsychiatricdisorderassociatedwithgroupgstreptococcusinfection AT masaharuhayashi neuropsychiatricdisorderassociatedwithgroupgstreptococcusinfection AT akihikosaitoh neuropsychiatricdisorderassociatedwithgroupgstreptococcusinfection |