Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances
ABSTRACT: Diabetes has become a global concern at present, among which type 2 diabetes mellitus (T2DM) accounts for approximately 90 %–95 % of patients. T2DM is a type of metabolic disorder syndrome that results from a genetic defect, and it is based on insulin resistance and an insulin secretion di...
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Tsinghua University Press
2022-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022000428 |
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| author | Chong Ning Yuhan Jiao Jiaqi Wang Weiwei Li Jingqiu Zhou Yi-Chieh Lee Dik-Lung Ma Chung-Hang Leung Rugang Zhu Hui-Min David Wang |
| author_facet | Chong Ning Yuhan Jiao Jiaqi Wang Weiwei Li Jingqiu Zhou Yi-Chieh Lee Dik-Lung Ma Chung-Hang Leung Rugang Zhu Hui-Min David Wang |
| author_sort | Chong Ning |
| collection | DOAJ |
| description | ABSTRACT: Diabetes has become a global concern at present, among which type 2 diabetes mellitus (T2DM) accounts for approximately 90 %–95 % of patients. T2DM is a type of metabolic disorder syndrome that results from a genetic defect, and it is based on insulin resistance and an insulin secretion disorder. The occurrence of T2DM is usually the outcome of both genetic and environmental factors and their interactions. The etiology and pathogenesis of diabetes have not been fully elucidated, and no radical therapeutic cure has been found. Patients with T2DM suffer from complications such as the development of a chronic hyperglycemic condition and even serious metabolic disorders and organ damage in the body and depression and dementia, in addition to other chronic complications. Many studies have suggested that diet is crucial in the development of diabetes and the control of blood glucose. Natural substances have the characteristics of low toxicity and few side effects and may be key to the development of diabetic health products and preventive treatments. This paper reviews the etiology, pathogenesis, risks, treatments and diets related to T2DM to summarize the types of recently available natural products, from both local and foreign sources, for lowering blood glucose at home and their application in supplementary hypoglycemic foods. The key findings and conclusions suggest that there are various known T2DM-inducing factors, including genetic and environmental factors and three types of hybrid factors. |
| format | Article |
| id | doaj-art-356a2da564b047f3874c5e607ca502c9 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-356a2da564b047f3874c5e607ca502c92025-02-03T06:55:41ZengTsinghua University PressFood Science and Human Wellness2213-45302022-09-0111511211133Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substancesChong Ning0Yuhan Jiao1Jiaqi Wang2Weiwei Li3Jingqiu Zhou4Yi-Chieh Lee5Dik-Lung Ma6Chung-Hang Leung7Rugang Zhu8Hui-Min David Wang9College of Light Industry, Liaoning University, Shenyang 110036, ChinaCollege of Light Industry, Liaoning University, Shenyang 110036, ChinaCollege of Light Industry, Liaoning University, Shenyang 110036, ChinaCollege of Light Industry, Liaoning University, Shenyang 110036, ChinaCollege of Light Industry, Liaoning University, Shenyang 110036, ChinaDepartment of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan, ChinaDepartment of Chemistry, Hong Kong Baptist University, Kowloon Tong 999077, Hong Kong, ChinaState Key Laboratoryof Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, ChinaCollege of Light Industry, Liaoning University, Shenyang 110036, China; Correspondence to: Liaoning University, Shenyang, CN 110036.Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung 402, Taiwan, China; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City 807, Taiwan, China; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung City 404, Taiwan, China; Corresponding author at: Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung 402, Taiwan.ABSTRACT: Diabetes has become a global concern at present, among which type 2 diabetes mellitus (T2DM) accounts for approximately 90 %–95 % of patients. T2DM is a type of metabolic disorder syndrome that results from a genetic defect, and it is based on insulin resistance and an insulin secretion disorder. The occurrence of T2DM is usually the outcome of both genetic and environmental factors and their interactions. The etiology and pathogenesis of diabetes have not been fully elucidated, and no radical therapeutic cure has been found. Patients with T2DM suffer from complications such as the development of a chronic hyperglycemic condition and even serious metabolic disorders and organ damage in the body and depression and dementia, in addition to other chronic complications. Many studies have suggested that diet is crucial in the development of diabetes and the control of blood glucose. Natural substances have the characteristics of low toxicity and few side effects and may be key to the development of diabetic health products and preventive treatments. This paper reviews the etiology, pathogenesis, risks, treatments and diets related to T2DM to summarize the types of recently available natural products, from both local and foreign sources, for lowering blood glucose at home and their application in supplementary hypoglycemic foods. The key findings and conclusions suggest that there are various known T2DM-inducing factors, including genetic and environmental factors and three types of hybrid factors.http://www.sciencedirect.com/science/article/pii/S2213453022000428ObesityType 2 diabetes mellitusEtiological agentDietInsulin resistanceNatural substances |
| spellingShingle | Chong Ning Yuhan Jiao Jiaqi Wang Weiwei Li Jingqiu Zhou Yi-Chieh Lee Dik-Lung Ma Chung-Hang Leung Rugang Zhu Hui-Min David Wang Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances Food Science and Human Wellness Obesity Type 2 diabetes mellitus Etiological agent Diet Insulin resistance Natural substances |
| title | Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances |
| title_full | Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances |
| title_fullStr | Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances |
| title_full_unstemmed | Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances |
| title_short | Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances |
| title_sort | recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances |
| topic | Obesity Type 2 diabetes mellitus Etiological agent Diet Insulin resistance Natural substances |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022000428 |
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