A Review of Psoriasis, a Known Risk Factor for Cardiovascular Disease and Its Impact on Folate and Homocysteine Metabolism

Psoriasis is a chronic inflammatory skin condition with an increased risk of cardiovascular disease. This risk has been attributed to an association with many independent risk factors including obesity, hypertension, smoking, and dyslipidemia. Psoriasis patients also have lower levels of folate and...

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Main Authors: Ian McDonald, Maureen Connolly, Anne-Marie Tobin
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Journal of Nutrition and Metabolism
Online Access:http://dx.doi.org/10.1155/2012/965385
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author Ian McDonald
Maureen Connolly
Anne-Marie Tobin
author_facet Ian McDonald
Maureen Connolly
Anne-Marie Tobin
author_sort Ian McDonald
collection DOAJ
description Psoriasis is a chronic inflammatory skin condition with an increased risk of cardiovascular disease. This risk has been attributed to an association with many independent risk factors including obesity, hypertension, smoking, and dyslipidemia. Psoriasis patients also have lower levels of folate and conversely higher levels of homocysteine, which in itself is a risk factor for cardiovascular disease. It has been postulated that low folate levels in this group may be a direct cause of hyperhomocysteinemia and therefore a treatable risk factor by folate supplementation. This paper looks at the literature published to date on the relationship between psoriasis, homocysteine, and folate levels.
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spelling doaj-art-354c25c3f28b4a36ae899aeb2746dcc12025-02-03T01:32:39ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322012-01-01201210.1155/2012/965385965385A Review of Psoriasis, a Known Risk Factor for Cardiovascular Disease and Its Impact on Folate and Homocysteine MetabolismIan McDonald0Maureen Connolly1Anne-Marie Tobin2Department of Dermatology, The Adelaide and Meath Hospital Incorporating the National Children’s Hospital, Tallaght, Dublin 24, IrelandDepartment of Dermatology, The Adelaide and Meath Hospital Incorporating the National Children’s Hospital, Tallaght, Dublin 24, IrelandDepartment of Dermatology, The Adelaide and Meath Hospital Incorporating the National Children’s Hospital, Tallaght, Dublin 24, IrelandPsoriasis is a chronic inflammatory skin condition with an increased risk of cardiovascular disease. This risk has been attributed to an association with many independent risk factors including obesity, hypertension, smoking, and dyslipidemia. Psoriasis patients also have lower levels of folate and conversely higher levels of homocysteine, which in itself is a risk factor for cardiovascular disease. It has been postulated that low folate levels in this group may be a direct cause of hyperhomocysteinemia and therefore a treatable risk factor by folate supplementation. This paper looks at the literature published to date on the relationship between psoriasis, homocysteine, and folate levels.http://dx.doi.org/10.1155/2012/965385
spellingShingle Ian McDonald
Maureen Connolly
Anne-Marie Tobin
A Review of Psoriasis, a Known Risk Factor for Cardiovascular Disease and Its Impact on Folate and Homocysteine Metabolism
Journal of Nutrition and Metabolism
title A Review of Psoriasis, a Known Risk Factor for Cardiovascular Disease and Its Impact on Folate and Homocysteine Metabolism
title_full A Review of Psoriasis, a Known Risk Factor for Cardiovascular Disease and Its Impact on Folate and Homocysteine Metabolism
title_fullStr A Review of Psoriasis, a Known Risk Factor for Cardiovascular Disease and Its Impact on Folate and Homocysteine Metabolism
title_full_unstemmed A Review of Psoriasis, a Known Risk Factor for Cardiovascular Disease and Its Impact on Folate and Homocysteine Metabolism
title_short A Review of Psoriasis, a Known Risk Factor for Cardiovascular Disease and Its Impact on Folate and Homocysteine Metabolism
title_sort review of psoriasis a known risk factor for cardiovascular disease and its impact on folate and homocysteine metabolism
url http://dx.doi.org/10.1155/2012/965385
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