Atherogenic Factors and Their Epigenetic Relationships
Hypercholesterolemia, homocysteine, oxidative stress, and hyperglycemia have been recognized as the major risk factors for atherogenesis. Their impact on the physiology and biochemistry of vascular cells has been widely demonstrated for the last century. However, the recent discovery of the role of...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/437809 |
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| _version_ | 1832553737379381248 |
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| author | Ana Z. Fernandez Andrew L. Siebel Assam El-Osta |
| author_facet | Ana Z. Fernandez Andrew L. Siebel Assam El-Osta |
| author_sort | Ana Z. Fernandez |
| collection | DOAJ |
| description | Hypercholesterolemia, homocysteine, oxidative stress, and hyperglycemia have been recognized as the major risk factors for atherogenesis. Their impact on the physiology and biochemistry of vascular cells has been widely demonstrated for the last century. However, the recent discovery of the role of epigenetics in human disease has opened up a new field in the study of atherogenic factors. Thus, epigenetic tags in endothelial, smooth muscle, and immune cells seem to be differentially affected by similar atherogenic stimuli. This paper summarizes some recent works on expression of histone-modifying enzymes and DNA methylation directly linked to the presence of risk factors that could lead to the development or prevention of the atherosclerotic process. |
| format | Article |
| id | doaj-art-3566f6e3325b410fb00984cda44b9b3d |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-3566f6e3325b410fb00984cda44b9b3d2025-02-03T05:53:17ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322010-01-01201010.1155/2010/437809437809Atherogenic Factors and Their Epigenetic RelationshipsAna Z. Fernandez0Andrew L. Siebel1Assam El-Osta2Hemostasia and Vascular Genetics Laboratory, Biophysics and Biochemistry Center, Venezuelan Institute for Scientific Research IVIC, Carretera Panamericana km11, P.O. 26973, Caracas 1020, VenezuelaEpigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, AustraliaEpigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, AustraliaHypercholesterolemia, homocysteine, oxidative stress, and hyperglycemia have been recognized as the major risk factors for atherogenesis. Their impact on the physiology and biochemistry of vascular cells has been widely demonstrated for the last century. However, the recent discovery of the role of epigenetics in human disease has opened up a new field in the study of atherogenic factors. Thus, epigenetic tags in endothelial, smooth muscle, and immune cells seem to be differentially affected by similar atherogenic stimuli. This paper summarizes some recent works on expression of histone-modifying enzymes and DNA methylation directly linked to the presence of risk factors that could lead to the development or prevention of the atherosclerotic process.http://dx.doi.org/10.1155/2010/437809 |
| spellingShingle | Ana Z. Fernandez Andrew L. Siebel Assam El-Osta Atherogenic Factors and Their Epigenetic Relationships International Journal of Vascular Medicine |
| title | Atherogenic Factors and Their Epigenetic Relationships |
| title_full | Atherogenic Factors and Their Epigenetic Relationships |
| title_fullStr | Atherogenic Factors and Their Epigenetic Relationships |
| title_full_unstemmed | Atherogenic Factors and Their Epigenetic Relationships |
| title_short | Atherogenic Factors and Their Epigenetic Relationships |
| title_sort | atherogenic factors and their epigenetic relationships |
| url | http://dx.doi.org/10.1155/2010/437809 |
| work_keys_str_mv | AT anazfernandez atherogenicfactorsandtheirepigeneticrelationships AT andrewlsiebel atherogenicfactorsandtheirepigeneticrelationships AT assamelosta atherogenicfactorsandtheirepigeneticrelationships |