Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind Trial
Background. Dry eye disease (DED) is one of the most common complications following refractive surgery. Purpose. Evaluate the efficacy of an osmoprotective eye drop (Optive®) for the management of induced DED in refractive surgery patients. Design. Double-masked randomised controlled trial. Methods....
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Wiley
2018-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/4324590 |
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| author | R. M. Hazarbassanov N. G. T. Queiroz-Hazarbassanov J. N. Barros J. A. P. Gomes |
| author_facet | R. M. Hazarbassanov N. G. T. Queiroz-Hazarbassanov J. N. Barros J. A. P. Gomes |
| author_sort | R. M. Hazarbassanov |
| collection | DOAJ |
| description | Background. Dry eye disease (DED) is one of the most common complications following refractive surgery. Purpose. Evaluate the efficacy of an osmoprotective eye drop (Optive®) for the management of induced DED in refractive surgery patients. Design. Double-masked randomised controlled trial. Methods. Twenty-two refractive surgery patients oriented to apply FreshTears (FT; n=13) or Optive (Op; n=9), topically, QID, for 3 months. Eye exams were performed before surgery (T0) and 1-month (T1) and 3-month (T3) follow-up and consisted of tear film osmolarity, Schirmer 1 test, tear film breakup time (TBUT), fluorescein staining, and ocular surface disease index (OSDI) and patient symptoms questionnaires. Main Outcome Measures. Pain and osmolarity. Results. Pain increased significantly for FT at T3 (p<0.05). A reduction in osmolarity was observed at T1 and T3 for Op group (p<0.01) and at T3 for FT group (p<0.05). TBUT showed a decrease between T0 and T1 for FT (p<0.05). Schirmer 1 values increased significantly for Op in T1. Conclusions. Op was superior to FT in regard to pain, osmolarity, TBUT, and Schirmer 1. Osmoprotectant solutes, such as L-carnitine, could attenuate inflammation and secondary DED. Osmoprotective lubricants can be effectively applied for the prevention of refractive surgery-related dry eye symptoms and signs. |
| format | Article |
| id | doaj-art-35686add893249df8d0987c55c771ec7 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-35686add893249df8d0987c55c771ec72025-02-03T06:01:18ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/43245904324590Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind TrialR. M. Hazarbassanov0N. G. T. Queiroz-Hazarbassanov1J. N. Barros2J. A. P. Gomes3Department of Ophthalmology and Visual Sciences, Paulista Medical School, Federal University of São Paulo, São Paulo, SP, BrazilApplied Pharmacology and Toxicology Laboratory, Veterinary Pathology Department, School of Veterinary Medicine, University of São Paulo, São Paulo, SP, BrazilDepartment of Ophthalmology and Visual Sciences, Paulista Medical School, Federal University of São Paulo, São Paulo, SP, BrazilDepartment of Ophthalmology and Visual Sciences, Paulista Medical School, Federal University of São Paulo, São Paulo, SP, BrazilBackground. Dry eye disease (DED) is one of the most common complications following refractive surgery. Purpose. Evaluate the efficacy of an osmoprotective eye drop (Optive®) for the management of induced DED in refractive surgery patients. Design. Double-masked randomised controlled trial. Methods. Twenty-two refractive surgery patients oriented to apply FreshTears (FT; n=13) or Optive (Op; n=9), topically, QID, for 3 months. Eye exams were performed before surgery (T0) and 1-month (T1) and 3-month (T3) follow-up and consisted of tear film osmolarity, Schirmer 1 test, tear film breakup time (TBUT), fluorescein staining, and ocular surface disease index (OSDI) and patient symptoms questionnaires. Main Outcome Measures. Pain and osmolarity. Results. Pain increased significantly for FT at T3 (p<0.05). A reduction in osmolarity was observed at T1 and T3 for Op group (p<0.01) and at T3 for FT group (p<0.05). TBUT showed a decrease between T0 and T1 for FT (p<0.05). Schirmer 1 values increased significantly for Op in T1. Conclusions. Op was superior to FT in regard to pain, osmolarity, TBUT, and Schirmer 1. Osmoprotectant solutes, such as L-carnitine, could attenuate inflammation and secondary DED. Osmoprotective lubricants can be effectively applied for the prevention of refractive surgery-related dry eye symptoms and signs.http://dx.doi.org/10.1155/2018/4324590 |
| spellingShingle | R. M. Hazarbassanov N. G. T. Queiroz-Hazarbassanov J. N. Barros J. A. P. Gomes Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind Trial Journal of Ophthalmology |
| title | Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind Trial |
| title_full | Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind Trial |
| title_fullStr | Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind Trial |
| title_full_unstemmed | Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind Trial |
| title_short | Topical Osmoprotectant for the Management of Postrefractive Surgery-Induced Dry Eye Symptoms: A Randomised Controlled Double-Blind Trial |
| title_sort | topical osmoprotectant for the management of postrefractive surgery induced dry eye symptoms a randomised controlled double blind trial |
| url | http://dx.doi.org/10.1155/2018/4324590 |
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